/* -- Efficacy New CSS -- */

/* Global */

.main-container {
  margin: 0 auto;
  max-width: 950px;
  background: #fff;
}
.pink-text {
  color: #eb00ff;
}
.reference-section {
  color: #555;
}
.colorac182e{
	color:#ac182e;
}
.fw-700{
	font-weight:700!important;
}
section.page-heading .inner-wrap {
  padding-left: 10px;
}

section.page-heading {
  padding: 40px 0;
}

section.page-heading {
  padding-bottom: 51px;
}

section.inner-content {
  max-width: 720px;
  margin: 0 auto;
}
sup.sup-reg {
  font-size: 55%;
  top: -0.65em;
}
p.page-heading__label {
  /*margin: 64px 0 10px;*/
   margin: 100px 0 10px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #003865;
}

h1.page-heading__title {
  margin: 0 0 30px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 38px;
  font-style: normal;
  font-weight: 700;
  line-height: 48px;
  color: #00284e;
}

span.page-heading__emphasis {
  font-size: 48px;
  line-height: 48px;
}

h2.jump-links__title {
  margin: 0 0 10px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #00284e;
  margin-right: -5px;
}

.jump-links {
  display: flex;
  gap: 10px;
  margin-bottom: 42px;
  margin-left: 4px;
}

a.jump-links__btn {
  display: flex;
  align-items: center;
  column-gap: 10px;
  white-space: nowrap;
  height: 45px;
  margin: 0;
  padding: 10px 15px;
  box-shadow: inset 0 0 0 2px transparent;
  font-family: Ubuntu;
  font-size: 18px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  background: #ac182e;
  color: #f0f5fc;
  box-sizing: border-box;
}

.jump-links__icon {
  display: block;
  width: 16px;
  height: 11px;
  color: #fff;
}

a.jump-links__btn:hover {
  text-decoration: none;
  box-shadow: inset 0 0 0 2px #ac182e;
  background: #fff;
  color: #ac182e;
}

a.jump-links__btn:hover .jump-links__icon {
  color: #ac182e;
}

p.jump-links_disclaimer {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 12px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #555;
}

.section-heading {
  background: #fff;
  border-top: 1px solid #00284e;
  padding-bottom: 30px;
}
.section-heading.section-heading-sdpc {
  padding-bottom: 40px;
}
.section-heading p {
  margin: 0;
  padding: 10px 0 10px 110px;
  border-bottom-left-radius: 16px;
  border-bottom-right-radius: 16px;
}

.section-heading span {
  padding: 10px 20px;
  border-bottom-left-radius: 16px;
  border-bottom-right-radius: 16px;
  font-family: Ubuntu;
  font-size: 18px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  background: #ac182e;
  color: #fff;
}

p.section-head:has(#efs) {
  padding-left: 118px;
}

p.text-eyebrow {
  margin: 0 0 20px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #00284e;
}

h2.text-heading {
  margin: 0 0 20px;
  padding: 0;
  color: #00284e;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
}

h3.text-heading {
  margin: 0 0 20px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 20px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #00284e;
}

.text-box {
  position: relative;
  padding: 11.5px 30px;
  border: 1px solid #ac182e;
  border-left: 7px solid #ac182e;
  border-bottom-right-radius: 25px;
  margin-bottom: 27px;
}

p.text-box__text {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 20px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #00284e;
}

span.text-box__emphasis {
  font-weight: 700;
  color: #ac182e;
}

p.round-box-percent__disclaimer {
  margin: 0;
  font-family: Ubuntu;
  font-size: 12px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #555;
}

.round-box.round-box--percent {
  padding: 15px 56px;
  margin-bottom: 29px;
}

.round-box.round-box--percent li.bullet-list__item::before {
  left: 0.4em;
}

.round-box-percent {
  display: flex;
  gap: 15px;
  padding: 0 14.5px;
  margin: 15px auto 30px;
}

p.round-box-percent__heading {
  margin: 0 0 3px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  color: #00284e;
}

img.round-box-percent__graphic {
  align-self: center;
}

p.round-box-percent__text {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: 18px;
  color: #00284e;
}

span.round-box-percent__text--emphasis {
  color: #ac182e;
}

.round-box {
  position: relative;
  padding: 0px 15px 15px 8px;
  border: 1px solid #00284e;
  border-left: 7px solid #00284e;
  border-bottom-right-radius: 25px;
}

h3.round-box__title {
  position: absolute;
  top: -0.6em;
  left: 0;
  margin: 0;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  color: #003865;
  z-index: 1;
}

h3.round-box__title > span {
  display: inline;
  background: #fff;
  padding: 0 10px;
  box-decoration-break: clone;
  /*display: inline-block;*/
}

img.round-box__image {
  max-width: 100%;
  width: 100%;
}

section.efficacy-efs img.round-box__image {
  padding: 25px 0 15px;
}
.round-box.round-box-ovls.left-side-bar img.round-box__image{
	    padding: 0 0 15px;
}
.efficacy-os .perspGrp img.round-box__image {
	padding: 0px 0 15px;
}

