@font-face {
    font-family: 'SolexOT-Bold';
    font-weight: normal;
    font-style: normal;
    font-display: swap;
    src: url('/etc/designs/code/website-services/us/imfinzi-com/fonts/SolexOT-Bold.eot');
    src: url('/etc/designs/code/website-services/us/imfinzi-com/fonts/SolexOT-Bold.eot?iefix') format('embedded-opentype'), url('/etc/designs/code/website-services/us/imfinzi-com/fonts/SolexOT-Bold.ttf') format('truetype');
  }
  @font-face{
   font-family:'HelveticaNeueLTStd-BdCn';
   src:url(/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-BdCn.eot);
   src:local('?'),url(/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-BdCn.woff) format('woff'),url(/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-BdCn.ttf) format('truetype'),url(/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-BdCn.svg) format('svg');
   font-weight:400;
   font-style:normal;
   font-display: swap;
  }
  @font-face{
   font-family:'HelveticaNeueLTStd-LtCn';
   src:url(/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-LtCn.eot);
   src:local('?'),url(/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-LtCn.woff) format('woff'),url(/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-LtCn.ttf) format('truetype'),url(/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-LtCn.svg) format('svg');
   font-weight:400;
   font-style:normal;
   font-display: swap;
  }
  @font-face {
    font-family: 'HelveticaNeueLTStd-MdCn';
    src: url('/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-MdCn.otf');
   font-display: swap;
  }
  @font-face {
    font-family: 'Roboto-Medium';
    src: url('fonts/Roboto-Medium.eot');
    src: local('?'), url('/etc/designs/code/website-services/us/imfinzi-com/fonts/Roboto-Medium.woff') format('woff'), url('/etc/designs/code/website-services/us/imfinzi-com/fonts/Roboto-Medium.ttf') format('truetype'), url('/etc/designs/code/website-services/us/imfinzi-com/fonts/Roboto-Medium.svg') format('svg');
    font-weight: normal;
    font-style: normal;
   font-display: swap;
  }
  @font-face {
    font-family:"HelveticaNeueLTStd-cn";
    src: url('/fonts/HelveticaNeueLTStd-cn.eot');
    src: local('?'), url('/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-cn.woff') format('woff'), url('/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-cn.ttf') format('truetype'), url('/etc/designs/code/website-services/us/imfinzi-com/fonts/HelveticaNeueLTStd-cn.otf') format('opentype');
    font-weight: normal;
    font-style: normal;
   font-display: swap;
  }

sup.customSup {
    top: -0.4em;
}
.pink-color {
    color: #F615FFDE;
}
ul.hypen-list {
    padding-left: 20px !important;
}

.about-btcs ul.hypen-list {
    padding-left: 47px !important;
}

.hypen-list li:before {
    content: '–' !important;
    left: -20px !important;
}

.about-btcs .arrow-list li.medium-txt{line-height:20px;}

.reference-section a {
    pointer-events: none;
    color: #4A4A4A;
}
#os-mutation-status{margin-top:-30px;}
  .mtop_20 {
   margin-top: 20px;
  }
  .mbottom_20 {
   margin-bottom: 20px;
  }
  .subpage-banner {
   background-image: url(/content/dam/website-services/us/434-imfinzi-com/btc-hcp/btc-subpages/desktop/btc-hcp-ef.jpg);
   background-size: 100% 100%;
   background-repeat: no-repeat;
   height: 115px;
   background-position: center center;
   margin: 0;
  }
  .sunbanner-sec {
       max-width: 722px;
       margin: 0 auto;
       padding-top: 7px;
   }
   .subbanner-flex {
       display: inline-flex;
       width: 100%;
       position: relative;
       align-items: center;
       justify-content: center;
  }  
  .additional-analyses .arrow-list li{line-height:20px;}
  .subpage-banner .banner-subhead-block hr {
   margin: 10px auto;
   width: 50px;
  }
  .subpage-banner p.banner-subhead {
   margin: 4px 5px;
   font-size: 12px;
   line-height: 11px;
   font-family: 'SolexOT-Regular';
   color: #003865;
  }
  .banner-subhead-block hr {
   background: #003865;
  }
  .subpage-banner .banner-subhead-block {
   width: auto;
   align-items: center;
  }
  .banner-liv-img img {
   max-width: 108px;
  }
  p.banner-heading {
   text-align: center;
   letter-spacing: -1.08px;
   line-height: 47px;
   font-size: 54px;
   font-family: 'Solex-Bold';
   color: #9E2A33;
   margin-bottom: 0px;
  }  
  .page-content {
   max-width: 722px;
   margin: 0 auto;
  }
  .sec-header-container.no-barline {
   border-top: transparent;
   margin-top: 2px;
  }
  .sec-header {
   font-size: 15px;
   line-height: 18px;
   font-family: 'RobotoCondensed-Bold';
   background: #003865;
   color: #ffffff;
   padding: 4px 11px 6px 9px;
   border-bottom-left-radius: 8px;
   border-bottom-right-radius: 8px;
  }
  p.eyebrow-txt {
   font-size: 13px;
   font-family: 'RobotoCondensed-Regular';
   line-height: 15px;
   color: #003865;
  }
  .btc-hcp.efficacy .text-enlarge{
          font-family: 'Ubuntu';
      font-weight: 500;
      font-size: 18px;
              }
  .img-space{padding: 20px 10px;}
  .overall-survival-sec p.eyebrow-txt {
   margin: 30px 0 -10px;
  }
  .adverse-reactions-sec .eyebrow-txt {
   margin-bottom:-10px;
  }
  h1.heading {
   color: #9E2A33;
   font-family: 'Ubuntu';
   font-size: 25px;
   letter-spacing: 0.1px;
   line-height: 28px;
  }
  h1.heading sup {
   top: -0.3em;
  }
  .about-btcs #txt-heading{padding-left: 0px;}
  .analysis-sec {
   display: inline-flex;
   width: 100%;
   justify-content: space-around;
   padding: 10px 0 0px;
   margin-bottom:15px;
   position: relative;
  }
  .additional-analyses sup {
      top: -0.4em;
  }
  .analysis-sec hr {
   width: 90%;
   height: 1px;
   margin: 0 20px;
   border-bottom: 1px solid #555555;
   position: absolute;
   bottom: 0;
  }
  .analysis-sec p {
   font-size: 26px;
   line-height: 30px;
   font-family: 'SolexOT-Bold';
   letter-spacing: -0.41px;
  }
  .data-sec-fbig {
   font-size: 20px;
  }
  .progression-free-survival-sec .analysis-left .data-btn-algn {
   top: -2px;
  }
  .data-btn-algn {
   position: relative;
   top: -3px;
  }
  .overall-survival-sec .data-btn-algn {
   /*top: -2.5px;*/
   top: -1.7px;
  }
  .progression-free-survival-sec .analysis-right .data-btn-algn {
   top: -2px;
  }
  .dot-btn-algn {
   top: 2px;
   position: relative;
  }
  .analysis-right p {
   color: #6f7175;
  }
  .analysis-sec p span.sot-reg {
   font-size: 15px;
   line-height: 19px;
   letter-spacing: -0.15px;
  }
  .sot-reg {
   font-family: 'SolexOT-Regular';
  }
  .analysis-right p span.sot-reg {
   letter-spacing: -0.04px;
  }
  .analysis-sec p span.ff-rr {
   font-size: 13px;
   line-height: 18px;
   font-family: 'Roboto-Regular';
   display: block;
  }
  .red-lined {
   display: inline-flex;
   width: 100%;
  }
  .red-lined hr {
   height: 1px;
   background: #AC182E;
   width: 30%;
   margin: 10px auto;
  }
  .hr-footnote p, .os-pfs-head p {
   color: #03315D;
   font-size: 13px;
   line-height: 19px;
   font-family: 'HelveticaNeueLTStd-LtCn';
   text-align: center;
  }
  .overall-survival-sec .hr-footnote p, .progression-free-survival-sec .hr-footnote p {
   padding-bottom: 10px;
   color: #000000;
   font-size: 17px;
   margin: 0 auto;
  }
  .analysis-sec img {
   margin-top: 7px;
  }
  .btc-hcp.efficacy .box-heading b{
      font-weight:900;
              }
  .hr-footnote b, .os-pfs-head p b {
   font-family: 'HelveticaNeueLTStd-BdCn';
  }
  .list-sec {
   margin: 23px auto;
  }
  .bullet-list {    
   padding-left: 20px;
  }
  .hypenated-list , .bullet-list {
   position: relative;
  }
  .hypenated-list li, .bullet-list li {
   list-style-type: none;
  }
  .bullet-list li, .hypenated-list li {
   font-size: 16px;
   line-height: 20px;
   font-family: 'Roboto-Light';
   color: #555555;
   padding-bottom: 5px;
  }
  .bullet-list li::before {
   content: '\2022';
   position: absolute;
   color: #00b09b;
   font-size: 2.5em;
   left: -0.1em;
  }  
  .callout-sec p {
   font-size: 16px;
   line-height: 22px;
   font-family: 'Roboto-Bold';
   margin: 15px 10px;
   color: #003865;
   letter-spacing: -0.32px;
  }
  .callout-sec {
   border: 1px solid #74A9D9;
   border-left: 16px solid #9E2A33;
  }
  .cta-blk-link a {
   color: #4678B0;
   font-size: 16px;
   line-height: 20px;
   font-family: 'Roboto-Light';
   text-decoration: underline;
  }
  .cta-blk-link {
   margin: 25px 0px 20px;
  }
  
  
  /* update 76790 */
  
  .no-cell {
    display: none;
  }

  .extended-text {
    display: block;
    width:300%;
    color: #07729b;
    font-weight: 700;
  }
  .page-content {
   max-width: 722px;
   margin: 0 auto;
  }
  
  
  p.eyebrow {
   margin-top: 30px;
   margin-bottom: -25px;
   color: #003865;
   font-weight: 500;
   font-size: 18px;
  }
  
  p.footnotes {
   margin-bottom: 3px;
   font-size: 14px;
   line-height: 16px;
   color: #4A4A4A;
   font-family: 'Ubuntu';
   text-indent: 0;
   margin-bottom: 8px;
   margin-left: 10px;
  }
  p.footnotes.ml-2 {
    margin-left: 2px;
}
  .footnote-last{
    margin-left: 14px;
    margin-top: 30px;
  }

  p.footnotes.mb0 {
    margin-bottom: 0;
}
.ls-0{
    letter-spacing: 0 !important;
}
.ls1{
    letter-spacing: -0.1px !important;
}
  .dosing p.footnotes {
    margin-bottom: 5px;
}
p.footnotes.ft-n1 {
    text-indent: -5px;
    margin-left: 1px;
}
p.footnotes.ft-n1 sup {
    font-size: 11px !important;
    top: -0.2em !important;
}
.ml-0{
    margin-left: 0 !important;
   }
   p.footnotes.pr-26.ml-0 {
    margin-top: 15px;
}
  .ml-7{
    margin-left: 7px !important;
    display: flex;
  }
  .sd-and-pc p.footnotes {
    margin-bottom: 8px;
    position: relative;
   }
   p.footnotes.lp-01{
    letter-spacing: -0.1px !important;
  }
   p.footnotes.pr-11 {
    padding-right: 21px;
   }
   .lp-3{
    letter-spacing: -0.3px !important;
   }
   .footnote1{
    display: flex;
    margin-left: 5px;
   }
   .mr6{
    margin-left: 6px;
   }
  .box-light-blue {
   color: #7099D3 !important;
  }
  
  .box-image.box-light-blue {
   border: 0.5px solid #7099D3 !important;
	margin: 50px 10px 30px 10px;
  }
  
