/* -- Safety New CSS -- */

/* Global */

.main-container {
  margin: 0 auto;
  max-width: 950px;
  background: #fff;
}

section.page-heading {
  padding: 40px 0 55px;
}

section.inner-content {
  max-width: 720px;
  margin: 0 auto;
}

p.page-heading__label {
  /*margin: 52px 0 10px;*/
  margin: 88px 0 10px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #003865;
}

h1.page-heading__title {
  margin: 0 0 30px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 38px;
  font-style: normal;
  font-weight: 700;
  line-height: 48px;
  color: #003865;
}

span.page-heading__emphasis {
  font-size: 48px;
  line-height: 48px;
}

h2.page-heading__links {
  margin: 0 0 10px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #003865;
}

a.page-heading__link {
  display: block;
  width: fit-content;
  margin: 0 0 10px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 21px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  text-align: left;
  color: #7098d2;
  text-decoration-line: underline;
  text-decoration-style: solid;
  text-decoration-thickness: auto;
  text-decoration-skip-ink: none;
  text-underline-offset: auto;
  text-underline-position: from-font;
}

a.page-heading__link:last-of-type {
  margin-bottom: 0;
}

a.page-heading__link:hover {
  text-decoration: none;
}

p.page-heading__disclaimer {
    margin: 0 0 20px;
    padding: 0;
    font-family: Ubuntu;
    font-size: 20px;
    font-style: normal;
    font-weight: 500;
    line-height: normal;
    color: #555;
}

a.page-heading__disclaimer-link {
  font-family: Ubuntu;
  font-size: 20px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  text-decoration-line: underline;
  text-decoration-style: solid;
  text-decoration-skip-ink: none;
  text-decoration-thickness: auto;
  text-underline-offset: auto;
  text-underline-position: from-font;
  color: #003865;
}

a.page-heading__disclaimer-link:hover {
  text-decoration: none;
}

.section-heading {
  background: #fff;
  border-top: 1px solid #00284e;
  padding-bottom: 20px;
}

.section-heading p {
  margin: 0;
  padding: 10px 0 10px 110px;
  border-bottom-left-radius: 16px;
  border-bottom-right-radius: 16px;
}

.section-heading span {
  padding: 10px 20px;
  border-bottom-left-radius: 16px;
  border-bottom-right-radius: 16px;
  font-family: Ubuntu;
  font-size: 18px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  color: #fff;
  background: #ac182e;
}

p.text-eyebrow {
  margin: 0 0 20px;
  padding: 0;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #003262;
}

h2.text-heading {
  margin: 0 0 20px;
  padding: 0;
  color: #003865;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
}

.round-box {
  position: relative;
  padding: 0 10px 25px 15px;
  border: 1px solid #00284e;
  border-left: 7px solid #00284e;
  border-bottom-right-radius: 25px;
}

h3.round-box__title {
  position: absolute;
  top: -0.6em;
  left: 0;
  margin: 0;
  font-family: Ubuntu;
  font-size: 14px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  text-transform: uppercase;
  color: #00284e;
  z-index: 1;
}

h3.round-box__title > span {
  display: inline;
  background: #fff;
  padding: 0 10px;
  box-decoration-break: clone;
}

.round-box--rates h3.round-box__title > span {
  color: #003865;
  display: inline-block;
}

img.round-box__image {
  padding-top: 40px;
  max-width: 100%;
  width: 100%;
}

section.safety-adr.inner-content {
  margin-bottom: 65px;
}

section.safety-adr .round-box {
  margin-bottom: 30px;
}

section.safety-adr ul.bullet-list {
  margin-bottom: 20px;
}

section.safety-adr .footnotes {
  max-width: 710px;
}

section.safety-adr .footnotes__item.footnotes__item--def-block {
  max-width: 690px;
}

ul.bullet-list {
  margin: 0;
  padding: 0;
  list-style: none;
}

li.bullet-list__item {
  margin: 0;
  padding: 0 0 0 20px;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #555;
  position: relative;
}