img.round-box__image {
  padding-top: 15px;
}
section.efficacy-efs ul.bullet-list.bullet-list--round-box.mb-15{
	margin-bottom:15px;
}
section.efficacy-efs ul.bullet-list.bullet-list--round-box {
  margin-bottom: 30px;
}

section.efficacy-efs h3.text-heading:has(+ .round-box) {
  margin-bottom: 30px;
}

section.efficacy-efs .round-box:has(+ .bullet-list) {
  margin-bottom: 30px;
}

section.efficacy-efs .round-box {
  margin-bottom: 40px;
}

section.efficacy-efs .inner-wrap {
  padding-left: 3px;
}

section.efficacy-efs .inner-wrap .footnotes {
  padding-left: 5px;
  margin-left: -7px;
}
section.efficacy-efs {
  padding-bottom: 50px;
}

section.efficacy-efs .round-box:has(+ .text-heading) {
  margin-bottom: 50px;
}

section.efficacy-efs .round-box:has(+ .round-box) {
  margin-bottom: 29px;
}

section.efficacy-efs .round-box:has(+ .inner-wrap) {
  margin-bottom: 20px;
}

.bullet-list--round-box-percent li.bullet-list__item {
  margin-bottom: 15px;
  padding-left: 27px;
}

p.round-box__disclaimer {
  margin: 15px 0 0 0;
  /*margin: 0 0 0 5px;*/
  padding: 0;
  font-family: Ubuntu;
  font-size: 12px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #555;
}
p.round-box__disclaimer.round-box__disclaimer1 {
    margin-top: -55px;
    margin-bottom: 5px;
}
.round-box.fpo-label::after {
  content: url(/content/dam/website-services/us/434-imfinzi-com/gc-gejc/global/fpo-label.svg);
  top: 50%;
  left: 50%;
  transform: translate(-50%, -50%);
  position: absolute;
  z-index: 2;
}

.section-heading:has(#os) {
  padding-bottom: 30px;
}

section.efficacy-os {
  padding-bottom: 50px;
}

section.efficacy-os .round-box-percent {
  margin-top: 27px;
  margin-bottom: 40px;
}

section.efficacy-os p.round-box-percent__disclaimer {
  margin-bottom: 0;
}

section.efficacy-os .round-box:has(+ .text-heading) {
  padding: 30px 30px 20px 30px;
  margin-bottom: 60px;
}

section.efficacy-os h3.text-heading {
  margin-bottom: 20px;
}

section.efficacy-os .round-box:has(+ .inner-wrap) {
  padding: 30px 16px 8px 16px;
  margin-bottom: 20px;
}

section.efficacy-os .inner-wrap {
  padding-left: 0px;
}

section.efficacy-os .inner-wrap .footnotes {
  /*padding-left: 5px;*/
  width: 736px;
  max-width: 100%;
}

section.efficacy-os ul.bullet-list.bullet-list--round-box {
  margin-bottom: 30px;
}

.round-box.round-box--circles {
  padding: 30px 17.5px 30px;
  margin-bottom: 20px;
  padding-left: 13px;
}
.round-box-circles {
  display: flex;
  gap: 10px;
}

.round-box-circles__circle {
  display: flex;
  align-items: center;
  gap: 0;
}

span.round-box-circles__label {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  color: #000;
  padding-right: 15px;
}

.round-box-circles-wrapper:first-child .round-box-circles__circle {
  /* margin-top: 10px; */
  width: 350px;
  gap: 10px;
}
.round-box-circles-wrapper:first-child
  ul.bullet-list--round-box-circles
  li.bullet-list__item {
  max-width: 280px;
}

.round-box-circles-wrapper:last-child .round-box-circles__circle {
  /* margin-top: 15px; */
  width: 335px;
}
ul.bullet-list.bullet-list--round-box-circles {
  margin-top: 10px;
}

.round-box-circles-wrapper:last-child
  ul.bullet-list--round-box-circles
  li.bullet-list__item {
  max-width: 300px;
}

p.bullet-list__title {
  margin: 0 0 20px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  color: #00284e;
}

ul.bullet-list.bullet-list--text {
  margin-bottom: 20px;
}
section.efficacy-study-design {
  padding-bottom: 0;
}
section.efficacy-study-design div.footnotes {
 /* margin-left: 8px;*/
}

section.efficacy-study-design h3.text-heading {
  margin-bottom: 30px;
}

section.efficacy-sd {
  padding-bottom: 50px;
}

.efficacy .page-switch {
  padding: 40px 0 55px;
}

section.efficacy-sd .round-box.round-box--table {
  padding: 30px 22px 25px;
  margin-bottom: 20px;
}