  
  .box-light-blue:before {
   content: '';
   background: url(/content/dam/website-services/us/434-imfinzi-com/btc-hcp/home/Dark%20Blue%20Arrow.png) no-repeat !important;
   background-size: cover !important;
  }
  .txt-hr-light {
   font-weight: 200;
  }
  
  .vs-line {
   border-top: 1.5px solid #7392aa;
   padding: 5px;
   width: 92%;
  }
  .ef-orr-dor hr.vs-line {
    margin-top: 0px;
    margin-bottom: 0;
  }
  .ef-orr-dor .and-box-wrap{
    margin: 25px auto 10px;
  }
  .data-compare {
   display: flex;
   justify-content: space-evenly;
   width: 80%;
   margin: 0 auto;
   align-items: center;
  }
  
  .data-comp-vs {
   padding: 0 20px;
  }
  .data-comp-bottom.data-grey-txt {
   color: #707070;
  }
  
  p.data-num {
   text-align: center;
  }
  

  ul.patients-characteristics {
    padding: 0;
    margin: 15px 0 30px;
    display: flex;
    justify-content: space-between;
  }
  p.footnotes.mr6.mb35 {
    margin-bottom: 35px;
}
  ul.patients-characteristics li {
    list-style-type: none;
  }
  ul.patients-characteristics li img {
    width: 170px;
    height: 170px;
}  



.position {
    float: left;
    margin: 100px 20px;
  }
  
  .progress-bar {
    position: relative;
    height: 200px;
    width: 200px;
  }
  
  .progress-bar div {
    position: absolute;
    height: 200px;
    width: 200px;
    border-radius: 50%;
  }
  
  .progress-bar div span {
    position: absolute;
    font-family: Arial;
    font-size: 25px;
    line-height: 175px;
    height: 175px;
    width: 175px;
    left: 12.5px;
    top: 12.5px;
    text-align: center;
    border-radius: 50%;
    background-color: white;
  }
  
  .progress-bar .background { background-color: #b3cef6; }
  
  .progress-bar .rotate {
    clip: rect(0 100px 200px 0);
    background-color: #4b86db;
  }
  
  .progress-bar .left {
    clip: rect(0 100px 200px 0);
    opacity: 1;
    background-color: #b3cef6;
  }
  
  .progress-bar .right {
    clip: rect(0 100px 200px 0);
    transform: rotate(180deg);
    opacity: 0;
    background-color: #4b86db;
  }
   @keyframes 
  toggle {  0% {
   opacity: 0;
  }
   100% {
   opacity: 1;
  }
  }





#dosing-box-1 .img-dose{
    margin-right: -28px;
    width: 622px;
}


  .nccn-expanded-text {
   padding-top: 30px;
   padding-right: 10px;
  }
  
  
  .nccn-expanded-text p {
   margin-bottom: 0px;
   font-family: 'Ubuntu', sans-serif;
   color: #003262;
   font-size: 15px;
   line-height: 17px;
   margin-left: 15px;
   font-weight: 400;
  }
  
  .preferred-text {
   font-size: 14px;
   font-family: 'Ubuntu', sans-serif;
   font-weight: 900;
  }
  
  .nccn-category-text {
   font-size: 17px;
   color: #003262;
   font-family: 'Ubuntu', sans-serif;
   padding: 11px;
   line-height: 13px;
   padding-top: 44px;
  }
  
  .category-text {
   font-size: 13px;
   font-weight: 700;
   font-family: 'Ubuntu', sans-serif;
   width: 83px;
   display: inline-block;
  }
  .ncc-bold {
   font-weight: 700;
   font-size: 28px;
   font-family: 'Ubuntu', sans-serif;
  }
  
  .nccn-category-bar {
   display: flex;
   border-top: 1px solid #707070;
   border-bottom: 1px solid #707070;
   background-color: #7099D326;
   position: relative;
   height: auto;
   margin-left: auto;
   margin-right: auto;
   margin-bottom: 50px;
   margin-top: -50px;
   right: 3px;
   padding-left: 10px;
  }
  
  .img-box-padding {
   padding-top: 10px;
   padding-bottom: 10px;
  }
  
  
  .sd-and-pc p.eyebrow {
   margin-top: 0;
   margin-bottom: 0;
  }
  
  .efficacy.btc-hcp .cta-sec p, .callout p {
   color: #AC182E !important
  }
  
  .efficacy.btc-hcp  .arrow-list li {
   line-height:20px;
  }
  .efficacy.btc-hcp .overall-survival-sec .arrow-list li{
                      letter-spacing:-0.16px;
                  }
  .btc-hcp .ef-anchor-sec {
    margin: 0 auto 20px;
    max-width: 722px;
    display: flex;
    flex-direction: row;
  }
  .btc-hcp.efficacy .eff-j1::after{
      top:0px;
                      left:0px;
                  }
.btc-hcp.efficacy .eff-j2::after{
    top:0px;
	left:0px;
    }
  .btc-hcp .ef-anchor-sec > a {
    font-size: 14px;
    line-height: 16px;
    font-weight: 700;
    color: #003865;
    background: #EBF1F8;
    padding: 10px;
    margin-right: 4px;
    height: 50px;
    width: 160px;
    text-align: center;
     display: flex;
      justify-content: center;
      align-items: center;
  }
  
  .btc-hcp .ef-anchor-sec a:after {
    content: '\f078';
    font-family: fontawesome;
    font-weight: 100;
    color: #AC182E;
    position: relative;
    left: 25px;
  }
  
  p.disclaimer-eyebrow {
   color: #555555;
   font-size: 16px;
   font-weight: 600;
   padding-top: 30px;
   padding-bottom: 30px;
   margin: 0px;
  }  
  .sf-treat-modi-table p.disclaimer-eyebrow {
    padding-bottom: 20px;
   }
  .sub-head-topaz {
    font-size: 20px !important;
    font-weight: lighter !important;
    padding-top: 0 !important;
  }
  
  #subhead-safety {
   margin-top: -10px;
   font-weight: 400;
  }
  
  p.disclaimer-eyebrow a {
   color: #555555;
   /*text-decoration-line: underline;*/
  }

  p.disclaimer-eyebrow a:hover {
    text-decoration: none;
  }
  .arrow-list-adverse-reactions li:last-child {
    padding-right: 11px;
   }
  div#dosing-box-1 {
   padding-bottom: 0px !important;
  }
  
  p#dosing-box {
   margin-top: -30px;
  }
  
  p#dosing-box-2 {
    margin-top: -30px;
    padding: 0 6px 0 25px;
}
  
  .prescribing-info {
   font-size: 16px;
   color: #555555;
   font-weight: 600;
  }
  p.mtop_20.mbottom_20.prescribing-info {
    font-size: 18px;
 }
  .prescribing-info a {
   color: #7099D3;
   text-decoration: underline;
  }
  .ds-prep-str-ad ul.arrow-list {
   margin-left: 30px;
   margin-top: 20px;
  }
  .ds-prep-str-ad .page-content-dosing ul.arrow-list {
    margin-left: 0px;
    margin-top: 20px;
    padding-left: 6px;
  }
  .ml-18{
    margin-left: 18px !important;
  }
  .ds-prep-str-ad li {
   line-height: 20px;
  }
  
  ul#no-icon-margin {
    margin-bottom: 30px;
    margin-left: 24px;
    padding-left: 0;
  }
  
  #eyebrow-dosing {
  font-size: 18px !important;
  }
  
  #subhead-dosing {
    font-size: 16px !important;
    line-height: 20px;
    margin-top: -10px !important;
    color: #555555;
  }
  
  .blank-img-box img {
   margin: 0 auto;
  }
  
  
  .two-columns-txt-btc {
   display: flex;
   justify-content: space-between;
  }
  
  .column-txt-btc {
   flex-basis: 48%;
  }
  
  .about-btcs.btc-hcp .medium-txt {
   font-weight: 500;
  }
  
  .about-btcs.btc-hcp  ul.light-txt {
   padding-left: 80px;
  }
  .about-btcs.btc-hcp  .light-txt li {
   line-height: 10px;
  }
  
  .about-btcs.btc-hcp  .light-txt li::before {
   top: -8px;
   left: -15px;
   content: '_';
  }
  .about-btcs.btc-hcp  .hypen-list.light-txt li::before {
   top: -2px;
  }
  .about-btcs.btc-hcp .section-heading span {
   background: #7B7B7B;
  }
  
  .about-btcs.btc-hcp .section-heading {
   border-top: 1px solid #7B7B7B;
  }
  
  span.add-ana-txt-blue {
   color: #003466;
   font-weight: 500;
  }
  
  
  span.add-ana-txt-red {
   color: #AC182E;
   font-weight: 500;
  }
  
  span.add-ana-txt-gray {
   color: #555555;
   font-weight: 700;
  }
  



  .additional-analyses h2.sub-head-topaz {
   margin-top: 0px;
   padding-top: 0px;
   margin-bottom: 0px;
   padding-bottom: 0px;
  }
  
  .additional-analyses .ef-anchor-sec a:after {
   content: '\f078';
   font-family: fontawesome;
   font-weight: 100;
   color: #AC182E;
   position: relative;
   left: 3px;
   top:0px;
  }
  
  
  .btc-hcp .ef-anchor-sec > a {
   font-size: 13px;
  }
  
  a.add-ana-j3:after {
    position: relative;
    top: 10px;
  }
  
  .add-ana-j3 {
   padding-top: 15px !important;
  }
  
  .eff-j1::after {
  
   top:10px;
  }
  
  .eff-j2::after {
  
   top:-6px;
  }
  
  span.big-txt {
   font-size: 20px;
  }
  
  #txt-nowrap-2 {
   white-space: nowrap;
  }
  
  h2#\#subhead-safety {
    margin-top: 0px !important;
  }
  
  .additional-analyses .mtop-1rem {
    margin-top: -1rem !important;
  }
  


  .ds-btc td:first-child, th:first-child {
    text-align: left;
    border-left: none;
    border-right: 1px solid #bcbec0;
    padding-left: 1rem;
    color: #333;
}


.ds-btc th:nth-child(2) {
    border-right: 1px solid #bcbec0;
}

.ds-btc th:nth-child(2), .ds-btc th:nth-child(3) {
    text-align: left;
    padding-left: 1rem;
}

.ds-btc th:nth-child(2), .ds-btc th:nth-child(3) {
    text-align: center;
    padding-left: 1rem;
    /* border: none; */
}
.border-r-b-none th{
    border-right: none !important;
    /* border-bottom: none; */
    /*padding-bottom: 3px;*/
    padding-left: 5px;
    /* font-family: 'Karbon-Bold'; */
    font-family: 'Karbon-Medium'
}
.bb-none th{
    border-bottom: none;
}
.br-none {
    border-right: none !important;
}
td.span-cell.tb-sticky.br-none {
    background: rgb(7 114 155 / 20%);
}
.dosage-modifi td.span-cell.tb-sticky.br-none {
    background: #cde3eb;
}
.border-r-b-none th:nth-child(2), .border-r-b-none th:nth-child(3) {
    color: #00618b;
    text-align: center;
    /* font-family: 'Karbon-Bold'; */
    font-family: 'Karbon-Medium';
    padding-right: 10px;
}
.ds-btc .span-row, .ds-btc .span-row td {
    /* background: #CCDAF1; */
}

