/** US-99376 Updates starts here **/

.efficacy main#maincontent {
  font-family: "Ubuntu", sans-serif;
}

.efficacy .page-heading h1 {
  letter-spacing: normal;
}

.efficacy .main-cnt.page-content h2 {
  padding-bottom: 15px;
}

.efficacy .data-compare p {
  font-size: 27px;
  line-height: normal;
}

.efficacy .data-compare .data-red-txt {
  color: #ac182e;
}

.efficacy .ef-os-data > p.hr-footnote {
  margin: 15px auto;
  font-family: "Ubuntu";
  font-size: 15px;
}

.efficacy .box-image.survival-chart > img {
  max-width: 100%;
}

.efficacy p.box-heading {
  font-weight: 300;
}

.efficacy ul.arrow-list {
  padding-left: 22px;
}

.efficacy .arrow-list li:before {
  left: -23px;
  top: 4px;
}

.efficacy .nccn-txt:after {
  content: "";
  width: 1px;
  height: 45px;
  background: #7099d3;
  position: absolute;
  right: 0;
  top: 5px;
}

.efficacy .nccn-txt {
  position: relative;
  padding: 0 16.5px 0 20px;
  margin-right: 14px;
  border-right: 0;
}

.efficacy .nccn-blck {
  padding: 9px 0;
  margin: 22px 0;
}

.efficacy .nccn-blck + .list-sec {
  margin-bottom: 22px;
}

.efficacy p.footnotes {
  letter-spacing: normal;
  margin-bottom: 11px;
}

.cas-subgroups .page-content h2 {
  margin-top: 10px;
}

h2.cas-head2 {
  padding: 0;
  margin: 0 0 10px;
}

.cas-head2 ~ p.plain-txt {
  margin: 0;
}

.cas-subgroups .ef-prcnt-comp-sec div {
  padding: 0;
  position: relative;
}

.cas-subgroups .ef-prcnt-comp-sec p {
  margin: 0 0 0 13px;
}

.cas-subgroups span.barimg-caption {
  font-size: 13px;
  font-weight: 300;
  line-height: normal;
  color: #4a4a4a;
  position: absolute;
  bottom: 25%;
  left: 31px;
}

.cas-subgroups .ef-prcnt-sec1 img {
  padding: 0;
}

.cas-subgroups .ef-prcnt-sec1 {
  margin-bottom: 18px;
}

.cas-subgroups .ef-prcnt-comp-sec + .callout {
  margin-top: 50px;
  width: 97%;
  margin-left: auto;
  margin-right: 0;
}

.cas-subgroups .ef-prcnt-comp-sec + .callout p {
  padding: 12px 14px 12px 33px;
}

.cas-subgroups .box-image.subgroup-graph img {
  max-width: 100%;
  margin: 20px 0 30px;
  position: relative;
  left: -11px;
}

.cas-subgroups .box-image.subgroup-graph + .list-sec {
  margin-bottom: 23px;
}

.cas-sd-pc .page-content h2:nth-child(1) {
  padding-top: 18px;
}

.efficacy.sclc-hcp
  .cas-sd-pc
  .box-image.study-des-img
  p.box-heading.s-line:before {
  left: -76px;
  top: -7px;
}

.box-image.study-des-img {
  padding: 0 5px !important;
  margin-top: 20px;
}

.box-image.study-des-img + .list-sec {
  margin-bottom: 28px;
}

.cas-sd-pc h2.base-head2 {
  margin-top: 15px;
  width: 98%;
}

.box-image.patient-ch-chart + .list-sec {
  margin-bottom: 29px;
}

.box-image.patient-ch-chart ~ .footnotes {
  width: 98%;
}

.efficacy .switch-section {
  height: 44px;
  align-items: center;
  position: relative;
  margin-top: 39px;
}

.efficacy .switch-section .switch-before,
.efficacy .switch-section .switch-after {
  padding-block: 0;
}