.section-heading:has(#surgical-data) {
  padding-bottom: 30px;
}

section.efficacy-sd h2.text-heading:has(+ .round-box--circles) {
  margin-bottom: 30px;
}

section.efficacy-sd h3.text-heading:first-of-type {
  margin-bottom: 50px;
  color: #003865;
}

section.efficacy-sd ul.bullet-list.bullet-list--round-box li.bullet-list__item {
  margin-bottom: 20px;
}

section.efficacy-sd
  ul.bullet-list.bullet-list--round-box
  li.bullet-list__item:last-of-type {
  margin-bottom: 30px;
}

section.efficacy-sd .inner-wrap .footnotes {
  width: 736px;
  max-width: 100%;
}

section.efficacy-sd h3.text-heading:has(+ .round-box.round-box--table) {
  color: #003865;
}

a.button {
  display: flex;
  padding: 10.5px 26px;
  justify-content: center;
  align-items: center;
  gap: 10px;
}

a.button.button--primary {
  margin: 0 auto;
  text-align: center;
  font-family: Ubuntu;
  font-size: 21px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  background: #ac182e;
  color: #f0f5fc;
  box-shadow: inset 0 0 0 2px transparent;
}

.button--primary .button__icon {
  width: 16px;
  height: 22px;
  fill: white;
}

section.efficacy-dfs {
  padding-bottom: 50px;
}

section.efficacy-dfs h3.text-heading {
  color: #003865;
}

section.efficacy-dfs ul.bullet-list.bullet-list--round-box {
  margin-bottom: 30px;
}

.section-heading:has(#dfs) {
  padding-bottom: 30px;
}

section.efficacy-dfs h3.text-heading:last-of-type {
  margin-bottom: 30px;
}

.efficacy-dfs .round-box {
  padding: 30px 16px 20px 16px;
  margin-bottom: 20px;
}
.efficacy-dfs p.round-box__disclaimer.round-box__disclaimer1 {
	margin:0;
}
p.msd-ftnt {
  color: #4d4d4f;
  text-align: center;
  /*font-size: 11.13px;
  font-family: Karbon;*/
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  margin: 10px 0 0;
  font-size: 16px;
  font-family: 'Ubuntu';
}
.round-box.round-box-sdpc {
  margin-top: 30px;
}
section.efficacy-dfs li.bullet-list__item:not(:last-of-type) {
  margin-bottom: 8px;
}

section.efficacy-dfs .inner-wrap .footnotes {
 /* margin-left: -5px;*/
}

.section-heading:has(#pcr) {
  padding-bottom: 30px;
}

section.efficacy-pcr {
  padding-bottom: 50px;
}

section.efficacy-pcr h2.text-heading {
  margin-bottom: 30px;
}

section.efficacy-pcr h3.text-heading {
  margin-bottom: 30px;
}

section.efficacy-pcr p.bullet-list__title {
  color: #555;
  margin-bottom: 30px;
}

section.efficacy-pcr li.bullet-list__item {
  margin-bottom: 20px;
}

section.efficacy-pcr li.bullet-list__item ul.bullet-list--sub > li {
  margin-top: 20px;
  margin-bottom: 20px;
}

section.efficacy-study-design a.button.button--primary {
  width: 600px;
  max-width: 100%;
  margin: 50px auto 50px;
}
img.round-box__image.desktop-only.mrgtp {
  padding-top: 40px;
}
section.efficacy-study-design a.button.button--primary .button__text {
  width: 522px;
}

section.efficacy-study-design a.button.button--primary svg.button__icon {
  margin-right: auto;
}

section.efficacy-study-design .text-box {
  margin: 20px auto 30px;
  padding: 30px;
}

section.efficacy-study-design .text-box .text-box__text {
  font-size: 18px;
  font-weight: 700;
  color: #ac182e;
}

section.efficacy-study-design h3.text-heading:has(+ .round-box) {
  color: #003865;
}

a.button.button--primary:hover {
  text-decoration: none;
  color: #ac182e;
  background: #fff;
  box-shadow: inset 0 0 0 2px #ac182e;
}

a.button--primary:hover .button__icon {
  fill: #ac182e;
}

.nccn-box {
  display: flex;
  background: #d9e3f3;
  padding: 25px 23px;
  border-radius: 0px 0px 30px 0px;
  gap: 30px;
  margin: 50px auto 30px;
  align-items: center;
}

img.nccn-box__logo {
  align-self: center;
  margin-bottom: 0.5rem;
}

p.nccn-box__heading {
  margin: 0 0 10px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 22px;
  font-style: normal;
  font-weight: 700;
  line-height: 25px;
  color: #003865;
}

p.nccn-box__text {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 20px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #003865;
}

.nccn-box__content {
  position: relative;
}

.nccn-box__content::after {
  content: "";
  position: absolute;
  top: 2px;
  left: 0;
  height: 98%;
  border-left: 4px solid #003865;
  transform: translateX(-15px);
  z-index: 2;
}