.tbl_pati-char th, .tbl_pati-char td {
    font-size: 14px;
}
.tbl_pati-char .span-row td:nth-child(2) {
    background: #ecf4f7;
    color: #07729b;
    font-family: 'Karbon-Medium';
    border-color: #c7cbcda1;
}
.tbl_pati-char .border-r-b-none th {
    /* font-family: 'Karbon-Bold'; */
    font-family: 'Karbon-Medium';
    border-color: #c7cbcda1;
    padding-top: 0;
}
.tbl_pati-char .border-r-b-none th:last-child {
    color: #808285;
}
.tbl_pati-char td.span-cell.tb-sticky {
    /* padding-left: 0; */
    /* font-family: 'Karbon-Bold'; */
    font-family: 'Karbon-Medium';
    padding: 9px 0 !important;
}
.tbl_pati-char .span-row td:nth-child(1) {
    font-family: 'Karbon-Medium';
    border-color: #c7cbcda1;
    padding: 9px 10px;
}   
.pl-20{
    padding-left: 20px !important;
}
.tbl_pati-char .span-row td:nth-child(3) {
    font-size: 13px;
    font-family: 'Karbon-Medium';
    border-color: #c7cbcda1;
}
.key-table1{
    padding-bottom: 25px !important;
}
.laboratory-abnormalities td:nth-child(1) {
    padding-right: 0 !important;
    /* width: 240px; */
    max-width: 100%;
    width: 220px;
    font-family: 'Karbon-Medium';
    color: #33363a;
    padding-left: 15px !important;
}

.laboratory-abnormalities sup {
    top: 0px;
    font-size: 16px;
}
.laboratory-abnormalities .sup9{
    font-size: 9px;
    top: -4px;
    left: 1px;
}
.laboratory-abnormalities td.span-cell.tb-sticky {
    padding-left: 5px !important;
}
/* .ds-btc td:nth-child(1), .ds-btc td:nth-child(2), .ds-btc .span-row td:nth-child(2), .ds-btc td:nth-child(3), .ds-btc .span-row td:nth-child(3){
    background: #ecf4f7;
} */
/* .laboratory-abnormalities td:nth-child(1), */

.laboratory-abnormalities td:nth-child(2), .laboratory-abnormalities .span-row td:nth-child(2), .laboratory-abnormalities td:nth-child(3), .laboratory-abnormalities .span-row td:nth-child(3) {
    background: #ecf4f7;
    font-weight: 600;
    color: #00618b;
    font-family: 'Karbon-Medium' !important;
    /* font-family: 'Karbon' !important; */
}
.ds-btc th {
    /* color: #07729b; */
}
.laboratory-abnormalities{

}
.laboratory-abnormalities span.extended-text {
    color: #00618b;
}
.color-blue{
    color: #00618b !important;
}
.color-grey{
    color: #6d6f72 !important;
}
.clr-blue{
  color:#07729b !important;
}
.clr-blk{
  color:#4d4d4f !important;
}
.clr-gry{
    color:#808285 !important;
    font-family: 'Karbon-Medium';
  }
  .laboratory-abnormalities .laboratory-abnormalities-mob td {
    /* font-size: 12px !important;
    font-family: 'Karbon'; */
    font-size: 13px !important;
    font-family: 'Karbon-Medium';
}
.ds-btc td.blue-row {
    background: #E8F1F7;
}

.ds-btc td, .ds-treat th {
    white-space: normal;
    text-align: center;
    padding: 7px 10px;
    line-height: 18px;
}
.ds-btc .laboratory-abnormalities td:nth-child(5) {
    color: #4a4a4a;
}

.ds-btc table tr:last-child td {
    border-bottom: 1px solid #bcbec0;
}

.tb-txt-indent {
    text-indent: 10px;
    display: block;
}

td.red-f-cell, th.red-f-cell {
    color:#AC182E;
}

.dosage-modifi .border-r-b-none th {
    padding-bottom: 15px;
    font-size: 16px;
    color: #07729b;
    line-height: 19px;
    padding-top: 0;
}

.dosage-modifi td.tb-sticky {
    color: #4d4d4f;
    /* font-family: 'Karbon-Bold'; */
    /* font-family: 'Karbon'; */
    font-family: 'Karbon-Medium'
}
.dosage-modifi td.span-cell.tb-sticky.br-none span.extended-text {
    /* font-family: 'Karbon-Bold'; */
    font-family: 'Karbon-Medium'
}
.dosage-modifi td {
    font-family: 'Karbon-Medium';
    color: #808285;
    font-size: 16px;
    line-height: 16px;
    padding: 10px 10px;
    letter-spacing: -0.3px;
}
.dosage-modifi td:nth-child(2) {
    padding: 10px 5px;
}
.wp-nw{
    white-space: nowrap !important;
}
.dosage-modifi td.tb-sticky {
    width: 225px;
    max-width: 225px;
    white-space: nowrap;
    line-height: 15px;
    padding: 0 20px 0 40px;
}
.dosage-modifi td.span-cell.tb-sticky.br-none {
    text-align: left;
    padding: 9.5px 10px;
}
.ds-btc.table-block.desktop-only.dosage-modifi {
    max-width: 625px;
}
td.bg-blank {
    background: #cde3eb;
    border-right: none;
}
.box-image.bx-img-dos {
    padding: 20px 0px 10px 20px !important;
}
.hr-scroll-txt p {
    font-weight: 700;
    font-size: 16px;
    line-height: 20px;
    letter-spacing: 0.03px;
    position: relative;
    color: #4a4a4a;
}

.eff-table-pat-ch th:first-child {
    padding: 0px;
    width:250px;
}


/* update 76790 end */
  
  
  
  .data-red-txt, .data-red-txt p {
   color: #AC182E;
   text-align: center;
  }
  
  .ef-anchor-sec a {
   font-size: 14px;
   line-height: 16px;
   font-weight: 700;
   color: #003865;
   background: #EBF1F8;
   padding: 13.5px 19px;
  }
  .ef-anchor-sec a:after {
   content: '\f078';
   font-family: fontawesome;
   padding-left: 5px;
   font-weight: 100;
   color: #AC182E;
  }
  .ef-anchor-sec a.anchor-up:after {
   content: '\f077';
  }
  .ef-anchor-sec a:hover {
   color: #ffffff;
   background: #003262;
   text-decoration: none;
  }
  .ef-anchor-sec a:hover:after {
   color: #ffffff;
  }
  .percentage-number {
   font-size: 32px;
   font-weight: 900;
  }
  .reduction-text {
   font-family: 'Ubuntu', sans-serif;
   font-size: 18px;
   line-height: 20px;
   color: #07729b;
   text-align: center;
   margin-top: 28px;
   font-weight: 900;
   margin-bottom: 30px;
   letter-spacing: -0.54px;
  }
  .blu-txt {
    color: #07729b;
    font-weight: normal;
  }
  .reduction-text.customMargin {
   margin-bottom: 6px;
  }
  
  span.gray-txt {
   color: #707070;
    font-weight: normal;
  }

  .hr-text {
   color: #AC182E;
   font-family: 'Ubuntu', sans-serif;
   line-height: 14px;
   text-align: center;
   font-size: 12px;
   margin-bottom: 6px;
   margin-top: 3px;
   font-weight: 500;
  }
  

.callout-wrap {
    display: flex;
    align-items: center;
    justify-content: center;
    /* max-width: 594px; */
    max-width: 720px;
    margin: 50px auto 42px;
    padding-right: 20px;
}
.callout-wrap img {
    width: 95px;
    height: 95px;
    margin-right: 30px;
}
p.callout-head {
    font-weight: 500;
    font-size: 21px;
    line-height: 20px;
    letter-spacing: 0.21px;
    color: #003262;
    margin-bottom: 2px;
}
.callout-copy p span.sub-text {
    font-size: 18px;
    line-height: 18px;
    letter-spacing: 0.18px;
}
.callout-copy p {
    font-family: "Ubuntu", sans-serif;
    margin-bottom: 0;
    /* padding-right: 12px; */
}
.pr-6{
    padding-right: 6px;
}
p.callout-txt {
    font-size: 16px;
    line-height: 20px;
    font-weight: 300;
    color: #555555;
    margin-top: 15px;
}
.fw-bold {
    font-weight: 700;
}
ul.light-blue-list {
    list-style-type: none;
    padding-left: 0px;
    padding-right: 26px;
    margin-bottom: 34px;
}
ul.first--list li:first-child {
    padding-bottom: 17px;
}
.pr-20{
    padding-right: 20px !important;
}
ul.light-blue-list li {
    font-size: 16px;
    line-height: 20px;
    font-family: "Ubuntu", sans-serif;
    font-weight: 300;
    position: relative;
    padding-left: 29px;
    color: #555555;
}
.pr-10 {
    padding-right: 10px;
}
ul.light-blue-list > li:before {
    content: "";
    width: 23px;
    height: 14px;
    display: inline-block;
    position: absolute;
    left: 0;
    top: 4px;
    background: url(/content/dam/website-services/us/434-imfinzi-com/dec-hcp/dec-subpages/desktop/light-blue-arrow.png) no-repeat;
    background-size: cover;
}


.arrow-callout {
    max-width: 698px;
    margin: 28px 0 45px auto;
    padding: 18px 0 18px 51px;
    border: 0.5px solid #7392aa;
    position: relative;
}
.arrow-callout:before {
    content: "";
    width: 60px;
    height: 36px;
    display: inline-block;
    position: absolute;
    top: 13px;
    left: -23px;
    background: url(/content/dam/website-services/us/434-imfinzi-com/dec-hcp/dec-subpages/desktop/callout-arrow-blue.svg) no-repeat;
    background-size: contain;
}
.arrow-callout p {
    color: #AC182E;
    font-size: 21px;
    line-height: 25px;
    font-family: "Ubuntu", sans-serif;
    font-weight: 500;
    margin-bottom: 0;
}
.arrow-callout2 {
    margin: 18px 0 27px auto;
}
.arrow-callout3 {
    margin: 34px 0 30px auto;
}
.pr10{
    padding-right: 10px;
}
.learn-how{
    display: flex;
    justify-content: space-evenly;
    padding: 13px 24px;
    align-items: center;
    border: 1px solid #7593ac;
    margin: 30px 0 40px;
}
.learn-how img.img-learn {
    width: 141px;
}
.learn-how a {
    color: #ac182e;
    font-size: 21px;
    line-height: 25px;
    /*text-decoration: underline;*/
    font-weight: 500;
    position: relative;
    letter-spacing: 0.4px;
}
.learn-how a:hover {
    text-decoration: none;
}
.learn-how a::after {
    content: '\f054';
    font-family: fontawesome;
    font-weight: 100;
    font-size: 16px;
    position: absolute;
    -webkit-text-stroke: 0.5px #ffffff;
    color: #AC182E;
    padding-left: 46px;
    padding-top: 3px;
}
.learn-how sup {
 /* text-decoration: underline; */
}
.safety .patients-permanently-discontinued {
    background: #07729b;
    padding: 10px 17px;
    margin-bottom: 50px;
}
.safety .patients-permanently-discontinued h3,
.safety .patients-permanently-discontinued h2 {
    font-size: 21px;
    line-height: 25px;
    color: #ffffff;
    margin: 0 0 8px;
    padding: 0;
}
.safety .patients-permanently-discontinued h4 {
    font-size: 16px;
    line-height: 18px;
    color: #ffffff;
    margin: 0;
    padding: 0;
    position: relative;
    padding-left: 35px;
    font-weight: 400;
}
.safety .patients-permanently-discontinued h4:before {
    content: '';
    background: url(/content/dam/website-services/us/434-imfinzi-com/dec-hcp/dec-subpages/desktop/white-arrow.png) no-repeat;
    background-size: 100%;
    position: absolute;
    width: 30px;
    height: 17px;
    top: 0;
    left: 0;

