/* Additional Studies Page CSS */

.additional-studies .section-heading span {
  padding: 6px 18px;
}

.additional-studies .section-heading h2 {
  max-width: 750px;
}

.additional-studies .page-content {
  max-width: 750px;
  margin: 0 auto;
  padding: 0 18px 0 20px;
  box-sizing: content-box;
}

section.additional-studies-caspian {
  padding: 10px 0 47px;
}

section.additional-studies-caspian .section-heading {
  margin: 0 0 40px;
}

h1.page-headline {
  color: #003865;
  font-family: Ubuntu;
  font-size: 38px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  margin: 0 0 20px;
}

ul.blue-arrow-list {
  padding-left: 25px;
}

h1.page-headline:last-of-type {
  margin-bottom: 24px;
}

li.blue-arrow-list__item {
  list-style-type: none;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 300;
  line-height: normal;
  position: relative;
  margin-bottom: 10px;
  color: #555;
}
li.blue-arrow-list__item::before {
  content: "";
  background: url(/content/dam/website-services/us/434-imfinzi-com/sclc-hcp/blue-list-arrow.svg)
    no-repeat;
  position: absolute;
  width: 19px;
  height: 11px;
  top: 4px;
  left: -25px;
}

.page-footnotes {
  display: flex;
  flex-direction: column;
  margin: 0;
}

.page-footnotes__item {
  display: flex;
  position: relative;
  align-items: flex-start;
  margin: 0 0 6px;
}

.page-footnotes__symbol {
  position: absolute;
  left: -1.3rem;
  width: 1.2rem;
  font-family: "Ubuntu", sans-serif;
  font-size: 64%;
  font-feature-settings: "sups" on;
  white-space: nowrap;
  line-height: normal;
  text-align: right;
  top: 0.1em;
}

.page-footnotes__text {
  margin: 0;
  color: #555555;
  /*font-family: Ubuntu, sans-serif;*/
  font-family: Ubuntu;  
  font-size: 13px;
  font-style: normal;
  font-weight: 300;
  line-height: normal;
  letter-spacing: normal;
}

.page-footnotes__item--def-block .page-footnotes__symbol {
  visibility: hidden;
}

.page-footnotes__symbol.page-footnotes__symbol--ast {
  font-size: 100%;
  top: 0;
}

h3.main-heading {
  color: #003865;
  font-family: Ubuntu;
  font-size: 24px;
  font-style: normal;
  font-weight: 500;
  line-height: normal;
  margin: 0;
  padding: 0;
}

p.main-copy {
  color: #555;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 300;
  line-height: normal;
  margin: 0;
}

.br-mobile,
.br-desktop {
  display: none;
}

section.luminance-study-design .section-heading {
  margin: 0 0 32px;
}

section.luminance-study-design h3.main-heading {
  margin: 0 0 18px;
}

.content-box-frame {
  border: 1px solid #03315d;
  width: 719px;
  position: relative;
  /*padding: 40px 15px 40px;*/
  padding: 40px 15px 25px;
  margin: 20px auto 0;
}

.content-box-frame::before {
  content: "";
  background: url(/content/dam/website-services/us/434-imfinzi-com/sclc-hcp/blue-box-arrow.svg)
    no-repeat;
  width: 69px;
  height: 41px;
  position: absolute;
  left: -25px;
  top: -21px;
  background-size: contain;
}

h3.content-box-frame__heading {
  color: #00355a;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  margin: 0;
  padding: 0 15px;
  position: absolute;
  top: -1.25rem;
  left: 4rem;
  background: #fff;
}

img.content-box-frame__image {
  margin: 0 auto;
  width: 100%;
}

li.circle-list__item {
  position: relative;
  color: #555;
  font-family: Ubuntu, sans-serif;
  font-size: 16px;
  font-weight: 300;
  line-height: normal;
  margin-bottom: 14px;
}

li.circle-list__item::before {
  content: "";
  position: absolute;
  left: -1em;
  top: 0.5em;
  width: 0.4rem;
  height: 0.4rem;
  background-color: #555;
  border-radius: 50%;
}

li.circle-list__subitem {
  position: relative;
  color: #555;
  /*font-family: Ubuntu, sans-serif;*/
  font-family: 'Ubuntu';
  font-size: 16px;
  font-weight: 300;
  line-height: normal;
  margin: 8px 0 0;
}