.keypoints-box {
  border-radius: 0 0 25px 0;
  border-top: 7px solid var(--IMFINZI-Global-Red, #ac182e);
  background: rgba(228, 237, 252, 0.5);
}

.keypoints-box {
  border-radius: 0 0 25px 0;
  border-top: 7px solid var(--IMFINZI-Global-Red, #ac182e);
  background: rgba(228, 237, 252, 0.5);
  padding: 30px 0 50px;
  margin: 50px auto 0;
}

h3.keypoints-box__text {
  margin: 0;
  padding: 0;
  color: #ac182e;
  font-family: Ubuntu;
  font-size: 20px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
}

.keypoints-box__title {
  display: flex;
  justify-content: flex-start;
  align-items: center;
  column-gap: 16px;
  margin: 0px 0 23px;
}

.keypoints-box__icon-wrap {
  position: relative;
}

span.keypoints-box__icon-label {
  position: absolute;
  top: 27px;
  left: 120px;
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #fff;
}

p.bullets-list__heading {
  /*margin: 0 83px 10px;*/
  margin: 0 77px 10px 89px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 20px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #555;
}

p.bullets-list__heading em {
  font-weight: 700;
  color: #ac182e;
  font-style: normal;
}

.bullet-list--keypoints-box li.bullet-list__item ul.bullet-list--sub > li {
  margin-bottom: 10px;
}
.bullet-list--keypoints-box li.bullet-list__item ul.bullet-list--sub > li:before{
	content:'';
}
.bullet-list--keypoints-box li.bullet-list__item {
  margin-bottom: 10px;
}

.footnotes.footnotes--keypoints-box {
  padding: 0 85px;
}

p.text-body {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #555;
}

p.text-body:first-of-type {
  margin-top: 20px;
}
p.text-body:not(:last-of-type) {
  margin-bottom: 16px;
}

ul.bullet-list.bullet-list--keypoints-box {
  /*margin: 0 85px 30px;*/
  margin: 0 80px 30px 90px;
  padding: 0;
}

ul.bullet-list {
  margin: 0;
  padding: 0;
  list-style: none;
}

li.bullet-list__item {
  margin: 0;
  padding: 0 0 0 20px;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #555;
  position: relative;
}

.bullet-list__item sup {
  /*font-size: 65%;
  font-feature-settings: "sups" on; */
  font-family: sans-serif;
}

li.bullet-list__item::before {
  /*content: "";
  position: absolute;
  left: 0;
  top: 0.4em;
  width: 6px;
  height: 6px;
  background: url('data:image/svg+xml;utf8,<svg xmlns="http://www.w3.org/2000/svg" width="6" height="6" viewBox="0066" fill="none"><circle cx="3" cy="3" r="3" fill="%23003262"/></svg>')
    no-repeat center;*/
    content: "•";
    color: #555;
    font-size: 1.2em;
    margin-right: 0.5em;
    display: inline-block;
    width: 1em;
    /* width: 6px; */
    /* height: 6px; */
    position: absolute;
    left: 5px;
}

ul.bullet-list--sub li.bullet-list__item::before {
  top: 0.4em;
  width: 12px;
  height: 6px;
  background: url("data:image/svg+xml;utf8,<svg xmlns='http://www.w3.org/2000/svg' width='12' height='6' viewBox='0 0 12 6' fill='none'><line x1='0' y1='2.5' x2='12' y2='2.5' stroke='%23555555' stroke-width='1'/></svg>");
}

div.footnotes {
  display: flex;
  flex-direction: column;
  row-gap: 5px;
  margin: 0;
}
.footnotes__text {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 12px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #555;
}
.footnotes__item {
  position: relative;
  display: flex;
  align-items: flex-start;
  margin: 0;
}
.footnotes__symbol {
  position: absolute;
  top: 0;
  left: -1.3rem;
  width: 1.2rem;
  text-align: right;
  white-space: nowrap;
  line-height: normal;
  font-family: sans-serif;
  font-size: 64%;
  font-feature-settings: "sups" on;
}
.footnotes__symbol.footnote__symbol--ast {
  top: 0;
  font-size: 90% !important;
}

.footnotes__item--def-block .footnotes__symbol {
  visibility: hidden;
}

.page-switch {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 20px 0;
  max-width: 720px;
  margin: 0 auto;
}

a.page-switch__button {
  display: flex;
  align-items: center;
  justify-content: center;
  column-gap: 5px;
  padding: 7px 0;
}

span.page-switch__label {
  margin: 0;
  padding: 0;
  color: 003865;
  text-align: center;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  text-transform: uppercase;
}

.page-switch__button--next .page-switch__icon {
  transform: scaleX(-1);
}

.nccn-left-txt > span.nccn {
  color: #003865;
  text-align: center;
  font-family: Ubuntu;
  font-size: 40.756px;
  font-style: normal;
  font-weight: 700;
  line-height: 15.611px;
}
span.category {
  color: #003865;
  font-family: Ubuntu;
  font-size: 16.885px;
  font-style: normal;
  font-weight: 700;
  line-height: 21.855px;
}
span.preferred {
  color: #003865;
  font-family: Ubuntu;
  font-size: 18.631px;
  font-style: normal;
  font-weight: 700;
  line-height: 21.855px;
}