.efficacy .switch-section .switch-before {
  padding: 0 0 0 50px;
}

.efficacy .switch-section .switch-after {
  max-width: 100%;
}

.efficacy p.hr-footnote b {
  font-weight: 500;
}

.efficacy .patient-ch-chart .table-block td:first-child,
.efficacy .patient-ch-chart .table-block th:first-child {
  padding-left: 19px;
}

.efficacy .patient-ch-chart .table-block span.indent-cell {
  margin-left: 0;
}

.efficacy .patient-ch-chart .table-block .red-f-cell {
  width: 142px;
}

.efficacy .patient-ch-chart .table-block td:last-child,
.efficacy .patient-ch-chart .table-block th:last-child {
  width: 199px;
}

.efficacy .patient-ch-chart .table-block.ef-sd th {
  border-right: none;
  padding-bottom: 13px;
  padding-top: 0;
}

.efficacy .patient-ch-chart td {
  line-height: 1.45;
}

.efficacy .patient-ch-chart .table-block.ef-sd th.red-f-cell {
  background: none;
}

.efficacy .patient-ch-chart .table-block.ef-sd td,
.efficacy .patient-ch-chart .table-block.ef-sd th {
  border-color: #7070705e;
}

.efficacy .patient-ch-chart .table-block.ef-sd {
  border-bottom: 1px solid #7070705e;
}

.efficacy sup {
  font-size: 70%;
  top: -0.4em;
}

.efficacy span.ast-sup {
  top: 0;
}

.efficacy ul li {
  line-height: normal;
}
.efficacy #study-design + span {
  padding: 6px 19px;
}
@media screen and (max-width: 991px) {
  .efficacy main#maincontent {
    margin-top: 94px;
  }

  .efficacy .page-heading {
    padding: 14px 0 26px;
  }

  .efficacy .ef-os-data > p:nth-child(1) {
    letter-spacing: -0.32px;
    margin-bottom: 24px;
  }

  .efficacy .box-image.patient-ch-chart .hscroll-bar.mobile-only {
    margin: 15px -15px 10px -12px;
    max-width: 315px;
    margin-left: auto;
	margin-right: auto;
  }

  .efficacy .reference-section {
    color: #4d4d4f;
    font-family: Ubuntu;
    font-weight: 400;
    font-size: 13px;
    line-height: 16px;
    letter-spacing: 0;
    margin-left: -3px;
  }

  .efficacy .ef-os-data .data-comp-vs > img {
    width: 20px;
    height: 20px;
  }

  .efficacy .cas-subgroups .box-image.subgroup-graph img {
    margin: 10px 0 0;
  }
  .efficacy .ef-os-data .data-comp-vs {
    padding: 14px 10px 7px;
  }

  .efficacy .box-image {
    width: 97%;
    margin-left: auto;
    margin-right: 0;
  }

  .efficacy .box-image.study-des-img img.mobile-only {
    padding: 30px 0 10px !important;
  }

  .efficacy .box-image.survival-chart {
    margin: 41px 0 18px;
    width: 97%;
    margin-left: auto;
  }

  .efficacy .box-image.survival-chart p.box-heading {
    width: 90%;
  }

  .efficacy p.box-heading .box-heading_txt {
    position: relative;
    top: -2px;
  }

  .efficacy .switch-section a:before {
    top: 50%;
    transform: translateY(-50%);
  }

  .efficacy .switch-section a.switch-after:before {
    transform: translateY(-50%) rotate(180deg);
  }

  .efficacy .box-image.subgroup-chart p.box-heading {
    width: 76%;
  }

  .efficacy .box-image.subgroup-chart p.box-heading span.box-heading__lighttxt {
    min-width: 238px;
    display: inline-block;
  }

  .efficacy.sclc-hcp .subgroup-graph p.box-heading {
    width: 79%;
  }

  .efficacy .patient-ch-chart .table-block.ef-sd th:first-child:after {
    display: none;
  }