.bullet-list__item sup {
  font-size: 65%;
  font-feature-settings: "sups" on;
  font-family: sans-serif;
}

li.bullet-list__item:not(:last-child) {
  margin-bottom: 20px;
}

li.bullet-list__item::before {
  /*content: "";
  position: absolute;
  left: 0;
  top: 0.4em;
  width: 6px;
  height: 6px;
  background: url('data:image/svg+xml;utf8,<svg xmlns="http://www.w3.org/2000/svg" width="6" height="6" viewBox="0066" fill="none"><circle cx="3" cy="3" r="3" fill="%23003262"/></svg>')
    no-repeat center;*/
    content: "•";
    color: #555;
    font-size: 1.2em;
    margin-right: 0.5em;
    display: inline-block;
    width: 1em;
    position: absolute;
    left: 5px;
    top:-2px;
}

p.text-highlight {
  margin: 0 0 30px;
  padding: 0;
  color: #003865;
  font-family: Ubuntu;
  font-size: 20px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
}

div.footnotes {
  display: flex;
  flex-direction: column;
  row-gap: 5px;
  margin: 0;
}
.footnotes__text {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 12px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  color: #555;
}
.footnotes__item {
  position: relative;
  display: flex;
  align-items: flex-start;
  margin: 0;
}
.footnotes__symbol {
  position: absolute;
  top: 0;
  left: -1.3rem;
  width: 1.2rem;
  text-align: right;
  white-space: nowrap;
  line-height: normal;
  font-family: sans-serif;
  font-size: 64%;
  font-feature-settings: "sups" on;
}
.footnotes__symbol.footnote__symbol--ast {
  top: 0;
  font-size: 90%;
}

.footnotes__item--def-block .footnotes__symbol {
  visibility: hidden;
}

.section-heading:has(#discontinuation-rates) {
  padding-bottom: 40px;
}

span.text-highlight__emphasis {
  font-weight: 700;
  color: #ac182e;
}

.round-box.round-box--rates {
  padding: 30px 0 30px 30px;
  border-bottom-right-radius: 15px;
  border-left: 7px solid #003865;
}

.round-box-rates {
  display: flex;
  gap: 10px;
  justify-content: flex-start;
  align-items: center;
}

span.round-box-rates__value {
  margin: 0;
  padding: 0;
  color: #ad1f2f;
  font-family: Ubuntu;
  font-size: 42px;
  font-style: normal;
  font-weight: 700;
  line-height: 22px;
}

.round-box-rates__value sup {
  top: -0.6em;
  font-size: 60%;
}

p.round-box-rates__label {
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  color: #555;
}

section.safety-dir.inner-content {
  margin-bottom: 65px;
}

section.safety-dir .round-box.round-box--rates {
  margin-bottom: 20px;
  margin-top: 38px;
}

section.safety-dir ul.bullet-list {
  margin-bottom: 20px;
}

section.safety-dir div.footnotes {
  margin-top: 30px;
}

.section-heading:has(#laboratory-abnormalities) {
  padding-bottom: 40px;
}

section.safety-lab.inner-content {
  padding-bottom: 50px;
}

section.safety-lab h2.text-heading {
  margin-bottom: 25px;
  color: #003262;
}

section.safety-dir h2.text-heading {
  color: #003262;
}

section.safety-lab img.round-box__image {
  padding-top: 20px;
}

section.safety-lab .round-box {
  padding: 0 14px 20px 18px;
  margin-bottom: 6px;
}

.footnotes.footnotes--roundbox {
  margin-bottom: 5px;
}

section.safety-lab ul.bullet-list:not(:last-child) {
  margin-bottom: 30px;
}
section.safety-lab .footnotes__item.footnotes__item--def-block {
  margin-bottom: 50px;
}

.keypoints-box {
  border-radius: 0 0 25px 0;
  border-top: 7px solid var(--IMFINZI-Global-Red, #ac182e);
  background: rgba(228, 237, 252, 0.5);
}

.keypoints-box {
  border-radius: 0 0 25px 0;
  border-top: 7px solid var(--IMFINZI-Global-Red, #ac182e);
  background: rgba(228, 237, 252, 0.5);
  padding: 30px 0 50px;
}

h3.keypoints-box__text {
  margin: 0;
  padding: 0;
  color: #ac182e;
  font-family: Ubuntu;
  font-size: 20px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
}

.keypoints-box__title {
  display: flex;
  justify-content: flex-start;
  align-items: center;
  column-gap: 16px;
  margin: 0 0 18px;
}

.keypoints-box__icon-wrap {
  position: relative;
}
span.keypoints-box__icon-label {
  position: absolute;
  top: 27px;
  left: 120px;
  margin: 0;
  padding: 0;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  color: #fff;
}

ul.bullet-list.bullet-list--keypoints-box {
  margin: 0 85px;
  padding: 0;
}

.page-switch {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 20px 0;
  max-width: 720px;
  margin: 0 auto;
}

a.page-switch__button {
  display: flex;
  align-items: center;
  justify-content: center;
  column-gap: 5px;
  padding: 7px 0;
}

span.page-switch__label {
  margin: 0;
  padding: 0;
  color: 003865;
  text-align: center;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  text-transform: uppercase;
}

.page-switch__button--next .page-switch__icon {
  transform: scaleX(-1);
}

#adverse-reactions,
#discontinuation-rates,
#laboratory-abnormalities {
  	/*scroll-margin-top: 153px !important;*/
    scroll-margin-top: 190px !important;
}