#efs.sec-link,
#os.sec-link,
#surgical-data.sec-link,
#dfs.sec-link,
#pcr.sec-link,
#study-design.sec-link {
  /*scroll-margin-top: 153px !important;*/
    scroll-margin-top: 190px!important;
}
.mob-break-sm {
  display: none;
}

.efficacy-sd .bullet-list.bullet-list--round-box ul.subul{
	list-style: none;
    padding-left: 20px;
}
li.bullet-list__item.subli::before {
	display:none;
}
li.bullet-list__item p.dash{
	background: #555555;
    width: 12px;
    height: 1px;
    position: absolute;
    top: 9px;
    left: 0px;
}
.round-box__disclaimer.mb-15{
	margin-bottom:15px;
}

/* Global End */

@media screen and (max-width: 991px) {

    #efs.sec-link, #os.sec-link, #surgical-data.sec-link, #dfs.sec-link, #pcr.sec-link, #study-design.sec-link {
		/*scroll-margin-top: 110px !important;*/
        scroll-margin-top: 166px !important;
    }	

  section.page-heading {
    padding: 40px 16px 52px;
  }

  section.page-heading.inner-content {
    border-top: 1px solid #000;
    /*padding-top: 34px;*/
    padding-top:98px;
  }

  .jump-links {
    flex-wrap: wrap;
    justify-content: center;
    margin-bottom: 29px;
    margin-left: 0;
  }
  .round-box-circles {
    flex-direction: column;
    align-items: center;
  }
  .round-box-circles-wrapper:first-child .round-box-circles__circle {
	    width: 330px;
  }

  h1.page-heading__title {
    font-size: 26px;
    line-height: normal;
    font-weight: 500;
    margin-bottom: 19px;
  }
  span.page-heading__emphasis {
    font-size: 26px;
    line-height: normal;
    font-weight: 700;
  }
  p.page-heading__label {
    margin: 0 0 19px;
    font-size: 20px;
  }
  section.page-heading .inner-wrap {
    padding-left: 0;
  }
  h2.jump-links__title {
    margin: 0 0 20px;
  }
  p.jump-links_disclaimer {
    font-size: 10px;
  }
  p.section-head:has(#efs) {
    padding-left: 16px;
  }
  .section-heading {
    padding-bottom: 30px;
  }
  section.efficacy-efs.inner-content {
    padding: 0 16px 50px;
  }
  .text-box {
    padding: 20px;
    margin-bottom: 21px;
  }
  .round-box-percent {
    flex-direction: column;
    padding: 0;
    margin: 12px auto 10px;
  }
  .round-box.round-box--percent {
    padding: 17px 27px 27px 30px;
  }
  h3.round-box__title {
    font-size: 14px;
  }
 .round-box.round-box--table.left-side-bar .round-box__title>span{
	    /*display: inline;*/
  }
  p.round-box-percent__disclaimer {
    font-size: 10px;
    font-weight: 400;
    margin-top: 18px;
    margin-bottom: 0;
  }
  p.round-box__disclaimer {
    font-size: 10px;
    /*margin: 15px 0 15px 30px;*/
    margin: 5px 0 5px 5px;
  }
    p.round-box__disclaimer.round-box__disclaimer1 {
        margin-top: -20px;
    }
  section.efficacy-efs .round-box {
    margin-bottom: 20px;
  }
  section.efficacy-efs h3.text-heading:has(+ .round-box) {
    padding-right: 2px;
  }
  h3.round-box__title.efs-title {
    max-width: 250px;
  }
  .round-box__image-scroll.mobile-only img.round-box__image {
    margin-top: 18px;
  }
  .round-box__image-scroll.mobile-only img.round-box__image.efs-forest-plot-mobile {
		/*height:380px;*/
    width:670px;
  }
  .scroll-indicator__label {
    text-align: center;
    font-size: 14px;
    font-weight: 700;
    color: #808184;
    margin-top: 10px;
    font-family: Ubuntu;
  }
  section.efficacy-efs ul.bullet-list.bullet-list--round-box {
    margin-bottom: 20px;
  }
   section.efficacy-efs ul.bullet-list.bullet-list--round-box.mb-15{
		margin-top:15px;
   }
	.round-box.round-box-ovls.left-side-bar ul.bullet-list.bullet-list--round-box-percent{
		margin-top:15px;
    }
  .footnotes__text {
    font-size: 10px;
    padding-right: 3px;
  }
  .footnotes.footnotes-nccn .section-heading p {
    padding-left: 16px;
  }
  section.efficacy-os.inner-content {
    padding: 0 16px 70px;
  }
  section.efficacy-os.inner-content h2.text-heading {
    margin-bottom: 40px;
  }
  section.efficacy-os .round-box-percent {
    margin-top: 22px;
    margin-bottom: 10px;
  }
  ul.bullet-list.bullet-list--round-box-percent {
    margin-left: -3px;
  }
  .bullet-list--round-box-percent li.bullet-list__item {
    margin-bottom: 10px;
  }
  section.efficacy-os.inner-content p.round-box-percent__disclaimer {
    margin-top: 0;
  }
  section.efficacy-os.inner-content .round-box.round-box--percent {
    padding-bottom: 22px;
    margin-bottom: 32px;
  }
  section.efficacy-os.inner-content
    img.round-box__image.matterhorn-os-1-graph-mob {
    /*width: 100%;*/
    width: 657px;
  }
  .round-box.fpo-label.round-box-ovls span.scroll-icon {
    display: none;
  }
  section.efficacy-os .round-box:has(+ .text-heading) {
    margin-bottom: 26px;
    padding: 0 10px 10px;
  }
  section.efficacy-os.inner-content .text-heading.mb-20 {
    margin-bottom: 20px;
  }
  h3.round-box__title.round-box__title-osresult {
    max-width: 268px;
  }
  ul.bullet-list.bullet-list--round-box.bullet-list--round-box-1 {
    margin-bottom: 20px !important;
  }
  .section-heading:has(#surgical-data) {
    padding-bottom: 30px;
  }
  section.efficacy-sd.inner-content {
    padding: 0 16px 50px;
  }
  section.efficacy-sd.inner-content h2.text-heading {
    margin-bottom: 20px;
  }
  section.efficacy-sd.inner-content .round-box.round-box--circles {
    padding: 15px 16px 10px;
  }