  .box-image.patient-ch-chart p.box-heading.s-line {
    padding-right: 10px;
  }
  .efficacy .section-heading span {
    padding: 6px 11px;
  }
  .efficacy ul.arrow-list {
    padding-left: 24px;
    padding-right: 10px;
  }
  .efficacy .arrow-list li:before {
    left: -23px;
    width: 18px;
    top: 4px;
    height: 11px;
  }
  .efficacy .box-image.survival-chart + .list-sec .arrow-list,
  .efficacy .box-image.survival-chart + .list-sec .arrow-list li:last-child {
    margin-bottom: 0;
  }
  .efficacy #subgroup-analysis + span {
    padding: 7px 24px 7px 21px;
  }
  .efficacy
    .cas-subgroups
    .box-image.subgroup-graph
    + .list-sec
    ~ .footnotes:last-child {
    padding-right: 20px;
  }
  .efficacy footer#footer {
    padding-right: 26px;
  }
  .efficacy .nccn-txt p:last-child {
    font-size: 13px;
  }
  .efficacy .switch-section .switch-after {
    max-width: 56%;
  }
  /* ul.nav.navbar-nav.navbar-middle li ul.dropdown-menu li a.active{
		font-weight: 700!important;
	} */

}

@media screen and (max-width: 767px) {
  .efficacy .table-block.combine-img.eff-pres-chart {
    margin-top: 12px;
  }

  .efficacy .table-block.combine-img.eff-pres-chart .left-img {
    top: -12px;
  }

  .efficacy .box-image.subgroup-chart {
    padding-left: 3px !important;
    padding-right: 7px !important;
    padding: 20px 7px 7px 3px !important;
  }

  .efficacy .box-image.subgroup-chart p.box-heading::before {
    left: -18px;
  }

  .efficacy .table-block.combine-img.eff-pres-chart + .hscroll-bar.mobile-only {
    max-width: 315px;
    margin: 13px auto 11px;
  }

  .efficacy .box-image.subgroup-chart p.footnotes {
    width: 92%;
    margin-left: 5px !important;
  }

  .efficacy .box-image.subgroup-chart p.box-heading {
    width: 77%;
    padding-left: 29px;
  }
}

@media screen and (min-width: 992px) {
  .efficacy .data-compare p {
    font-size: 26px;
  }

  .efficacy .ef-os-data .data-comp-vs > img {
    width: 28px;
    height: 28px;
  }

  .efficacy .ef-os-data > p.hr-footnote {
    margin: 10px auto;
    letter-spacing: normal;
    line-height: normal;
  }

  .efficacy .data-compare {
    justify-content: flex-start;
  }

  .efficacy .data-comp-vs {
    margin: 0 7px 0 12px;
  }

  .ef-os-data > p:nth-child(1) {
    margin-bottom: 13px;
  }

  .efficacy .box-image.survival-chart > img {
    position: relative;
    /*left: -25px;
    transform: scale(1.06);*/
    left: -6px;
    top: -15px;
  }

  .efficacy p.box-heading::before,
  .efficacy h2.box-heading::before {
    content: "";
    width: 69px;
    height: 41px;
    position: absolute;
    left: -42px;
    top: -9px;
    background: url(/content/dam/website-services/us/434-imfinzi-com/sclc-hcp/blue-box-arrow.svg)
      no-repeat;
  }

  .efficacy p.box-heading,
  .efficacy h2.box-heading {
    padding: 0 6px 0 40px;
  }

  .efficacy .box-image.survival-chart {
    padding-bottom: 0px !important;
    margin-top: 55px !important;
    margin-bottom: 34px !important;
    margin-left: 20px !important;
  }

  .efficacy .arrow-list li {
    margin-bottom: 12px;
  }

  .efficacy .nccn-blck {
    margin: 26px 0;
    padding: 11px 0;
  }

  .efficacy .nccn-txt {
    padding: 0 10px 0 35px;
  }

  .efficacy p.nccn-desc {
    margin-right: 86px;
  }

  .efficacy .nccn-blck + .list-sec {
    width: 97%;
  }

  .efficacy .section-heading.mtop_sec {
    margin-top: 41px;
  }

  .efficacy .cas-subgroups .page-content h2:first-child {
    margin-top: 23px;
    width: 95%;
  }