ul.circle-list {
  list-style: none;
  padding-left: 3rem;
  margin: 0;
}
ul.circle-list.circle-list-pc {
    padding-left: 16px;
}
ul.circle-list ul {
  padding-left: 1.5rem;
  margin-bottom: 0;
  list-style: none;
}

li.circle-list__subitem::before {
  content: "–";
  color: #555;
  line-height: normal;
  left: -1rem;
  position: absolute;
  top: 0;
}

section.luminance-study-design .page-footnotes__item p.page-footnotes__text {
  font-size: 14px;
  font-weight: 300;
  color: #4a4a4a;
}

section.luminance-study-design
  .page-footnotes__item.page-footnotes__item--def-block
  p.page-footnotes__text {
    font-size: 13px;
    line-height: 16px;
    color: #555555;
}

section.luminance-study-design .page-footnotes__item {
  margin: 0 0 4px;
}

section.luminance-study-design
  .page-footnotes__item.page-footnotes__item--def-block {
  margin-top: 4px;
}

section.luminance-safety-efficacy .section-heading {
  margin: 0 0 32px;
}

section.luminance-safety-efficacy h3.main-heading {
  margin: 0 0 18px;
}

section.luminance-safety-efficacy h4.sub-heading {
  color: #555;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  margin: 0 0 10px;
}

ul.blue-arrow-list ul {
  padding-left: 1.2rem;
  margin-bottom: 0;
  list-style: none;
}

li.blue-arrow-list__subitem {
  position: relative;
  color: #555;
  /*font-family: Ubuntu, sans-serif;*/
  font-family: 'Ubuntu';
  font-size: 16px;
  font-weight: 300;
  line-height: normal;
  margin: 8px 0 0;
}

li.blue-arrow-list__subitem::before {
  content: "–";
  color: #555;
  line-height: normal;
  left: -1rem;
  position: absolute;
  top: 0;
}

.blue-arrow-flex {
  display: flex;
  margin: 5px 0 15px;
  margin-left: -8px;
  gap: 52px;
  max-width: 720px;
}

p.blue-arrow-flex__item {
  color: #555;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 300;
  line-height: normal;
  margin: 0;
}

.blue-arrow-flex__col {
  min-width: 153px;
}

.blue-arrow-flex__col:nth-of-type(2) {
  min-width: 201px;
}

section.luminance-safety-efficacy ul.blue-arrow-list:last-of-type {
  margin: 0 0 33px;
}

.content-box-frame.content-box-frame--no-heading {
  padding: 12px 60px;
  margin-bottom: 21px;
}

section.luminance-safety-efficacy p.main-copy {
  margin: 0 0 25px;
}

section.luminance-safety-efficacy
  .page-footnotes__item.page-footnotes__item--def-block
  p.page-footnotes__text {
  font-size: 14px;
  letter-spacing: -0.28px;
}

section.luminance-safety-efficacy {
  padding: 0 0 43px;
}

h2.page-headline.last-headline-sec {
    margin: 20px 0 0;
}
.content-box-frame.content-box-frame--tall
  .content-box-frame__image.desktop-only {
  width: 608px;
  margin-left: 0;
  margin-bottom: 64px;
}

.content-box-frame.content-box-frame--tall {
  padding: 54px 22px 25px 31px;
  width: 722px;
  margin-left: 25px;
  margin-bottom: 33px;
}

p.content-copy {
  color: #003865;
  font-family: Ubuntu;
  font-size: 16px;
  font-style: normal;
  font-weight: 300;
  line-height: normal;
  margin: 0;
}

.content-label {
  border-top: 0.5px solid #003466;
  border-bottom: 0.5px solid #003466;
  padding: 12px 26px 12px 3px;
  max-width: 646px;
  margin-bottom: 51px;
}