  img.round-box-percent__graphic {
    width: 113px;
  }

  section.efficacy-os img.round-box-percent__graphic {
    width: 123px;
  }

  section.efficacy-study-design a.button.button--primary .button__text {
    width: auto;
    margin-right: auto;
  }
  ul.bullet-list.bullet-list--round-box-circles {
    margin-top: 0;
  }
  .round-box-circles-wrapper:first-child
    ul.bullet-list--round-box-circles
    li.bullet-list__item {
    margin-left: 25px;
    max-width: 288px;
  }
  .round-box-circles-wrapper:last-child .round-box-circles__circle {
    margin-top: 0;
    width: 330px;
  }
  .round-box-circles__circle {
    gap: initial;
  }
  .round-box-circles-wrapper:last-child
    ul.bullet-list--round-box-circles
    li.bullet-list__item {
    max-width: 300px;
    margin-left: 25px;
  }
  .mb-50 {
    margin-bottom: 50px !important;
  }
  section.efficacy-sd .round-box.round-box--table {
    margin-bottom: 33px;
    padding: 30px 22px 27px;
  }
  section.efficacy-sd
    ul.bullet-list.bullet-list--round-box
    li.bullet-list__item:last-of-type {
    margin-bottom: 20px;
  }
  .pl-9 {
    padding-left: 9px;
  }
  section.efficacy-dfs.inner-content {
    padding: 0px 16px 50px;
  }
  section.efficacy-dfs.inner-content h2.text-heading,
  section.efficacy-dfs.inner-content h3.text-heading {
    margin-bottom: 40px;
  }
  .efficacy-dfs .round-box {
    margin-top: -14px;
    margin-bottom: 40px;
  }
  section.efficacy-dfs li.bullet-list__item:not(:last-of-type) {
    margin-bottom: 20px;
  }
  section.efficacy-dfs ul.bullet-list.bullet-list--round-box {
    margin-bottom: 50px;
  }
  section.efficacy-dfs .inner-wrap .footnotes {
    margin-left: 12px;
  }
  .section-heading:has(#pcr) {
    padding-bottom: 30px;
  }
  section.efficacy-pcr.inner-content {
    padding: 0 16px 50px;
  }
  section.efficacy-pcr h2.text-heading {
    margin-bottom: 20px;
  }
  section.efficacy-pcr h3.text-heading {
    margin-bottom: 20px;
  }
  section.efficacy-pcr p.bullet-list__title {
    margin-bottom: 20px;
  }
  section.efficacy-pcr.inner-content .inner-wrap .footnotes {
    margin-left: 11px;
  }
  .section-heading-sdpc .section-head {
    max-width: 222px;
    padding: 0;
    display: flex;
    margin-left: 16px;
  }
  .section-heading-sdpc .section-head span {
    padding: 10px;
  }
  section.efficacy-study-design.inner-content {
    padding: 0 16px 0;
  }
  section.efficacy-study-design.inner-content h2.text-heading{
		 margin-bottom: 40px;
	}
  section.efficacy-study-design.inner-content h3.text-heading {
    margin-bottom: 50px;
  }
  .section-heading.section-heading-sdpc {
    padding-bottom: 30px;
  }
  section.efficacy-study-design.inner-content .round-box {
    margin-top: -24px;
    padding-bottom: 2px;
  }
  section.efficacy-study-design.round-box-sdpc img.round-box__image {
    margin: 0;
  }

