.flex{
        display: flex;
        max-width: 610px;
        justify-content: center;
        align-items: center;
}
.page-content{
        margin-top: 30px
}
.os-mutation-status-sec .section-heading{
            display: none;
}
.list-sec{
        margin: 30px auto;
}
ul.arrow-list{
        padding-right: 0;
}
.box-image{
        max-width: 694px;
}
p.box-heading{
        padding: 0 10px 0 30px;
}
.box-image.box-light-blue{
        margin: 40px 10px 0px 22px;
        padding: 25px 15px 15px 20px !important;
}
.box-image p{
        color: #003262;
}
.box-image .flex p{
        color: #003262;
        font-weight: 500;
        font-size: 16px;
        line-height: 20px;
        margin-left: -10px;
}
.box-image>div.flex>div:nth-child(2) p{
        color: #7B7B7B;
}
.genomic-alterations-sec{
        margin-bottom: 30px;
}
.box-image.box-light-blue.prevalence-box img{
        margin: 20px 0 15px -8px;
}
#os-mutation-status {
    margin-top: 0px;
}
#os-mutation-status h2{
        padding-bottom: 0;
        margin-bottom: 0;
}
#os-mutation-status .box-image img{
        /* margin: 23px 0 32px -13px; */
        margin: 23px 0 32px -10px;
}
#os-mutation-status .footnotes{
        color: #4a4a4a;
        margin-bottom: 5px;
}
#os-mutation-status .box-image.box-light-blue{
        padding: 25px 15px 25px 20px !important;
        margin-bottom: 40px;
}
#os-mutation-status{
        margin-bottom: 57px;
}
.patient-reported-outcomes-sec p.eyebrow {
    font-size: 16px;
    line-height: 25px;
}
.patient-reported-outcomes-sec .page-content h2{
        margin-bottom: 20px;
}
.patient-reported-outcomes-sec .sub-head-topaz{
        padding-bottom: 0;
        margin-bottom: 0;
}
.patient-reported-outcomes-sec ul.arrow-list.hypen-list{
    margin-top: 20px;
    margin-bottom: 10px;
}
.patient-reported-outcomes-sec ul.hypen-list {
    padding-left: 10px !important;
}
.patient-reported-outcomes-sec .hypen-list li:before {
    content: '–' !important;
    left: -10px !important;
}
.patient-reported-outcomes-sec ul.arrow-list.hypen-list li{
        margin-bottom: 6px;
}
.patient-reported-outcomes-sec .list-sec{
        margin-bottom: 55px;
        margin-top: 15px;
}
.time-chart-1 {
        /* margin-left:0; */
        /* margin-right: 0; */
}
.time-chart-1 img{
        margin: 28px 0 26px -15px;
    	padding: 0 10px;
}
.time-chart-1 .footnotes{
        margin-bottom: 20px;
}
.time-chart-2 img{
        margin: 27px 0 20px -10px;
}
.box-image.time-chart-2 {
    margin-top: 60px;
}
.box-image.box-light-blue img {
        margin-top: -5px;
    }
    .additional-analyses .section-heading span {
        padding: 7px 14px;
        position: relative;
        top: 1px;
    }
.box-image.box-light-blue .flex img {
    max-width: 138px;
}

@media screen and (max-width: 767px){

 .additional-analyses    p.footnotes.special-indent {
    text-indent: 1px;
    margin-left: 1px;
}

    .additional-analyses .section-heading span {
        padding: 7px 14px;
        position: relative;
        top: 1px;
    }
        .page-content{
                margin-top: 15px;
        }
        .btc-hcp .page-content h2{
                padding: 6px 0 0px;
        }
        .list-sec{
                margin: 25px 0 0px;
        }

        ul.arrow-list{
                padding-left: 32px;
        }
        .ls-1 {
            letter-spacing: -0.1px !important;
        }
        .ls-2 {
            letter-spacing: -0.2px !important;
        }
        .ls-3 {
            letter-spacing: -0.3px !important;
        }
        .arrow-list li:before{
              left: -32px;
        }
        .additional-analyses .page-content p.eyebrow {
            margin-top: 14px;
        }
        .genomic-alterations-sec .box-image.box-light-blue{
                margin: 35px 0px 30px 5px;
                padding: 20px 15px 10px 20px!important;
        }
        .btc-hcp p.box-heading{
                width: 240px;
                /* margin-top: -34px; */
                margin-bottom: 15px;
        }
        .genomic-alterations-sec .page-content h2 {
            margin-top: 22px;
        }
        .genomic-alterations-sec .box-image.box-light-blue>div.flex{
                flex-direction: column;
        }
        .genomic-alterations-sec .box-image.box-light-blue.prevalence-box{
                margin: 40px 0px 30px 5px;
        }
        .genomic-alterations-sec .list-sec {
            margin-top: 30px;
        }
        .genomic-alterations-sec .prevalence-box p.box-heading{
                width: 260px;
                margin-top: -29px;
                margin-top: -29px;
                font-size: 14px;
                line-height: 16px;
        }
        p.box-heading.box-heading-explo-os {
            font-size: 14px;
            line-height: 16px;
            width: 233px;
            margin-top: -34px;
        }
        p.box-heading.box-heading-biomaker {
            width: 200px;
            font-size: 14px;
            line-height: 16px;
        }
        p.footnotes{
                font-size: 12px;
                line-height: 14px!important;
        }
        .genomic-alterations-sec .footnotes{
                margin-top: 25px;
        }

        #os-mutation-status .box-image.box-light-blue {
            margin: 30px 0 30px 5px;
        }
        #os-mutation-status .footnotes {
            /*margin-bottom: 0;*/
        }
        p.footnotes.ftnt-aa1 {
            margin: 25px 0 0;
            letter-spacing: -0.1px;
        }
        ul.hypen-list {
            padding-left: 13px !important;
        }
        .hypen-list li:before {
            left: -13px !important;
        }
        .box-image.time-chart-1 {
            margin-top: -30px !important;
        }
        .time-chart-1 img {
            margin: 15px 0 26px -8px;
            max-width: 104% !important;
        }
        .box-image.time-chart-2{
            margin-bottom: 10px !important;
        }
        .flex.margin-biomaker-per {
            margin: -5px auto;
        }
    }