}


  /* 
  
  .nccn-blck {
   border-top: 1px solid #74A9D9;
   border-bottom: 1px solid #74A9D9;
   display: inline-flex;
   padding: 16px 0px 10px;
   margin-bottom: 20px;
   align-items: center;
  }
  .nccn-blck p {
   color: #003466;
   font-size: 16px;
   line-height: 19px;
   font-family: 'RobotoCondensed-Regular';
   letter-spacing: -0.32px;
  }
  p.nccn-txt {
   font-size: 50px;
   font-family: 'RobotoCondensed-Bold';
   margin-right: 10px;
  }
  span.nccn-subtxt {
   font-size: 14px;
   display: block;
   margin-top: 10px;
   letter-spacing: 0.3px;
  } */
  
  .table-heading p, .rd-compare-sec .table-heading p {
   color: #0F3763;
   font-size: 17px;
   line-height: 19px;
   font-family: 'RobotoCondensed-Bold';
   margin:0 5px;
   text-align: center;
  }
  .table-heading hr {
   width: 24%;
  }
  .ef-stud-bullet-sec-1 p.bullet-heading {
   margin-bottom: 27px;
  }
  /* p.footnotes {
   margin-bottom: 3px;
   font-size: 14px;
   line-height: 16px;
   color: #4A4A4A;
   font-family: 'Ubuntu';
  } */
  .ef-OS-Forrest-Plot-Chart {
   margin: 25px auto 50px;
  }
  .ef-OS-Forrest-Plot-Chart .table-heading {
   margin-bottom: 20px;
  }    
  .subhead {
   color: #003865;
   font-size: 16px;
   line-height: 20px;
   font-family: 'Roboto-Bold';            
  }
  .main-txt {
   color: #6f7175;
   font-family: 'ubuntu';
   font-size: 18px;
   text-align: center;
   margin: 20px auto 10px;
  }
  .sec-header-container {
   border-top: 1px solid #003865;
   padding-top: 3px;
  }
  .progression-free-survival-sec .sec-header-container {
   margin: 25px 0;
  }
  .progression-free-survival-sec .table-heading hr {
   width: 21%;
  }
  .pfs-Chart {
   margin: 0px auto 15px;
  }
  .progression-free-survival-sec .callout-sec {
   margin-bottom: 25px;
  }
  .ef-dor-Chart {
   margin: 25px auto 35px;
  }
  .ef-dor-Chart .table-heading {
   margin-bottom: 15px;
  }
  .ef-orr-Chart {
   margin-right: 50px;
  }
  .ef-orr-Chart .table-heading hr {
   width: 15%;
  }
  .ef-dor-Chart .table-heading hr {
   width: 18%;
  }
  .ef-mtr-Chart .table-heading hr {
   width: 23%;
  }
  .ef-key-patient-char-table .table-heading hr {
   width: 31%;
  }
  .ef-orr-mtr-img-sec {
   display: inline-flex;
  }
  .ef-mtr-Chart img {
   margin: 0px auto 10px;
   width: 100%;
  }
  .ef-orr-mtr-img-sec .table-heading p {
   text-align: center;
  }
  .ef-orr-mtr-img-sec > div {
   width: 50%;
  }
  .ef-mtr-Chart .footnotes {
   margin-top: 26px;
  }
  .ef-bullet-img-blck, .ef-bullet-bullet-blck {
   display: inline-flex;
   width: 100%;
  }
  .ef-stud-eligibility-section {
   border-top: 1px solid #74A9D9;
   border-bottom: 1px solid #74A9D9;
   padding: 20px 0px 30px;
   margin: 20px auto;
  }
  .ef-bullet-img-blck {
   padding-bottom: 30px;
   margin-bottom: 26px;
   align-items: center;
  }
  p.bullet-heading {
   color: #0F3763;
   line-height: 29px;
   font-size: 21px;
   font-family: 'RobotoCondensed-Bold';
  }
  .sd-and-pc .sec-header-container {
   margin: 57px auto 30px;
  }
  .ef-stud-bullet-sec-1, .ef-stud-bullet-sec-2 {
   width: 40%;
  }
  /* .sd-and-pc .page-content :nth-child(11) {
   margin: 55px auto 20px;
  } */
  .ef-key-patient-char-table .red-lined.table-heading {
   margin: 30px auto;
  }
  .sd-and-pc .callout-sec {
   margin: 35px auto 0px;
  }
  .adverse-reactions-sec .table-heading {
   margin: 25px auto 30px;
  }
  .adverse-reactions-sec .table-heading hr {
   width: 20%;
  }
  .OS-KM-Curve-Chart.chart-img img.desktop-only {
   margin-bottom: 15px;
  }
  /*table design*/
  table {
   border-collapse: collapse;
   border-spacing: 0;
   width: 100%;
   margin: 0 auto;
  }
  .customTable th, .customTable td {
   padding: 1.5px 8px;
   text-align: center;
   color: #ffffff;
  }
  .customTable th {
   font-family: 'HelveticaNeueLTStd-BdCn';
   letter-spacing: 0.03px;
   font-size: 16px;
   line-height: 19px;
   padding: 3px 8px;
  }
  .bg-red-cell {
   background: #A2192A;
  }
  .bg-grey-cell {
   background: #85868A;
  }
  .bg-blue-cell {
   background: #03315D;
  }
  th.bg-white-cell {
   background: #ffffff;
   color: #03315D;
  }
  .customTable td:nth-child(1) {
   text-align: left;
   border-left:none;
  }
  .customTable td.chart-body, .customTable td.span4 {
   border-left: none;
  }
  .customTable td {
   border: 1px solid #7099D3;
   border-right: none;
   color: #2B2E34;
   font-size: 16px;
   line-height: 22px;
   font-family:'HelveticaNeueLTStd-LtCn';
  }
  td.chart-body, td.chart-body-copy {
   letter-spacing: -0.1px;
  }
  td.span4 {
   background-color: #E8F1F7;
   border-top: 1px solid #7099D3;
   color: #03315D;
   font-size: 16px;
   line-height: 22px;
   font-family:'HelveticaNeueLTStd-BdCn';
  }
  td.chart-body.chart-indent {
   text-indent: 10px;
  }
  .sf-treat-modi-table .desktop-only td.chart-body-copy {
   text-align: left;
  }
  .sf-treat-modi-table .mobile-only td {
   text-align: center;
  }
  .sf-treat-modi-table .table-section {
   margin: 30px 0 10px;
  }
  .sf-treat-modi-table .customTable.desktop-only td.chart-body-copy {
   border-left: 0.5px solid #7099D3;
  }
  .sf-treat-modi-table .chart-body b {
   font-family: 'HelveticaNeueLTStd-BdCn';
  }
  /*Switch page section design*/
  .switch-section {
   margin: 40px auto 10px;
   display: inline-flex;
   width: 100%;
   justify-content: space-between;
   position: relative;
  }
  .switch-section a {
   color: #173A64;
   font-family: 'Ubuntu';
   font-size: 20px;
   line-height: 19px;
   padding: 30px 50px;
   text-transform: uppercase;
  }
  .switch-section a:before {
   background: url(/content/dam/website-services/us/434-imfinzi-com/btc-hcp/btc-subpages/desktop/page-switch-icon.png) no-repeat;
   content: '';
   width: 32px;
   height: 32px;
   position: absolute;
   left: 0;
   top: 22px;
  }
  .switch-section a.switch-after:before {
   right: 0;
   left: auto;
   transform: rotate(180deg);
  }
  .customTable th.chart-col-heading {
   border: 1px solid #7099D3;
   border-right: none;
   color: #03315D;
   font-size: 16px;
   line-height: 19px;
   font-family: 'RobotoCondensed-Bold';
  }
  .efficacy h1.heading {
   margin-bottom: 20px;
  }
  .sf-ar-table th.bg-red-cell, .sf-ar-table th.bg-grey-cell,
  .sf-lab-abnormalities-table th.bg-red-cell, .sf-lab-abnormalities-table th.bg-grey-cell{
   padding: 10px 8px;
  }
  .sf-ar-table td.chart-body-copy {
   width: 120px;
  }
  .discontinuation-rates-sec .sec-header-container {
   margin: 50px auto 25px;
  }
  .dis-rate-section {
   border: 1px solid #7099D3;
   padding: 10px 30px 10px 30px;
  } 
  .dis-rate-section p {
   text-align: center;
  }
  .dis-rate-comp {
   display: inline-flex;
   width: 100%;
   justify-content: center;
   font-family: 'SolexOT-Bold';
   margin: 5px auto;
  } 
  .ef-immune-mediated-ar h1 {
   margin: 31px auto 20px;
  }
  .dis-rate-comp p{
   font-size: 35px;
   line-height: 43px;
   letter-spacing: -0.59px;
   padding-left: 40px;
   color: #6F7175;
  }
  .dis-rate-comp .small-font {
   font-size: 39px;
  }
  .dis-rate-comp .red-txt .data-btn-algn {
   top: -3px;
   font-size: 35px;
  }
  .dis-rate-comp p.red-txt{
   border-right: 2px solid #7099D3;
   padding-right: 40px;
   padding-left: 0px;
   color: #A2192A;
  }
  .dis-rate-comp p span.sot-reg {
   font-size: 16px;
   line-height: 20px;
   letter-spacing: -0.05px;
  }
  p.red-txt span.sot-reg {
   color: #BA2527;
  }
  .red-txt .ff-rr {
   color: #9E2A33;
  }
  .analysis-right .ff-rr {
   color: #555555;
  }
  .ef-immune-mediated-ar .sec-header-container {
   margin: 60px auto 30px;
  }
  .hypenated-list li:before {
   content: '—';
   color: #1EAE9A;
   font-size: 16px;
   line-height: 12px;
   font-family: 'Roboto-Bold';
   left: 20px;
   position: absolute;
   top: 5px;
  }
  .sf-lab-ab .sec-header-container {
   margin: 30px auto;
  }
  .sf-lab-abnormalities-table .table-heading {
   margin: 10px auto 30px;
  }
  .sf-lab-abnormalities-table .table-heading hr {
   width: 41%;
   margin: 20px auto;
  }
  .sf-lab-abnormalities-table .table-heading p {
   text-align: center;
  }
  th.sub-th {
   color: #2B2E34;
   font-size: 16px;
   font-family: 'HelveticaNeueLTStd-MdCn';
   line-height: 22px;
   border-left: 1px solid #7099D3;
  }
  .sf-ar-table {
   margin-bottom: 25px;
  }
  .sf-lab-abnormalities-table .customTable {
   margin-bottom:20px;
  }
  .sf-lab-ab ul.bullet-list {
   margin: 20px auto 0;
  }
  .rd-compare-sec {
   display: inline-flex;
   width: 100%;
   margin: 15px auto 0;
  } 
  .rd-start-with img, .rd-continue img {
   display: block;
   margin: 0 auto;
  }
  .rd-start-with, .rd-continue {
   width: 50%;
  }
  .rd-compare-sec p {
   text-align: center;
   line-height: 16px;
   font-size: 16px;
   font-family: 'Roboto-Light';
   color: #555555;
  }
  .rd-start-with img {
   margin-top: -18px;
  }
  p.rd-comp-footnote {
   font-size: 14px;
   line-height: 15px;
   font-family: 'RobotoCondensed-Light';
   color: #555555;
   margin-top: 10px;
  }
  .rd-start-with p.rd-comp-footnote {
   float: left;
   padding-right: 30px;
   margin-top: 0;
  }
  p.rd-compare-head {
   font-size: 22px;
   line-height: 24px;
   font-family: 'RobotoCondensed-bold';
   color: #000000;
   margin-top: 23px;
  }
  .recommended-dosage .callout-sec {
   margin: 38px auto 36px;
  }
  .sf-treat-modification-section {
   display: inline-flex;
  }
  .sf-treat-modification-section div {
   width: 50%;
  }
  .with-imfi-blck {
   margin-right: 15px;
  }
  .sf-treat-modification-section p, .sf-treat-modification-section ul.bullet-list  {
   border-top: 1px solid #4678B0;
   border-bottom: 1px solid #4678B0;
   margin-bottom: 0;
   font-size: 16px;
   color: #173A64;
   padding: 5px 0px 5px 10px;
   font-family: 'RobotoCondensed-Bold';
  }
  .sf-treat-modification-section p span {
   color: #555555;
   font-family: 'Roboto-Regular';
   padding: 0;
  }
  .t-diff span.red-txt {
   color: #A2192A;
   font-family: 'RobotoCondensed-Bold';
  }
  span.t-diff {
   display: inline-flex;
   align-items: center;
   width: 100%;
  }
  span.t-diff span {
   margin: 0px 5px;
   font-size: 16px;
   line-height: 19px;
   text-align: center;
  }
  p.treat-last {
   color: #ffffff;
   background: #4678B0;
   text-align: center;
   padding: 15px;
  }
  p.treat-head {
   background: #D3E3EF;
  }
  .psa-sec {
   display: inline-flex;
   align-items: center;
   width: 100%;
   margin-bottom: 10px;
  }
  .psa-sec.top-algn-sec img {
   margin-top: -10px;;
  }
  /* .storage-blck p {
   font-size: 16px;
   line-height: 20px;
   font-family: 'Roboto-Light';
   color: #555555;
  } */
  .psa-sec img {
   margin-right: 15px;
   max-width: 57px;
  }
  .red-lined.table-heading.treat-head p {
   color: #A2192A;
   border: none;
   font-family: 'RobotoCondensed-Bold';
   font-size: 16px;
   line-height: 19px;
  }
  .red-lined.table-heading.treat-head hr {
   background: #4678B0;
   height: 1px;
  }
  .red-lined.table-heading.treat-head {
   width: 100%;
   align-items: center;
  }
  .discon-imfi-blck .red-lined.table-heading.treat-head hr {
   width: 11%;
  }
  .recommended-dosage p.eyebrow-txt {
   margin-top: 30px;
  }
  .recommended-dosage p.subhead {
   margin-top: 25px;
  }
  .treatment-modifications-sec p.subhead {
   margin: 20px auto 22px;
   color: #555555;
  }
  .sf-ebook-blck {
   border: 1px solid #7099D3;
   max-width: 450px;
   width: 100%;
   margin: 90px auto 30px;
  }
  .sf-ebook-blck p {
   color: #9E2A33;
   font-size: 20px;
   font-family: 'Roboto-Medium';
   line-height: 24px;
   max-width: 378px;
   margin: 0 auto 50px;
   text-align: center;
  }
  .sf-ebook-blck p a {
   color: #4678B0;
   text-decoration: underline;
  }
  .sf-ebook-blck img {
   margin: -13% auto 30px;
   display: block;
   width: 100%;
   max-width: 81px;
  }
  .discon-imfi-blck ul.bullet-list li {
   margin-bottom: 15px;
  }
  .psa-sec p {
   font-size: 16px;
   line-height: 19px;
   color: #555555;
   font-family: 'Roboto-Light';
  }
  .sf-treat-modification-section .bullet-list li::before {
   font-size: 1.5em;
  }
  .ds-prep-str-ad p.sec-header-container {
   margin: 60px auto 25px;
  }
  .subhead a {
   text-decoration: underline;
  }
  .ds-prep-str-ad .footnotes {
   margin-top: 20px;
  }
  a.subhead-link {
    color: #003262;
    text-decoration: none;
  }
  .dosing a.subhead-link:hover {
   text-decoration: none;
  }
  .ds-prep-str-ad h1.heading {
   margin: 20px auto;
  }
  .dos-blck img {
   margin-right: 10px;
  }
  .ef-orr-dor .sec-header-container {
   margin-top: 50px;
  }
  /* .sf-treat-modi-table th {
   border-right: 1px solid #ffffff;
  } */
  .sf-treat-modi-table th:last-child {
   border-right: none;
  }
  .sf-treat-modi-table .desktop-only tr td.chart-body-copy:last-child {
   text-align: center;
  }
  .sf-treat-modi-table td.span4 {
   background: #ffffff;
  }
  .sf-treat-modi-table tr.blue-row {
   background: #E8F1F7;
  }
  .sf-treat-modi-table .desktop-only td.chart-body {
   white-space: nowrap;
  }
  hr.os-data-hr {
   width: 29%;
  } 
  .btc-table-section {
   margin: 0 auto;
  }
  .sd-and-pc .btc-table-section {
   margin-bottom: 10px;
  }
  .ef-orr-Chart img {
   margin: 0 auto;
   display: block;
  }
  /*.overall-survival-sec .nccn-txt img {
   width: 100%;
  }*/
  