.round-box{
	    padding: 0px 15px 27px 8px;
 }
  p.msd-ftnt {
    padding: 10px 0 20px;
    text-align: left;
  }
  section.efficacy-study-design.inner-content .round-box.rb-2 {
    margin-top: -10px;
  }
  .ml-0 {
    margin-left: 0 !important;
  }
  section.efficacy-study-design .text-box {
    margin: 34px auto 50px;
  }
  section.efficacy-study-design .text-box {
    margin: 34px auto 50px;
    padding: 30px;
  }
  section.efficacy-study-design.inner-content .footnotes {
    margin-left: 11px;
  }

  p.section-head {
    padding-left: 16px;
  }

  .nccn-box {
    padding: 10px 22px 40px;
    border-radius: 0;
    margin-bottom: 0;
    align-items: center;
    padding-top: 20px;
    border-radius: 0px 0px 30px 0px;
  }

  .nccn-left-txt > span.nccn {
    font-size: 34px;
  }

  .nccn-box__content::after {
    border-left: 2px solid #003865;
  }

  span.category {
    font-size: 15px;
    font-style: normal;
    font-weight: 700;
    line-height: 14px; /* 93.333% */
    text-transform: uppercase;
  }
  span.preferred {
    font-size: 15px;
    font-style: normal;
    font-weight: 700;
    line-height: 14px; /* 93.333% */
    text-transform: uppercase;
  }
  p.nccn-box__heading,
  p.nccn-box__text {
    font-size: 14px;
    line-height: 16px;
  }
  p.nccn-box__text {
    width: 194px;
  }

  img.nccn-box__logo {
    width: 90px;
  }
  .footnotes.footnotes-nccn {
   /* background: #d9e3f3;
    margin-left: 0 !important;*/
    margin: 0 10px 0 -10px !important;
    padding: 34px 0 0 11px;
    border-bottom-right-radius: 30px;
    row-gap: 0;
  }
  section.efficacy-study-design.inner-content .footnotes-nccn p.footnotes__text{
	font-size:12px;
    margin-bottom:5px;
	}
  .footnotes__symbol {
    font-size: 52% !important;
  }
  section.efficacy-efs.inner-content
    .footnotes__item.footnotes__item--def-block
    p.footnotes__text {
    margin-top: 5px;
  }
  section.efficacy-efs .inner-wrap .footnotes {
    row-gap: 1px;
  }
  .footnotes__item.footnotes__item--def-block p.footnotes__text {
    margin-top: 29px;
  }
  .keypoints-box__title {
    flex-direction: column;
    align-items: flex-start;
  }
  h3.keypoints-box__text {
    margin-left: 25px;
    margin-top: 23px;
    font-weight: 700;
  }
  p.bullets-list__heading {
    margin: 0 25px 10px 25px;
  }
  ul.bullet-list.bullet-list--keypoints-box {
    margin: 0px 25px 10px 25px;
  }
  .bullet-list--keypoints-box li.bullet-list__item:last-child {
    margin-bottom: 40px;
  }
  .footnotes.footnotes--keypoints-box {
    padding: 0 30px 0 7px;
  }
  .footnotes.footnotes--keypoints-box
    .footnotes__item.footnotes__item--def-block
    p.footnotes__text {
    margin-top: 5px;
  }
  .keypoints-box {
    border-radius: 0;
    padding-bottom: 20px;
    padding-top:20px;
  }
  section.efficacy-study-design a.button.button--primary {
    margin: 40px auto 30px;
    padding: 17px 24px;
    width: 100%;
  }

  section.efficacy-efs .round-box:has(+ .round-box) {
    margin-bottom: 29px;
  }

  section.efficacy-efs .round-box:has(+ .text-heading) {
    margin-bottom: 20px;
  }

  section.efficacy-efs h3.text-heading:has(+ .round-box) {
    margin-bottom: 20px;
    padding: 0px 15px 27px 8px;
  }
  .section-heading:has(#os) {
    padding-bottom: 30px;
  }
  section.efficacy-os .text-box:has(+ .round-box.round-box--percent) {
    margin-bottom: 26px;
  }

  section.efficacy-sd
    .footnotes__item.footnotes__item--def-block
    p.footnotes__text {
    margin-top: 0;
  }

  section.efficacy-dfs
    .footnotes__item.footnotes__item--def-block
    p.footnotes__text {
    margin-top: 0;
  }

  section.efficacy-os
    .footnotes__item.footnotes__item--def-block
    p.footnotes__text {
    margin-top: 0;
  }