.additional-studies-caspian .page-heading {
  padding: 60px 0 30px;
}
.additional-studies-caspian .page-heading h1 {
  max-width: 750px;
}
section.study-design h3.main-heading {
  margin: 40px 125px 20px 0;
}
section.study-design p.main-copy {
  color: #4a4a4a;
  padding-right: 20px;
  margin-bottom: 55px;
}
section.study-design .bullet-head {
  font-size: 16px;
  font-weight: 700;
  color: #003865;
  margin-top: 23px;
}
section.study-design .sub-head {
  font-size: 19px;
  font-weight: 500;
  color: #003865;
  line-height: normal;
}
section.study-design ul.circle-list {
  padding-left: 20px;
  padding-right: 20px;
}
section.study-design li.circle-list__item {
  margin-bottom: 12px;
}
section.study-design ul.circle-list ul {
  margin-top: 5px;
}
section.study-design li.circle-list__subitem {
  margin: 0;
}
section.study-design ul.hollow-circle-list {
  margin-bottom: 5px;
  padding-left: 1.2rem;
}

section.study-design ul.hollow-circle-list li {
  list-style-type: none;
  position: relative;
}

section.study-design ul.hollow-circle-list li::before {
  content: "";
  position: absolute;
  left: -1.4rem;
  top: 0.6rem;
  width: 6px;
  height: 6px;
  border: 1px solid #555;
  border-radius: 50%;
  background-color: transparent;
}

section.study-design .footnotes {
  color: #4a4a4a;
  font-size: 13px;
  margin: 35px 0 42px;
  line-height: 16px;
}
section.real-world-data h3.main-heading {
  margin: 30px 0;
}
section.real-world-data p.main-copy {
  max-width: 720px;
}
section.real-world-data .content-box-frame {
  margin: 50px auto 68px;
  padding: 10px 14px 20px 22px;
}
section.real-world-data .references p {
  margin: 0;
  padding-bottom: 48px;
  font-weight: 300;
  color: #555;
  font-size: 13px;
  line-height: 16px;
  letter-spacing: -0.13px;
}
section.real-world-data .references p .med-font {
  font-weight: 500;
}
.references p{
	font-family: "Ubuntu";
    color:#4d4d4f;
}
.references p span.med-font {
  font-weight: 700;
  font-family: "Ubuntu";      
}
h2.page-headline{
   padding: 0 ;
    margin: 0 0 20px;
   font-weight:500!important;
}

/* Desktop only */

@media (min-width: 992px) {
  section.additional-studies-caspian ul.blue-arrow-list {
    margin-bottom: 23px;
    max-width: 695px;
  }

  section.luminance-study-design p.main-copy {
    max-width: 711px;
  }

  section.luminance-study-design p.main-copy:nth-of-type(2) {
    margin-bottom: 25px;
  }

  section.luminance-study-design p.main-copy.main-copy--circle-list {
    /*margin-left: 12px;*/
    margin-bottom: 9px;
    margin-top: 19px;
  }

  section.luminance-study-design .content-box-frame {
    margin-top: 55px;
    margin-bottom: 21px;
    padding-top: 50px;
    padding-right: 13px;
    margin-left: 25px;
  }

  section.luminance-study-design .page-footnotes {
    margin-top: 26px;
  }

  section.luminance-study-design {
    padding: 0 0 43px;
  }

  section.luminance-safety-efficacy
    .content-box-frame.content-box-frame--no-heading {
    margin-right: 10px;
  }

  .br-desktop {
    display: inline-block;
  }
  .additional-studies .navbar-nav.navbar-middle > li > .dropdown-menu li a {
    padding: 11px 10px 12px !important;
    margin-right: 10px;
  }
  .additional-studies
    .navbar-nav.navbar-middle
    .dropdown-menu.multi-level
    li.caspian-efficacy {
    margin-left: 110px;
  }
  .additional-studies .page-content {
    padding: 0 18px 0 35px;
  }
  .additional-studies .section-heading h2,
  .additional-studies-caspian .page-heading h1 {
    margin-left: 110px;
  }