  .efficacy p.box-heading {
    margin-top: -35px;
  }

  .efficacy .page-content,
  .efficacy .page-heading h1,
  .sclc-hcp.efficacy .section-heading h2 {
    max-width: 750px;
  }

  .efficacy .box-image {
    max-width: 717px;
    width: 100%;
    margin-left: 25px !important;
  }

  .efficacy .list-sec {
    width: 98%;
  }

  .efficacy .cas-os p.footnotes {
    width: 98%;
  }

  .efficacy .box-image.subgroup-chart img {
    width: 653px;
    margin-left: 0;
    padding-bottom: 20px;
  }

  .efficacy .box-image.subgroup-chart {
    padding: 20px 15px 0px 10px !important;
    margin-bottom: 54px;
    margin-left: 30px !important;
  }

  .efficacy .box-image.subgroup-chart p.footnotes {
    width: 92%;
    line-height: normal;
    margin-bottom: 13px;
  }

  .efficacy h2.cas-head2 {
    margin-bottom: 22px;
  }

  .efficacy .cas-head2 ~ p.plain-txt {
    width: 94%;
  }

  .efficacy .cas-head2 + p.plain-txt {
    padding-bottom: 17px;
  }

  .efficacy .cas-subgroups .ef-prcnt-comp-sec p {
    margin-left: 22px;
  }

  .efficacy .cas-subgroups .ef-prcnt-comp-sec + .callout {
    max-width: 712px;
    width: 100%;
    margin-bottom: 43px;
    margin-left: 26px;
  }

  .efficacy .cas-subgroups .ef-prcnt-comp-sec + .callout p {
    padding: 9px 18px 12px 51px;
    letter-spacing: normal;
  }

  .efficacy .box-image.subgroup-graph p.box-heading {
    width: 93%;
  }

  .efficacy .cas-subgroups .ef-prcnt-comp-sec + .callout + h2 {
    width: 98%;
  }

  .efficacy .cas-subgroups .box-image.subgroup-graph + .list-sec {
    margin-bottom: 16px;
  }

  .efficacy .box-image.subgroup-graph {
    padding-bottom: 0 !important;
    margin-top: 39px;
  }

  .efficacy .cas-sd-pc .page-content h2:nth-child(1) {
    padding-bottom: 16px;
    width: 95%;
  }

  .efficacy.sclc-hcp
    .cas-sd-pc
    .box-image.study-des-img
    p.box-heading.s-line:before {
    left: -79px;
    top: -7px;
  }

  .efficacy .box-image.study-des-img {
    padding: 21px 116px 37px 53px !important;
    margin-top: 39px !important;
    margin-bottom: 38px !important;
  }

  .efficacy .box-image.study-des-img + .list-sec {
    margin-bottom: 20px;
  }

  .efficacy .box-image.study-des-img ~ p.footnotes {
    margin-bottom: 7px;
    width: 95.5%;
  }

  .efficacy .cas-sd-pc h2.base-head2 {
    margin-top: 32px;
  }

  .efficacy .patient-ch-chart .table-block.ef-sd {
    position: relative;
    left: -7px;
    margin: 30px auto 0px;
  }

  .efficacy .box-image.patient-ch-chart {
    padding-bottom: 39px !important;
    margin-bottom: 20px;
  }

  .efficacy .patient-ch-chart .table-block td:first-child,
  .efficacy .patient-ch-chart .table-block th:first-child {
    padding-left: 24px;
    /* background: red; */
  }

  .efficacy .box-image.patient-ch-chart + .list-sec {
    margin-bottom: 25px;
  }

  .efficacy .switch-section {
    height: 32px;
    margin-top: 50px;
    margin-bottom: 25px;
  }

  .efficacy .switch-section a:before {
    top: 0;
  }
  .efficacy.sclc-hcp .section-heading h2 {
    padding-top: 5px;
  }
  .efficacy.sclc-hcp main#maincontent {
    background-position-y: -10px;
  }