  .button--primary .button__icon {
    width: 14px;
    height: 25px;
    flex-shrink: 0;
  }

  section.efficacy-study-design a.button.button--primary svg.button__icon {
    margin-left: auto;
    margin-right: 0;
  }

  use.icon--desktop {
    display: none;
  }
  use.icon--mobile {
    display: inline;
  }
  .efficacy .page-switch {
    padding: 37px 37px 10px;
  }
  .mt-0 {
    margin-top: 0 !important;
  }
  .mb-0 {
    margin-bottom: 0 !important;
  }
	.section-heading span {
		padding: 10px 10px;
    }
  .efficacy-efs.inner-content{
		position: relative;
    }
	 .round-box--percent:before {
        content: "";
        width: 7px;
        height: calc(100% + 124px);
    	height: 30px;
        display: inline-block;
        background: #003262;
        position: absolute;
        top: 597px;
        top: -7px;
        left: -7px;
    }
	.left-side-bar:before {
        content: "";
        width: 7px;
        height: calc(100% + 124px);
    	height: 30px;
        display: inline-block;
        background: #003262;
        position: absolute;
        top: 597px;
        top: -7px;
        left: -7px;
    }
	.keypoints-box__icon-wrap .keypoints-box__icon.mobile-only{
		width:100%;
    }
	.efs-forest-plot-mobile-scroll span.scroll-icon {
		top: 33%;
    }
	.round-box__image-scroll.mobile-only.efs-forest-plot-mobile-scroll .round-box__image{
		height: 390px;
    }
	.round-box.left-side-bar.perspGrp .round-box__image{
		height: 360px;
    }
	.round-box.left-side-bar.perspGrp span.scroll-icon{
		top:33%;
    }
	.round-box.round-box-ovls.left-side-bar img.round-box__image {
		padding: 25px 0 0px;
    }
	.round-box.round-box-sdpc.left-side-bar .round-box__image{
		width: 690px;
    }
	.round-box.round-box-sdpc.left-side-bar .scroll-icon{
		top: 33%;
     }

    .NCCN-layout-wrap--new.efficacy--nccn {
        margin-bottom: 0;
    }

    .NCCN-layout-wrap--new.efficacy--nccn + .footnotes.footnotes-nccn .footnotes__item.footnotes__item--def-block p.footnotes__text {
        margin-top: 1px;
    }
    
    .NCCN-layout-wrap--new.efficacy--nccn + .footnotes.footnotes-nccn {
        padding-top: 25px;
    }

    section.efficacy-efs .round-box:has(+ .round-box) {
        padding-bottom: 22px;
    }
    
    section.efficacy-efs .round-box:has(+ .text-heading),
    section.efficacy-efs .round-box:has(+ .inner-wrap) {
        padding-bottom: 17px;
    }

}

/* Desktop only */
@media (min-width: 992px) {
  use.icon--mobile {
    display: none;
  }

    .efficacy .keypoints-box span.keypoints-box__icon-label {
        left: 101px;
    }
    
    .efficacy .keypoints-box ul.bullet-list.bullet-list--sub {
        margin-top: 10px;
    }
    
    .efficacy-efs  .text-box,
    .efficacy-os .text-box {
        padding-left: 23px;
    }
	.efficacy-efs.inner-content{
		position: relative;
    }
	 .round-box--percent:before {
        content: "";
        width: 7px;
        height: calc(100% + 124px);
    	height: 30px;
        display: inline-block;
        background: #003262;
        position: absolute;
        top: 597px;
        top: -7px;
        left: -7px;
    }
	.left-side-bar:before {
        content: "";
        width: 7px;
        height: calc(100% + 124px);
    	height: 30px;
        display: inline-block;
        background: #003262;
        position: absolute;
        top: 597px;
        top: -7px;
        left: -7px;
    }
}
section.efficacy-study-design div.footnotes-nccn {
    margin-left: 8px;
    letter-spacing: -0.1px;
    /*margin-left: 10px;*/
    margin-left:0;
}

.efficacy section.efficacy-sd h3.text-heading.surgical--text,
.efficacy h3.text-heading.text-heading--new{
    margin-bottom: 30px;
}
/* Desktop only END */


  /* CSS specific to iOS devices */ 
@supports (-webkit-touch-callout: none) {
    h3.round-box__title > span {
		display: inline-block;
    }
}

@media screen and (max-width: 369px) {
	span.round-box-circles__label {
        padding-right: 0;
    }
    
    .round-box-circles__circle > img {
        width: 115px;
    }
    
    .round-box-circles-wrapper .round-box-circles__circle {
        width: 100%;
    }
    
    .round-box-circles__circle {}
    
    .round-box-circles-wrapper:first-child .round-box-circles__circle,
    .round-box-circles-wrapper:last-child .round-box-circles__circle{
        width: 100%;
    }
    
    .round-box-circles-wrapper:last-child .round-box-circles__circle {
        gap: 10px;
    }

}

@media screen and (min-width: 700px) and (max-width: 991px) {
	.round-box__image-scroll.mobile-only.efs-forest-plot-mobile-scroll .round-box__image, .round-box.left-side-bar.perspGrp .round-box__image {
        margin-inline: auto;
    }

}