}

/* Mobile only*/

@media (max-width: 991px) {
  .br-mobile {
    display: inline-block;
  }
  .additional-studies-caspian .page-heading {
    padding: 20px 0 25px 22px;
  }
  .additional-studies .section-heading h2 {
    padding-left: 22px;
  }
  section.additional-studies-caspian .section-heading {
    margin: 0 0 30px;
  }
  h1.page-headline {
    font-size: 26px;
    margin: 0 0 15px;
  }
  section.additional-studies-caspian h1.page-headline:last-of-type {
    margin-bottom: 15px;
  }
  section.additional-studies-caspian {
    padding: 10px 0 17px;
  }
  .content-box-frame {
    min-width: 333px;
    width:100%;
    margin: 35px auto 22px;
    padding: 50px 37px 20px;
  }
  .content-box-frame::before {
    width: 42px;
    height: 24px;
    left: -14px;
    top: -13px;
  }
  h3.content-box-frame__heading {
    font-size: 12px;
    left: 26px;
    max-width: 240px;
    padding: 0 10px 0 10px;
    top: -8px;
  }
   img.content-box-frame__image.mobile-only.os-graph {
     width: 91%;
     margin: 30px 24px 23px;
   }
   .luminance-study-design .content-box-frame + p.main-copy {
    margin-bottom: 10px;
  }
  .luminance-study-design ul.circle-list {
    padding: 10px 0 0 15px;
  }
  section.luminance-study-design
    .page-footnotes__item.page-footnotes__item--def-block
    p.page-footnotes__text {
    font-size: 14px;
    letter-spacing: -0.14px;
    margin-bottom: 17px;
  }
  ul.blue-arrow-list {
    padding-left: 24px;
  }
  .blue-arrow-flex {
    flex-direction: column;
    gap: 0;
    margin: 8px 0 12px 0;
  }
  .content-box-frame.content-box-frame--no-heading {
    padding: 5px 3px 4px;
  }
  section.luminance-safety-efficacy p.main-copy {
    margin: 0 0 20px 0;
    padding-right: 10px;
  }
  section.luminance-safety-efficacy {
    padding: 0 0 35px;
  }
  section.study-design h3.main-heading {
    margin: 37px 55px 30px 0;
  }
  section.study-design p.main-copy {
    margin-bottom: 28px;
    padding-right: 6px;
  }
  .content-box-frame.content-box-frame--tall {
    min-width: 328px;
    width: 100%;
    margin: 0 0 30px 2px;
    padding: 35px 8px 20px 11px;
  }
  .content-label {
    margin: 17px 0 0px 0;
    padding: 17px 26px 17px 3px;
  }
  section.study-design .bullet-head {
    margin-top: 28px;
  }
  .content-box-frame.content-box-frame--tall ul.blue-arrow-list {
    padding-right: 5px;
    padding-left: 26px;
  }
  section.study-design ul.circle-list ul {
    margin-top: 8px;
    /* padding-left: 12px; */
  }
  section.study-design ul.circle-list {
    padding-right: 3px;
  }
  li.circle-list__subitem::before {
    left: -14px;
  }
  section.study-design .footnotes {
    margin: 29px 0 34px;
  }
  section.real-world-data h3.main-heading {
    margin: 23px 0;
  }
  section.real-world-data .content-box-frame {
    margin: 40px auto 30px;
    padding: 0px 1px 3px 2px;
  }
  .switch-section .switch-after {
    padding: 9px 45px 30px 16px;
    text-align: right;
  }
  .switch-section .switch-before {
    padding: 27px 0 30px 50px;
  }
  section.real-world-data .references p {
    margin: 0px 0 0;
    padding-bottom: 30px;
            padding: 0 2px 0 2px;
        letter-spacing: -0.13px;
  }
  .additional-studies .isi > h2:first-child {
    display: none;
  }
	.luminance-study-design h3.content-box-frame__heading{
    max-width: 262px;
  }
	 section.study-design ul.circle-list>li:nth-child(2){
    padding-right: 23px;
  }
	section.study-design li.circle-list__item ul>li.circle-list__subitem:nth-child(3),section.study-design li.circle-list__item ul>li.circle-list__subitem:nth-child(4){
    width: 101%;
    letter-spacing: -0.32px;
  }

}

@media screen and (min-width: 767px) and (max-width: 991px) {

    .content-box-frame.content-box-frame--tall {
        padding: 54px 22px 25px 31px;
        width: 722px;
        margin-left: 25px;
        margin-bottom: 33px;
    }


}

@media screen and (min-width:320px) and (max-width: 360px) {

            .content-box-frame {
            min-width: 100%;
        }

                .content-box-frame.content-box-frame--tall {
            min-width: 100%;
        }
 }


@media screen and (min-width: 534px) and (max-width: 991px) {
        .switch-section .switch-after {
               padding: 9px 45px 10px 16px;
            display: flex;
            justify-content: center;
                    align-items: center;
            padding-bottom: 0;
            padding-top: 0;

          }
    }


@media screen and (min-width: 425px) and (max-width: 532px) {
        .switch-section .switch-after {
    		padding: 19px 45px 20px 16px;

              }
    }