.mob-break-sm {
  display: none;
}

.safety-adr.inner-content {
  position: relative;
}
.left-side-bar:before {
  content: "";
  width: 7px;
  height: calc(100% + 124px);
  height: 30px;
  display: inline-block;
  background: #003262;
  position: absolute;
  top: 597px;
  top: -7px;
  left: -7px;
}

.safety ul.sub-bullet--list {
    list-style-type: none;
    padding-left: 25px;
    padding-top: 9px;
}

.safety ul.sub-bullet--list > li {
    position: relative;
}

.safety ul.sub-bullet--list > li:before {
    content: "–";
    font-family: 'font-awesome';
    font-size: 13px;
    top: -3px;
    line-height: 19px;
    position: absolute;
    left: -16px;
}

/* Global end */

/* Desktop only */

@media (min-width: 992px) {
  section.safety-lab div.footnotes:last-child,
  section.safety-dir div.footnotes {
    width: 102%;
  }
  section.safety-adr h2.text-heading {
    margin-bottom: 25px;
  }
	span.keypoints-box__icon-label {
		left: 101px;
	}
}

/* Desktop only End*/

/* Mobile */

@media screen and (max-width: 991px) {
  .maincontent.parsys {
    border-top: 1px solid #000;
  }
  .main-container {
    padding: 0 15px;
  }

  section.page-heading {
    /*padding: 30px 0 40px;*/
    padding: 94px 0 40px;
  }
  p.page-heading__label {
    font-size: 20px;
    margin-bottom: 20px;
    margin-top: 0;
  }

  h1.page-heading__title {
    font-size: 24px;
    line-height: normal;
    margin-bottom: 20px;
  }

  span.page-heading__emphasis {
    font-size: 26px;
    line-height: normal;
  }

  p.section-head {
    padding-left: 15px;
  }

  .section-heading span {
    padding: 10px;
  }

  h3.round-box__title {
    top: -1.1em;
  }

  h3.round-box__title > span {
    padding: 0 10px;
  }

  section.safety-lab h3.round-box__title > span {
    display: inline-block;
    width: 276px;
    padding: 0 17px;
  }
  .section-heading:has(#adverse-reactions) {
    padding-bottom: 40px;
  }

  section.safety-adr h2.text-heading {
    margin-bottom: 46px;
  }

  section.safety-dir.inner-content {
    padding-left: 3px;
    padding-right: 3px;
  }

  section.safety-dir.inner-content {
    margin-bottom: 50px;
  }

  div.footnotes {
    margin-left: 0.2rem;
  }
  .footnotes__text {
    line-height: normal;
    margin: 0 0 6px;
  }
  .footnotes__text sup {
    top: -0.4em;
    font-size: 70%;
  }
  .footnotes__item.footnotes__item--def-block .footnotes__text {
    margin-bottom: 0;
  }

  .round-box {
    padding: 10px 0 10px 10px;
  }

  .round-box__image-scroll.mobile-only {
    overflow-x: auto;
    width: 100%;
    max-width: 100%;
    -webkit-overflow-scrolling: touch;
  }

  .round-box__image-scroll .round-box__image {
    display: block;
    height: auto;
    width: auto;
    max-width: none;
  }

  section.safety-adr img.round-box__image {
    padding-top: 36px;
    width: 627px;
  }

  section.safety-adr .scroll-indicator {
    margin-top: 45px;
  }

  section.safety-adr .round-box {
    padding-bottom: 17px;
  }

  section.safety-adr ul.bullet-list {
    padding-left: 3px;
    padding-right: 3px;
    margin-bottom: 20px;
  }

  section.safety-adr p.text-highlight {
    margin-bottom: 20px;
  }

  section.safety-adr .footnotes {
    padding-left: 3px;
    padding-right: 3px;
    margin-left: 0.6em !important;
  }

  section.safety-adr.inner-content {
    margin-bottom: 50px;
  }

  .section-heading:has(#discontinuation-rates) {
    padding-bottom: 30px;
  }

  section.safety-dir h2.text-heading {
    margin-bottom: 40px;
  }

  section.safety-dir p.text-highlight {
    margin-bottom: 38px;
    padding-left: 3px;
    padding-right: 3px;
  }

  section.safety-dir .round-box.round-box--rates {
    padding: 30px;
  }

  section.safety-dir div.footnotes {
    margin-top: 20px;
    margin-left: 0.6em;
  }