  .efficacy .page-content,
  .efficacy .page-heading h1,
  .sclc-hcp.efficacy .section-heading h2 {
    max-width: 750px;
    padding-left: 15px;
  }
  .efficacy .page-heading h1 {
    padding-left: 0;
    margin-left: -3px;
  }
  .efficacy .box-image.subgroup-graph + .list-sec {
    width: 103%;
  }
  .efficacy .cas-subgroups .box-image.subgroup-graph + .list-sec ~ .footnotes {
    padding-right: 20px;
  }
  .efficacy .box-image.patient-ch-chart + .list-sec + .footnotes {
    width: 103%;
  }
  .efficacy .nccn-txt p:last-child {
    font-size: 11px;
  }
  .efficacy .box-image.survival-chart p.box-heading {
    padding-right: 15px;
    margin-bottom: 25px;
  }
  .efficacy .cas-subgroups .ef-prcnt-comp-sec + .callout:before {
    top: 5px;
    background: url(/content/dam/website-services/us/434-imfinzi-com/sclc-hcp/blue-box-arrow.svg)
      no-repeat;
    width: 69px;
    height: 40px;
    left: -28px;
  }
  .efficacy .section-heading #overall-survival + span {
    padding: 6px 24px 6px 15px;
  }
}

.efficacy .box-image.subgroup-chart p.footnotes {
  font-size: 16px;
  margin-left: 12px;
}
.efficacy .ef-os-data > p.hr-footnote {
  color: #4a4a4a;
}
.efficacy .reference-section {
  font-family: "ubuntu";
  color: #4d4d4f;
}

/** US-99376 Updates ends here **/

@media screen and (min-width: 320px) and (max-width: 766px) {
  .efficacy .box-image.survival-chart > img {
    transform: scale(1.15);
    position: relative;
    left: -7px;
  }
}

@media screen and (min-width: 515px) and (max-width: 766px) {
  .efficacy .box-image.survival-chart p.box-heading {
    width: fit-content;
    padding-right: 1rem;
    max-width: 100% !important;
  }

  .efficacy .box-image.subgroup-chart p.box-heading { 
    width: fit-content;
    padding-right: 1rem;
    max-width: 100% !important;
  }

  .efficacy.sclc-hcp .subgroup-graph p.box-heading {

   }
}

@media screen and (min-width: 320px) and (max-width: 391px) {
  .efficacy .reference-section {
    max-width: 338px;
  }


}

@media screen and (min-width: 392px) and (max-width: 991px) {
  .efficacy .cas-subgroups .box-image.subgroup-graph img {
    max-width: 100%;
    margin: 10px auto 0;
    position: static;
  }


}

@media screen and (min-width: 767px) and (max-width: 991px) {
	.efficacy .box-image.study-des-img img {
        width: 100%;
        padding: 30px;
	}
   .efficacy .cas-subgroups .ef-prcnt-comp-sec + .callout p {
        padding: 9px 18px 12px 51px;
   }

   .efficacy .box-image.study-des-img p.box-heading.s-line {
        position: relative;
        top: 18px;
        left: 50px;
    }

}

@media screen and (min-width:320px) and (max-width: 350px) {
	.efficacy .switch-section .switch-after {
          max-width: 80%; 
    }
}


@media screen and (min-width: 600px) and (max-width: 767px ) {

    p.box-heading:before, h2.box-heading:before {
        content: "";
        background: url(/content/dam/website-services/us/434-imfinzi-com/hcc-hcp/hcc-subpages/callout-arrow.svg)
        no-repeat;
        width: 61px;
        height: 36px;
        position: absolute;
        left: -42px;
        top: -9px;
    }
    
    .efficacy.sclc-hcp
      .cas-sd-pc
      .box-image.study-des-img
      p.box-heading.s-line:before {
        left: -28px;
        top: 11px;
    }

}

    @media screen and (min-width: 320px) and (max-width: 599px ) {

    .efficacy.sclc-hcp .cas-sd-pc .box-image.study-des-img  p.box-heading.s-line:before {
      left: -26px;
      top: 16.6px;
    }
  }