  body.efficacy.btc-hcp .reference-section {
      font-weight: 400;
      padding-right: 13px;
  }
  
  .break-work {
      word-break: break-all;
  }
  
  /*body.efficacy.btc-hcp  h2#eff-head-1 + .box-image {
      margin-bottom: 50px;
  }*/
  
  .discontinuation-rates-sec .img-box-padding + img {
      margin: -15px auto 5px!important;
  }
  
  body.safety.btc-hcp h2#\#subhead-safety sup {
      top: -0.45em;
      font-size: 15px;
  }
  
  body.dosing.btc-hcp sup {
      font-size: 65%;
      top: -0.4em;
  }
  body.dosing.btc-hcp .dosage-modifi sup {
    font-size: 100%;
    top: -0.14em;
  }
  .sup-pd{
    font-size: 75% !important;
    top: -0.34em !important;
  }
  body.dosing.btc-hcp .dosage-modifi sup.sup-bar {
    font-size: 75%;
  }
  .single-footnote sup {
    top: -.5em !important;
 }
 .ft-note p.footnotes {
    margin-left: 0;
 }
 .ft-note .single-footnote sup {
    left: -1px;
 }
 .ft-note p.footnotes:nth-child(8), .ft-note p.footnotes:nth-child(9), .ft-note p.footnotes:nth-child(8), .ft-note p.footnotes:nth-child(10) {
    margin-left: -3px;
}
  .font73{
    font-size:74% !important;
  }
  body.dosing.btc-hcp p.footnotes.fn-2 {
      text-indent: 2px;
      margin-top: 16px;
  }
  p.footnotes.ml-7.mb0.ls-0 {
    text-indent: 0;
  }
  p.footnotes.ml-7.mb0.ls-0 .single-footnote sup {
    left: -6px;
  }
  body.safety.btc-hcp.desktop p.footnotes.ml-7.mb0.ls-0 {
    margin-left: -4px !important;
  }
  body.safety.btc-hcp.desktop p.footnotes.ml-7.mb0.ls-0 .single-footnote sup {
    left: 0px;
 }
  @media screen and (min-width: 768px) and (max-width: 991px){
   .sunbanner-sec {
       padding-top: 20px;
   }
  }
  @media screen and (min-width: 992px) {
   /*.section-linking {
       scroll-margin-top: 127px;
   }*/

   .about-btcs #column-txt-heading{font-size:16px; line-height:24px;}
   .sunbanner-sec {
       padding-top: 21px;
   }    
   .banner-liv-img {
       position: absolute;
       left: 0;
   }
  
   .ef-bullet-img-blck img {
       margin-top: 60px;
   }
   .ef-bullet-img-blck {
       border-bottom: 1px solid #9C2B36;
   }
   .adverse-reactions-sec h1.heading {
       margin-bottom: 20px;
   }
   .ef-immune-mediated-ar p.subhead {
       margin-bottom: 30px;
   }
   .treatment-modifications-sec p.sec-header-container {
       margin: 68px auto 25px;
   }
   /* .recommended-dosage h1.heading {
       margin: 10px auto 20px;
   } */
  
  
   .recommended-dosage h1.heading {
     margin: 10px auto 20px;
     font-size: 24px;
     color: #AC182E;
     font-weight: 500;
     font-family: 'Ubuntu';
  }
  
   .dis-rate-comp p span.sot-reg {
       position: relative;
       bottom: 6px;
   }
   .analysis-sec p {
       font-size: 23px;
   }
   .data-sec-fbig {
       font-size: 20px;
   }
   .ef-orr-mtr-img-sec img {
       margin-top: 25px;
   }
  
      .about-btcs .about-btcs-sec .page-content > h2:nth-child(1) {
          width: 101%;
      }
  
      .efficacy.btc-hcp h2#eff-head-1 + .box-image .reduction-text {
          width: 102%;
          margin-left: -1.5%;
      }
  
  
      body.dosing.btc-hcp .callout.dosing-box1-callout {
          display: flex;
          align-items: center;
          justify-content: center;
          height: 77px;
      }
      
      body.dosing.btc-hcp .dosing-box1-callout::before {
          top: 50%;
          transform: translateY(-50%);
      }
  
      body.dosing.btc-hcp .dosing-box1-callout p {
          padding-right: 25px!important;
      }
  
      body.safety.btc-hcp h2#subhead-safety {
          width: 101%;
      }
  
      .discontinuation-rates-sec .img-box-padding {
          padding: 0;
          margin: -15px auto -10px!important;
      }
  
      body.safety.btc-hcp .ef-immune-mediated-ar > .page-content h2:nth-child(1) {
          width: 104%;
      }
  
      .box-survival {
          padding-left: 0!important;
          padding-right: 0!important;
      }
      
      .box-survival img.desktop-only.img-box-padding {
          width: 100%;
          margin-left: -3px!important;
          margin-bottom: -10px;
      }
  
      body.efficacy.btc-hcp .ef-orr-dor .list-sec + .box-image img {
          width: 100%;
          margin: 25px 0 20px;
      }
      
      body.efficacy.btc-hcp .ef-orr-dor .list-sec + .box-image {
          padding-left: 6px!important;
          padding-right: 5px!important;
      }
  
      body.efficacy.btc-hcp .box-image.key-table {
          /* padding-left: 0!important; */
          padding-right: 0px!important;
      }
      
      body.efficacy.btc-hcp .box-image.key-table img {
          /* width: 100%;
          padding: 20px 0 15px; */

          width: 100%;
          padding: 5px 0 15px;
  