  .section-heading:has(#laboratory-abnormalities) {
    padding-bottom: 30px;
  }

  section.safety-lab.inner-content {
    padding-left: 3px;
    padding-right: 3px;
    padding-bottom: 40px;
  }
  .section.safety-lab.inner-content .round-box__title > span {
    width: auto;
    padding: 0 0 0 10px;
  }
  section.safety-lab h2.text-heading {
    margin-bottom: 26px;
  }

  section.safety-lab .round-box {
    padding: 10px 0 6px 10px;
    margin-bottom: 29px;
  }

  section.safety-lab img.round-box__image {
    padding-top: 35px;
  }

  section.safety-lab .round-box__image-scroll .round-box__image {
    height: 630px;
    width: 722px;
  }

  section.safety-lab .footnotes.footnotes--roundbox {
    margin-left: 0.6em;
    margin-bottom: 5px;
  }

  section.safety-lab .footnotes__item.footnotes__item--def-block {
    margin-bottom: 60px;
  }

  .keypoints-box {
    padding: 20px 0 20px;
  }

  h3.keypoints-box__text {
    align-self: flex-start;
    margin-left: 40px;
  }
  ul.bullet-list.bullet-list--keypoints-box {
    margin: 0 40px;
  }

  span.keypoints-box__icon-label {
    /*left: 100px;*/
  }

  .keypoints-box__title {
    flex-direction: column;
    row-gap: 23px;
    column-gap: 0;
    margin-bottom: 20px;
  }
  .keypoints-box .keypoints-box__icon{
		width:100%;
   }
  .footnotes__text {
    font-size: 10px;
    margin-bottom: 0;
  }

  .scroll-indicator {
    display: flex;
    flex-direction: column;
    align-items: center;
    margin-top: 15px;
  }

  .scroll-indicator__track {
    position: relative;
    width: 100%;
    max-width: 300px;
    height: 12px;
    background-color: #f4f4f4;
    border: 1px solid #808184;
    overflow: hidden;
  }

  .scroll-indicator__fill {
    position: absolute;
    top: 0;
    left: 0;
    height: 100%;
    width: 120px;
    background-color: #808184;
    transition: transform 80ms linear;
    will-change: transform;
  }

  .scroll-indicator__label {
    margin-top: 6px;
    font-family: Ubuntu;
    font-size: 14px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    text-transform: uppercase;
    color: #808184;
  }

  span.scroll-icon {
    content: url(/content/dam/website-services/us/434-imfinzi-com/gc-gejc/mobile/scroll-icon.svg);
    position: absolute;
    top: 50%;
    left: 50%;
    width: auto;
    height: auto;
    z-index: 2;
    transform: translate(-50%, -50%);
  }

  a.page-switch__button {
    padding: 7px 22px;
  }
  #adverse-reactions,
  #discontinuation-rates,
  #laboratory-abnormalities {
    /*scroll-margin-top: 110px !important;*/
    scroll-margin-top: 166px !important;
  }
  .safety-adr.inner-content {
    position: relative;
  }
  .left-side-bar:before {
    content: "";
    width: 7px;
    height: calc(100% + 124px);
    height: 30px;
    display: inline-block;
    background: #003262;
    position: absolute;
    top: 597px;
    top: -7px;
    left: -7px;
  }
  .left-side-bar.box1:before {
    top: -18px;
    left: -6.4px;
  }
  .left-side-bar.box2:before {
    top: -12px;
  }
	.footnotes__symbol {
      position: absolute;
      /*top: 0;
      left: -1.3rem;
      width: 1.2rem;
      font-size: 64%;*/
      top: -2px;
      left: -1rem;
      width: 1rem;
      font-size: 50%;
      text-align: right;
      white-space: nowrap;
      line-height: normal;
      font-family: sans-serif;
      font-feature-settings: "sups" on;
    }
	.safety-lab .footnotes__item--def-block{
	  margin-left: 7px;
    }
}

/* Mobile End */

/* 390px Breaks Only */

@media screen and (max-width: 390px) {
  .mob-break-sm {
    display: block;
  }
}

/* 390px Breaks Only End*/

@media screen and (max-width: 370px) {
	span.keypoints-box__icon-label {
        top: 50%;
        transform: translateY(-50%);
        left: 32%;
    }
}

@media screen and (min-width: 768px) and (max-width: 991px) {
   section.inner-content {
        max-width: 100%;
    }
    
    .main-container {
        max-width: 100%;
    }
    
    .page-switch.inner-content {
        max-width: 100%;
    }

    .keypoints-box__title {
        flex-direction: row;
    }
    
    h3.keypoints-box__text {
        align-self: center;
        margin-left: 20px;
    }

    section.safety-adr img.round-box__image.desktop-only,
    .safety section.safety-lab img.round-box__image {
        margin-inline: auto;
    }

}