      }
  
      body.dosing.btc-hcp #dosage-txt-2 + .list-sec {
          width: 102%;
      }
      
  
  }
  @media screen and (min-width: 768px) {
   table.customTable.desktop-only {
       display: table;
   }
  .btc-hcp.efficacy .nccn-category-bar{
      margin-left:0px;
                      width:97%;
                  }
    .btc-hcp.efficacy .ml-20{
      margin-left:20px;
                  }
  .btc-hcp.efficacy .box-heading{
                      margin-top:-30px;
                  }
  .btc-hcp.efficacy .mt-10{
      margin-bottom:10px;
                  }
  .btc-hcp.efficacy .progression-free-survival-sec .cssul.arrow-list{
          padding-left: 43px;
          }
   .discon-imfi-blck p:nth-child(6) span.treat-body {
       margin: 29px 25px 29px;
   }
   .with-imfi-blck p:nth-child(7){
       padding-bottom: 28px;
   }
   .ef-stud-bullet-sec-11 .bullet-list, .ef-stud-bullet-sec-11 p {
       margin-left: 60px;
   }
   .analysis-sec p {
       font-size: 17px;
   }
   .analysis-sec p span.ff-rr {
       text-align: center;
   }
   .sf-treat-modi-table .customTable td {
       padding: 1.5px 7px;
   }
   .sf-treat-modi-table th:nth-child(2) {
       width: 43%;
   }
	.reduction-text.customMargin.customSize {
        font-size: 16px;
    }
  } 
  sup {
    top: -0.4em;
    font-size: 64%;
}

sup.sup5 {
    position: absolute;
    right: 377px;
    bottom: 10px;
    top: auto !important;
}
  @media screen and (max-width: 991px){
    .dosing .scroll-header-wrapper,
    .additional-analyses .scroll-header-wrapper,
	.efficacy .scroll-header-wrapper {
        overflow: initial;
        margin-left: 0;
        margin-right: 0;
    }
    .dosing .scroll-header ,
	.additional-analyses .scroll-header,
    .efficacy .scroll-header {
        width: max-content;
    }
     .dosing p.bar {
        width: 622px;
        background: #EDEDED;
    }  
	/*Bharathi's changes*/
	.additional-analyses .mobile-swipe-chart-eff-pres-chart1 { overflow: scroll; }
	.additional-analyses .mobile-swipe-chart-eff-pres-chart1 .scroll-header-wrapper p.bar {
        width: 642px;
    }

	.efficacy .survival-prespecified-chart .scroll-header-wrapper p.bar {
            width: 707px;
        }


	.additional-analyses .mobile-swipe-chart-eff-pres-chart-ttd,
	.efficacy .survival-prespecified-chart{ 
    	overflow: scroll;
	}

	.additional-analyses .mobile-swipe-chart-eff-pres-chart-ttd .scroll-header-wrapper{
		margin-bottom: 10px;
	}
	.additional-analyses .mobile-swipe-chart-eff-pres-chart-ttd .scroll-header-wrapper p.bar {
        width: 568px;
    }
	/*Bharathi's end changes*/
      .about-btcs #column-txt-heading{font-size:16px; line-height:20px;}
      body.efficacy.btc-hcp .reference-section {
          padding-right: 9px;
      }
  
      body.efficacy.btc-hcp  h2#eff-head-1 + .box-image {
          margin-bottom: 40px;
      }
  
      .btc-hcp .switch-section a:before,.switch-section a:after {
          top: 50%;
          transform: translateY(-50%);
      }
      
      .btc-hcp .switch-section a.switch-after:before {
          transform: translateY(-50%) rotate(180deg)!important;
      }
      
      .btc-hcp .switch-section .switch-after {
          text-align: right;
          display: flex;
          align-items: center;
      }
  
      .btc-hcp .switch-section .switch-before {
          display: flex;
          align-items: center;
      }
  
      .box-survival img.desktop-only.img-box-padding + img {
          padding: 0;
          margin-bottom: 10px;
      }
  
      body.dosing.btc-hcp p.footnotes.fn-2 {
          margin-top: 5px;
      }

      .btc-hcp .switch-section a{
        font-size: 16px;
        line-height: 20px;
      }
    }
  
  @media screen and (max-width: 767px) {
    .efficacy.btc-hcp .reduction-text.customMargin {
        font-size: 20px;
        width: 90%;
    }

    .efficacy.btc-hcp .updated-os-text{
        margin-top: 10px;
	}

    body.efficacy .sd-and-pc .footnotes sup {
        top: -0.3em;
    }
    p.footnotes.lp-01 sup {
        top: -0.5em !important;
    }
    sup.sup5 {
        right: 63px;
        bottom: 10px;
        top: auto !important;
    }
    p.footnotes.footnote1.ftnote {
        letter-spacing: 0.2px;
    }
  /* UPDATE */
	p.bar {
        background: #00000067 !important;
      }

     .efficacy.btc-hcp p.reduction-text.customSize2 sup.per-top {
        font-size: 15px;
    }
    
    .efficacy.btc-hcp p.reduction-text.customSize2 span.big-txt {
        font-size: 24px;
        line-height: 26px;
    }
    .efficacy.btc-hcp p.reduction-text.customSize2 span.red-txt {
        font-size: 16px;
    }
    .efficacy.btc-hcp p.reduction-text.customMargin span.red-txt {
        font-size: 14px;
    }


  .ds-btc.table-block th, .ds-btc.table-block td {
    white-space: nowrap;
    /* font-size: 10px;
    line-height: 11px; */
    font-size: 13px;
    line-height: 15px;
}
.dosage-modifi .border-r-b-none th{
    font-size: 12px !important;
}
.dosage-modifi td.tb-sticky{
    padding: 0 20px 0 30px;
}
.laboratory-abnormalities tr.border-r-b-none th {
    font-size: 14px;
}
.laboratory-abnormalities span.extended-text {
    width: 198px !important;
    display: block;
}
.laboratory-abnormalities td.span-cell.tb-sticky {
    padding-left: 5px !important;
    max-width: 213px !important;
    white-space: nowrap !important;
    font-size: 14px;
}
.laboratory-abnormalities-mob th, .laboratory-abnormalities-mob td {
    font-size: 12px !important;
}
.laboratory-abnormalities .laboratory-abnormalities-mob span.extended-text {
    width: 161px !important;
}
.ds-btc.table-block td:first-child {
    max-width: 150px;
    white-space: normal;
}
.ds-btc.table-block.dosage-modifi td:first-child {
    white-space: nowrap;
    max-width: 165px;
    width: 165px;
    word-break: break-all;
}
.dosage-modifi td.span-cell.tb-sticky.br-none {
    text-align: left;
    padding: 1.5px 0px;
}
.eff-pres-chart td.span-cell.tb-sticky {
    max-width: 190px;
}
.eff-pres-chart span.extended-text {
    width: 230px;
    display: block;
}
.dosage-modifi .extended-text {
    /* display: block; */
    /* width: 300%; */
    text-align: left;
    padding: 5px 10px;
}
.dosage-modifi .span-row, .dosage-modifi .span-row td {
    background: #cde3eb;
    border-right: none;
}
.dosage-modifi td {
    font-size: 12px !important;
    line-height: 12px !important;
}
.tb-sticky {
position: sticky;
left: 0;
z-index: 2;
  }

  .tbl_pati-char .span-row td:nth-child(1) {
    width: 204px;
    max-width: 204px;
    display: block;
}
.tbl_pati-char .span-row td:nth-child(1) .extended-text {
    width: 100%;
}
.tbl_pati-char .span-row td:nth-child(2), .tbl_pati-char .span-row td:nth-child(3) {
    padding: 7px 20px;
}
/*body.efficacy .box-light-blue.box-survival .scroll-header-wrapper .scroll-header{
	width: 273%; 
}*/

.btc-hcp  .eff-pres-chart .left-img {
    height:auto;
    margin: 0px;
    width: 350px;
    margin-top:2px;
  }

  .btc-hcp .box-image img {
    width: 100%;
    max-width: 100%;
  }
.btc-hcp .box-image img{
    width:auto;
    /* margin-top: 55px; */
}
#dosing-box-1 img.mobile-only {
    margin: -10px -15px 0;
}
.box-image-rr img {
    margin: 10px 0 10px !important;
}
    .btc-hcp .box-image img.vs-empty {
        width: 28px;
        height: 28px;
		max-width: 28px;
    }

.btc-hcp .eff-pres-chart .right-img {
    padding-left:5px;
    margin-top:4px
}

    .btc-hcp .overall-survival-sec .eff-pres-chart .right-img {
        padding-left: 0;
        /*width: 399.3px;*/
    	width: 496px;
        overflow-x: scroll;
    }

	.btc-hcp.efficacy .overall-survival-sec .eff-pres-chart .right-img {
        overflow-x: initial;
        width: auto !important;
        margin: 4px 0 0 158px !important;
    }


	.btc-hcp.efficacy .overall-survival-sec .mobile-swipe-chart .eff-pres-chart .left-img {
    	position: absolute;
        left: 40px;
        width: 160px;
	}

	.btc-hcp.efficacy .overall-survival-sec .mobile-swipe-chart .eff-pres-chart .left-img img {
        max-width: 160px;
        margin-top: 0.14em;
    }                    


	/*body.additional-analyses .mobile-swipe-chart .eff-pres-chart .left-img {
        padding-left: 0;
        width: 135px;
    }

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart .left-img img {
		max-width: 135px;
    	width: 135px;
	}

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart .right-img {
        padding-left: 0;
        width:496px;
        overflow-x: scroll;
    }

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart .right-img img {
		max-width: 496px !important;
    	width: 496px !important;
    }

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart1 .left-img {
        width: 83px;
    }
    
    body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart1 .left-img img {
        max-width: 83px;
        width: 83px;
    }*/

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart1 .left-img {
        padding-left: 0;
     	margin-top: 1px;
		max-width: 135px !important;
        width: 135px !important;
    	position: absolute;
    	left: 40px;
    }

    body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart1 .left-img img {
        max-width: 135px !important;
        width: 135px !important;
        margin-top: 2px !important;
    }

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart1 .right-img {
        padding-left: 0;
    	width: auto !important;
    	margin: 0 0 0 135px !important;
    	overflow: initial;
    }

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart1 .right-img img {
		max-width: 779px !important;
    	width: 779px !important;
    	margin-top: 3px;
    }


	body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart-ttd .left-img {
        padding-left: 0;
        max-width: 179.5px !important;
        width: 179.5px !important;
     	margin-top: 1px;
    	position: absolute;
    	left: 40px;
    }

    body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart-ttd .left-img img {
        max-width: 179.5px !important;
        /*width: 179.5px !important;*/
        margin-top: 0px !important;
    }

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart-ttd{
    	margin-bottom: 10px;
	}

	body.additional-analyses .mobile-swipe-chart .eff-pres-chart.eff-pres-chart-ttd .right-img {
        padding-left: 0;
    	/*width: auto !important;*/
    	/*margin: 0 0 0 179px !important;*/
    	margin: 1px 0 0 179px !important;
    	overflow: initial;
    }

	.eff-pres-chart .right-img img {
        max-width: 100% !important;
    }
	body.additional-analyses .eff-pres-chart .right-img img {
          max-width: 661px!important;
    }
    body.efficacy .eff-pres-chart .right-img img {
        /*max-width: 732.5px !important;
        width: 732.5px;*/
    	/*max-width: 693px !important;
        width: 696px !important;
        margin-left: 2px;*/
        max-width: 822px !important;
    width: auto !important;
    margin-left: 2px;
    }

  .btc-hcp p.box-heading {
    font-size: 16px;
    line-height: 18px;
  }
.btc-hcp p.box-heading {
    padding: 0px 10px 10px 15px;
    width: auto;
}
  
p#dosing-box-2 {
    margin-top: -30px;
    padding: 0 6px 0 15px;
}
.box-heading.box-heading-post1{
    max-width: 228px;
}
p.box-heading.box-heading-la {
    padding-right: 0;
    letter-spacing: -0.6px;
    max-width: 100% !important;
    width: 265px !important;
}
.btc-hcp .box-heading.box-heading1{
    padding: 0px 0px 10px 15px;
    width: 280px;
    letter-spacing: -0.2px;
}
   .about-btcs.btc-hcp p.box-heading {
        width: fit-content;
}
  .btc-hcp p.eyebrow {
   font-size: 16px;
   line-height: 18px;
  }

  .dosing .prescribing-info {
    padding-right: 10px;
  }
  .pl-8{
    padding-left: 8px !important;
    margin-bottom: 5px;
  }
  p.mtop_20.mbottom_20.prescribing-info {
    font-size: 18px;
    line-height: 24px;
}
.mt20{
    margin-top: 20px;
}
.mb-15{
    margin-bottom: 15px !important;
}
	.btc-hcp p.footnotes{line-height: 17px; margin-left: 0;}
    body.safety.btc-hcp.mobile p.footnotes.ml-7.mb0.ls-0 {
        margin-left: -16px !important;
        padding-right: 10px;
    }
    p.footnotes.ml-7.mb0.ls-0 .single-footnote sup {
        left: 0;
    }
    
    /* p.footnotes.ml-7.mb0.ls-0 span.single-footnote {
        margin-left: -3px !important;
    }
    p.footnotes.ml-7.mb0.ls-0 .single-footnote sup {
        left: 0px;
    } */
    p.footnotes.mr6.mb35 {
        margin-bottom: 0;
    }
    .ft-note p.footnotes:nth-child(8), .ft-note p.footnotes:nth-child(9), .ft-note p.footnotes:nth-child(8), .ft-note p.footnotes:nth-child(10) {
        margin-left: 0;
        text-indent: -4px;
    }
    .pr-11{
        padding-right: 11px;
    }
    p.footnotes.lp-01{
        letter-spacing: 0.2px !important;
    }
        
    .dosing.btc-hcp p.footnotes{
        letter-spacing: -0.53px;
        padding-right: 5px;
        margin-left: 7px;
    }
    p.footnotes.pr-26.ml-0 {
        margin-left: 6px !important;
    }
    .pr-0{
        padding-right: 0 !important;
    }
    p.footnotes.ls-55 {
        letter-spacing: -0.55px !important;
        padding-right: 0 !important;
    }
    .pr-9{
        padding-right: 9px!important;
    }

  .btc-hcp .page-content h2 {
   font-size: 22px;
   line-height: 27px;
   letter-spacing: -0.44px;
   /* padding: 10px 0 0; */
   padding:0;
   margin-top: 22px;
  }
  .heading.heading-h2 {
    margin: 0 auto !important;
    font-size: 24px !important;
}
  .btc-hcp .data-compare {
   width: 100%;
  }
  
  .btc-hcp .data-red-txt, .data-red-txt p {
  font-size: 15px;
  }
  
  .btc-hcp .data-comp-bottom.data-grey-txt {
   font-size: 15px;
  }
  
  .btc-hcp .reduction-text {
    font-size: 22px;
    line-height: 13px;
    margin: 0 auto;
    width: 100%;
  }
  .red-txt {
    font-size: 14px;
    line-height: 14px;
	display: block;
    color: #07729b;
  }

	.progression-free-survival-sec .red-txt { display: inline;}

  .gray-txt {
    font-size: 15px;
    line-height: 22px;
  }
  
  .txt-hr-light {
    font-size: 12px;
  
  }
  
  .about-btcs.btc-hcp  ul.light-txt {
   padding-left: 67px;
   margin-bottom: -10px;
  }
  
  #txt-heading {
   padding-left: 25px;
  }

   hr.vs-line {
    margin: 5px 0 0;
    /* border-top: 1.5px solid #003262; */
  }
  .callout-wrap {
    flex-direction: column;
    padding: 40px 20px 14px 20px;
    border: 1px solid #003262;
    margin: 50px auto 20px;
    position: relative;
   }
  .callout-wrap img {
    width: 62px;
    height: 62px;
    margin-right: 0;
    position: absolute;
    top: -31px;
   }
   p.callout-head {
    font-size: 21px;
    line-height: 24px;
   }
   .callout-wrap-86 p.callout-head {
    /* font-size: 18px; */
    line-height: 21px;
    padding-right: 10px;
    margin-bottom: 5px;
    }
    .efficacy .callout-copy p {
        margin-bottom: 5px;
        letter-spacing: -0.18px;
    }
    .callout-txt .fw-bold span.text-nowrap {
        white-space: normal;
    }
    .mt-5{
        margin-top: 5px;
    }
    .callout-wrap-86 p.callout-txt {
        /* padding-right: 50px; */
        letter-spacing: -0.2px;
    }
   .callout-copy p{
    padding-right: 0;
    margin-bottom: 20px;
   }
   p.callout-head.font18{
    /* font-size: 18px; */
    line-height: 21px;
    margin-bottom: 2px;
    padding-right: 1px;
   }
   .font15{
    font-size: 15px !important;
    letter-spacing: -0.2px;
   }
   p.callout-txt{
    margin-bottom: 0;
   }
   ul.light-blue-list{
    padding-right: 15px;
    margin-bottom: 24px;
   }
   ul.light-blue-list li{
    font-size: 16px;
    line-height: 18px;
   }
   .pr-20 {
    padding-right: 0 !important;
}
   .mt33{
    margin-top: 33px !important;
   }
   .arrow-callout{
    /* padding: 18px 0 18px 34px; */
    padding: 18px 8px 18px 30px;
    margin: 0px 0 25px auto;
    margin-top: 15px;
   }
   .arrow-callout p{
    font-size: 16px;
    line-height: 18px;
   }
   .arrow-callout:before {
    width: 42px;
    height: 25px;
    }

    /* body.efficacy.btc-hcp.mobile p.eyebrow, body.efficacy.btc-hcp.mobile h2 {
        margin-left: -16px;
    }
     body.efficacy.btc-hcp.mobile .page-content {
        margin: 0 15px 0 15px;
    }
    body.efficacy.btc-hcp.mobile .arrow-callout {
        margin-left: 20px;
    } */
   .learn-how{
    flex-direction: column;
    margin: 10px 0 40px;
   }
   .learn-how a {
    font-size: 16px;
    line-height: 20px;
    margin-bottom: 21px;
    padding-left: 30px;
    padding-right: 18px;
   }
   .learn-how a::after{
    font-size: 13px;
    padding-left: 10px;
    padding-top: 2px;
   }
 
   .pr-26{
    padding-right: 26px !important;
   }
  
  /* b#column-txt-heading {
   position: relative;
   left: -8%;
  } */
  
  
  
  .efficacy.btc-hcp .nccn-category-bar {
    display: flex;
    border-top: 1px solid #707070;
    border-bottom: 1px solid #707070;
    background-color: #7099D326;
    position: relative;
    height: auto;
    margin-left: auto;
    margin-right: auto;
    margin-bottom: 80px;
    margin-top: -50px;
    align-items: center;
    left: 0;
    right: 0;
    padding-left: 0;
    padding-top: 10px;
    padding-bottom: 20px;
  }
  
  
  .efficacy.btc-hcp .nccn-expanded-text {
    padding-top: 15px;
    margin-left :-2px;
    padding-right: 4px;
  }
  .efficacy.btc-hcp .nccn-expanded-text p {
    margin-bottom: 0px;
    font-family: 'Ubuntu', sans-serif;
    color: #003262;
    font-size: 14px;
    line-height: 16px;
    margin-left: 13px;
    font-weight: 400;
  }
  
  .efficacy.btc-hcp .nccn-category-text {
    font-size: 17px;
    color: #003262;
    font-family: 'Ubuntu', sans-serif;
    line-height: 13px;
  }
  .efficacy.btc-hcp .category-text {
    font-size: 13px;
    font-weight: 700;
    font-family: 'Ubuntu', sans-serif;
    width: 83px;
    display: inline-block;
  }
  
  .efficacy.btc-hcp .nccn-category-text::after {
    margin-left: 10px;
  }
  
  .efficacy.btc-hcp .nccn-category-text::after {
    content: " ";
    border-right: 1px solid #00294E;
    position: absolute;
    top: 5%;
    bottom: 5%;
    height: 90%;
  }
  
  .btc-hcp .page-heading {
    margin: 0 15px;
  }
  
  .btc-hcp .ef-anchor-sec {
    margin: 0 0 20px 15px;
    max-width: 342px;
    display: flex;
    flex-direction: row;
  }
  
  img.mobile-only.pinch-zoom-txt {
   max-width: 120px;
   margin: 0 auto;
   padding-top: 20px;
   padding-bottom: 15px;
  }
  
  .sub-head-topaz {
   font-size: 18px !important;
       margin-top: 20px !important;
  }
  
  
  
  .psa-sec {
   display: inline-flex;
   align-items: center;
   width: 100%;
   /* margin-bottom: 10px;
   flex-direction: column; */
   margin-bottom: 0px;
  }

  body.dosing.btc-hcp.mobile .psa-sec:last-child {
   margin-bottom: 10px;
  }	

  .ds-prep-str-ad ul.arrow-list {
   margin-top: 20px;
  }
  .psa-sec img {
    width: 60px !important;
    margin-right: 15px;
    max-width: 62px;
  }

  .ds-prep-str-ad ul.arrow-list {
   margin-top: 30px;
   align-self: flex-start;
   margin-left: -15px;
   padding-left: 40px;
  }
  .ds-prep-str-ad .page-content-dosing ul.arrow-list{
    padding-left: 9px
  }
	body.dosing.btc-hcp.mobile .ds-prep-str-ad .page-content-dosing ul.arrow-list {
        margin-top: 15px;
    }

  .ds-prep-str-ad h1.heading {
   font-size: 24px;
   font-family: 'ubuntu';
   color: #AC182E;
  
  }
  
  #eyebrow-dosing {
   font-size: 16px !important;
   margin-top: 0px;
  }
  
  #subhead-dosing {
   font-size: 16px !important;
   margin-top: 20px !important;
   color: #555555;
  }
  
  .dosing.btc-hcp .callout p {
   padding: 10px 35px;
  }

  h2#dosing-subhead-2 {
   font-size: 18px;
  }
  
  ul#no-icon-margin {
    padding-left: 0;
    padding-right: 10px;
    margin-bottom: 20px;
  }
  
  
  .two-columns-txt-btc {
   flex-direction: column;
  }
  b#column-txt-heading {
   font-size: 14px;
  }
  
  .btc-hcp .page-heading {
    margin: 0 15px;
    padding: 15px 0 15px;
  }
  
  h2.sub-head-topaz {
   padding: 0 !important;
   margin: 0;
   font-size: 18px;
   line-height: 22px !important;
  }
  
  .btc-hcp .callout p {
   padding: 10px 34px;
  }
  
  #txt-nowrap-2 {
   white-space: wrap;
  }
  
  
  .btc-hcp p.eyebrow {
   margin-bottom: -15px;
    padding-right: 1px;
  }
  
  #eff-head-1 {
   letter-spacing: -0.88px !important;
  }
  .pr-5{
    padding-right:5px !important
  }
  .pr-10 {
    padding-right: 0;
}
  span.big-txt {
    font-size: 19px;
    line-height: 22px;
  }
  
  .percentage-number {
    font-size: 30px;
    font-weight: 900;
    line-height: 22px;
    position: relative;
    left: 5px;
    letter-spacing: -0.9px;
  }
  
  #dosing-box:before {
    top: -3px;
  }
  
  p.disclaimer-eyebrow {
    /* letter-spacing: -0.27px; */
    letter-spacing: normal;
    }
  
    h1#dsg-sp1 {
      margin-top: -.5rem;
  }
  
  #subhead-safety {
    margin-top: .5rem !important;
  }
  
  .safety .patients-permanently-discontinued {
    padding: 10px 10px 10px 17px;
   }
  .safety .patients-permanently-discontinued h3,
  .safety .patients-permanently-discontinued h2 {
    letter-spacing: -0.84px;
    margin: 0 0 10px;
  }

  
  .safety .patients-permanently-discontinued h2{
     font-size: 21px;
     line-height: 25px;
  }



  /* END */


   .btc-table-section {
       margin: 0 auto;
       max-width: 355px;
   }
   .chart-img img.mobile-only, .chart-img {
       margin: 0 auto;
   }
   .ef-orr-Chart.chart-img img {
       display: block;
   }    
   .btc-hcp main#maincontent {
       margin-top: 94px;
   }
   .subpage-banner {
       height: 90px;
   }
   /* .page-content {
       padding: 0 10px 0 10px;
       overflow: hidden;
   } */
   .sec-header-container {
       padding-top: 4px;
   }
   p.nccn-txt {
       margin-top: 5px;
       font-size: 28px;
   }
   .banner-liv-img {
       margin: 0 15px 0 -55px;
   }
   .subpage-banner .banner-subhead-block hr {
       width: 25px;
   }   
   .banner-liv-img img {
       max-width: 63px;
   }
   p.banner-heading {
       font-size: 42px;
   }
   .subpage-banner p.banner-subhead {
       font-size: 10px;
       max-width: 143px;
   }
   .ef-dor-Chart {
       margin-bottom: 10px;
   }
   .analysis-sec p span.sot-reg {
       display: block;
   }
   .hr-footnote p, .os-pfs-head p {
       font-size: 17px;
   }
   .red-lined hr {
       width: 10%;
   }
   .sf-treat-modi-table .red-lined hr {
       width: 5%;
   }
   .overall-survival-sec .os-pfs-head hr {
       width: 10%;
   }
   .ef-OS-Forrest-Plot-Chart hr {
       width: 41%;
   }
   table.customTable {
       margin-top: 10px;
       letter-spacing: -0.5px;
   }
   .customTable th, .customTable td {
       padding: 4px 4px;
   }
   .sec-header {
       padding: 5px 11.5px 5px 11.5px;
   }
   .overall-survival-sec .eyebrow-txt {
       margin-top: 25px;
   }
   .overall-survival-sec .analysis-sec, .progression-free-survival-sec .analysis-sec {
       margin-top: 10px;
       padding-top: 10px;
   }
   .ef-orr-Chart img {
       margin: 17px auto 50px;
   }
   .analysis-sec {
       flex-direction: column;
   }
   .analysis-sec p {
       font-size: 17px;
       line-height: 20px;
       text-align: center;
   }
   .analysis-sec img.mobile-only {
       margin: 0 auto;
       display: block;
   }
   .main-txt {
       font-size: 18px;
       line-height: 21px;
       margin: 10px auto;
   }
   .ef-mtr-Chart .footnotes {
       margin: 30px auto 33px;
   }
   .ef-dor-Chart hr {
       width: 38%;
   }
   .callout-sec p {
       letter-spacing: -0.3px;
       margin-right: 0;
   }
   span.nccn-subtxt {
       font-size: 8px;
       letter-spacing: 0.06px;
       line-height: 12px;
       margin-top: 0;
   }
   .ef-orr-dor .sec-header-container {
       margin-bottom: 34px;
   }
   .ef-orr-mtr-img-sec {
       flex-direction: column;
       width: 100%;
   }
   .ef-orr-mtr-img-sec div{
       width: 100%;
   }
   .ef-orr-Chart {
       margin-right: 0px;
   }
   .ef-bullet-img-blck, .ef-bullet-bullet-blck {
       flex-direction: column;
   }
   .ef-stud-eligibility-section p.bullet-heading {
       text-align: center;
   }
   .ef-bullet-img-blck {
       padding-bottom: 15px;
   }
   .ef-stud-eligibility-section {
       padding-bottom: 5px;
   }
   .ef-stud-bullet-sec-4 {
       padding-bottom: 15px;
   }
   .ef-stud-bullet-sec-1, .ef-stud-bullet-sec-2 {
       width: 100%;
   }
   .ef-stud-bullet-sec-2 {
       border-bottom: 1px solid #74A9D9;
       margin-bottom: 30px;
   }
   .ef-mtr-Chart .table-heading {
       margin: 20px 0;
   }
   .sf-ar-table td.span4, .sf-lab-abnormalities-table td.span4 {
       background-color: #E6EAF1;
       font-size: 15px;
       line-height: 16px;
       text-align: center;
   }
   .sf-ar-table .customTable td:nth-child(1) {
       text-align: center;
   }
   .sf-lab-abnormalities-table .mobile-only.customTable th, .sf-lab-abnormalities-table .mobile-only.customTable td {
       width: 10%;
       text-align: center;
   }
  
   .ef-key-patient-char-table .customTable td:nth-child(1) {
       text-align: center;
   }
   .rd-compare-sec {
       flex-direction: column;
       align-items: center;
   }
   .OS-KM-Curve-Chart {
       margin: 15px auto 33px;
   }
   .overall-survival-sec .callout-sec {
       margin: 26px auto;
   }
   h1.heading.os-result {
       margin: 35px auto 26px;
   }
  
   .psa-sec img {
       width: 49px;
   }
   .sf-treat-modification-section {
       flex-direction: column;
   }
   .sf-treat-modification-section div {
       width: 100%;
       margin: 0;
   }
   .ef-key-patient-char-table .table-heading hr {
       width: 13%;
   }
   /*.comp-sepline-sec {
       transform: rotate(90deg);
       max-height: 25px;
       margin-left: 180px;
   }*/
   .rd-start-with, .rd-continue {
       width: 100%;
       max-width: 355px;
   }
   p.rd-compare-head {
       font-size: 20px;
       line-height: 22px;
   }
   .treatment-modifications-sec p.sec-header-container {
       margin: 50px auto 25px;
   }
   .dis-rate-section {
       padding: 10px 25px 0px;
   }
   .sf-lab-abnormalities-table .customTable {
       margin-bottom: 35px;
   }
   .sf-lab-abnormalities-table .table-heading hr {
       width: 33%;
   }
   .dis-rate-comp p {
       line-height: 25px;
   }
   .sf-ebook-blck p {
       max-width: 306px;
       margin: 0 auto 20px;
   }
   td.chart-body {
       font-size: 15px;
       color: #173A64;
       font-family: 'RobotoCondensed-Bold';
   }
   .customTable.mobile-only th:first-child {
       border-left: 0;
   }
   th.bg-white-cell {
       border-top: 0.5px solid #7099D3;
   }
   .with-imfi-blck hr {
       width: 25%;
   }
   .discon-imfi-blck .red-lined.table-heading.treat-head hr {
       width: 10%;
   }
   p.treat-last {
       margin-bottom: 30px;
   }
   .sf-treat-modification-section .table-heading {
       margin-bottom:20px;
   }
   .rd-compare-sec hr {
       width: 30%;
   }
   .comp-sepline-sec img {
       margin: 25px auto;
   }
   .red-lined hr {
       height: 1px;
   }
   .dis-rate-comp p span.sot-reg {
       display: block;
       margin-top: 5px;
   }
   .progression-free-survival-sec .os-pfs-head.in-w hr {
       width: 16%;
   }
   /***scroll-table-styling***/
   .scroll-header-wrapper {
       overflow-x: auto;
   }
   .scroll-header {
       display: flex;
       background: #EDEDED;
       align-items: center;
       justify-content: space-between;
       border: 0.5px solid #9F9F9F;
       width: 181%;
   }
   .scroll-header p {
       font-family: Roboto-bold, sans-serif;
       padding: 6px 0px;
       margin: 0;
       font-size: 12px;
       margin-right: 8px;
       margin-left: 8px;
       margin-top: 1px;
   }
   .scroll-header i {
       border: solid #555555;
       border-width: 0 2px 2px 0;
       display: inline-block;
       padding: 2px;
       top: -1px;
       position: relative;
   }
   i.arrow.left, i.arrow.right {
       margin-right: 5px;
   }
   i.arrow.right {
       margin-left: 5px;
   }
   .right {
       transform: rotate(-45deg);
       -webkit-transform: rotate(-45deg);
   }
   .left {
       transform: rotate(135deg);
       -webkit-transform: rotate(135deg);
   }
   p.bar {
       width: 55px;
       height: 11px;
       background: #BEBEBE;
   }
   .combine-img {
       display: flex;
   }
   .mobile-swipe-chart .left-img {
       margin-top: 57px;
   }
   .mobile-swipe-chart .left-img img {
       max-width: 156px;
       margin-top: -1px;
   }
   .mobile-swipe-chart .right-img {
       overflow-x: auto;
   }
   .right-img::-webkit-scrollbar {
       display: none;
   } 
   .sf-treat-modi-table .bb-fff {
       border-bottom: 0.5px solid #ffffff;
   }
   .sf-treat-modi-table td.chart-body {
       font-family: 'HelveticaNeueLTStd-LtCn';
       color: #2B2E34;
   }
   .switch-section a.two-line {
       padding: 20px 50px 30px 0px;
       text-align: right;
   }
   hr.os-data-hr {
       width: 8%;
   }
   .progression-free-survival-sec .table-heading hr {
       width: 18%;
  }
  div#dosing-box-1{
    padding: 0px !important;
    margin: 35px 0;
    border: none;
    max-width: 100%;
  }
  #dosing-box:before{
    content: none;
  }
} 



@media screen and (max-width: 680px) {
    ul.patients-characteristics {
        /* flex-direction: column; */
        flex-wrap: wrap;
        margin:15px 0 20px;
        width: 93%;
    }
    ul.patients-characteristics li {
        list-style-type: none;
        width: 47%;
        text-align: center;
    }
    ul.patients-characteristics li img {
        width: 156px;
        height: 156px;
    }
    ul.patients-characteristics li:first-child, ul.patients-characteristics li:nth-child(2) {
        margin-bottom: 20px;
    }
    .c100{
        scale: 0.94;
    }

}

/* @media screen and (max-width: 440px){
    .tbl_pati-char .span-row td:nth-child(1) {
        width: 188px;
        max-width: 188px;
    }
}
@media screen and (max-width: 430px){
    .tbl_pati-char .span-row td:nth-child(1) {
        width: 204px;
        max-width: 204px;
    }
}   */
  @media screen and (max-width: 320px){
   table.customTable {
       letter-spacing: -0.8px;
   }
   .customTable th, .customTable td {
       padding: 4px 1px;
   }
   .tag-purple-color {
       border: 0.7px solid #5b305d;
       border-top: none;
   }
  
   .ef-OS-Forrest-Plot-Chart .efficacy-page .right-img img {
       max-width: 653px;
   }
   .ef-orr-dor .sec-header {
       max-width: 198px;
   }
   .table-heading p, .rd-compare-sec .table-heading p {
       font-size: 15px;
   }
  
   .dis-rate-comp p.red-txt {
       padding-right: 30px;
   }
   .dis-rate-comp p {
       padding-left: 30px;
   }   
  }
  @media screen and (max-width: 328px){
   .dis-rate-comp p.red-txt {
       padding-right: 30px;
   }
   .dis-rate-comp p {
       padding-left: 30px;
   }
   .switch-section a.two-line {
       padding: 20px 50px 30px 0px;
   }
   p.rd-comp-footnote.rd-comp-foot-1 {
       margin-left: 35px;
   }
   .ef-orr-dor .sec-header-container {
       display: flex;
       padding: 0;
   }
   .banner-liv-img {
       margin: 0 10px 0 -30px;
   } 
  }
  @media screen and (-ms-high-contrast: active), (-ms-high-contrast: none){
   .banner-liv-img {
       top: 0;
   }
   .analysis-sec hr {
       right: 20px;
       left: 20px;
       margin:0;
   }
  }
  @media screen and (max-width: 355px){
   .chart-img img, .ef-stud-bullet-sec-11 img.mobile-only {
       max-width: 300px;
   }
   .chart-img .efficacy-page img {
       max-width: fit-content;
   }        
   .switch-section a {
       padding: 30px 39px;
   }
  }