main#maincontent{font-family: 'Ubuntu';}
.blank-space {
    height: 500px;
}
.f-teal {
    color: #00AB9C;
}
p.fs-16 {
    font-size: 16px;
}
.section-heading {
    margin-bottom: 25px;
}
.efficacy .section-heading {
    margin-bottom: 48px;
}
.safety .double-footnote {
    margin-left: -5px;
}
.efficacy .page-heading{
	    padding: 78px 0 55px;
}
.dosing .psa img {
    /*margin-right: 15px;*/
    max-width: 65px;
}
.page-content h2, .page-content h3 {
	font-size: 24px;
	line-height: normal;
	color: #003865;
	font-weight: 500;
	padding: 10px 0 0;
}
.efficacy #itt-os h2{
	 padding: 18px 0 0;
    margin: 18px 0px 23px 0;
}
.pos-kras-sec.pos-kras-sec1 .page-content h2, .pos-stk-sec.pos-stk-sec1 .page-content h2{ 
    margin: 0;
    padding: 26px 0 0;
}
.pos-kras-sec1 .eyebrow, .pos-stk-sec1 .page-content .eyebrow, .pos-pd-l1-sec1 .page-content .eyebrow{
    color: #003865;
    font-weight: 500;
    line-height: normal;
    margin-top: 27px;
}
.pos-kras-sec1 .eyebrow span, .pos-stk-sec.pos-stk-sec1 .eyebrow span, .pos-pd-l1-sec.pos-pd-l1-sec1 .eyebrow span{
    position: relative;
    top: -2px;
}
div#itt-pfs h2 {
    padding-bottom: 3px;
}
p.box-heading {
    font-size: 18px;
    font-weight: 500;
    color: #003865;
}
div#stk-os p.box-heading.s-line, div#pd-l1-os p.box-heading.s-line {
    font-size: 18px;
    line-height: normal;
    margin-bottom: 10px;
}
.data-compare p {
    text-align: center;
    font-size: 16px;
    line-height: 18px;
    font-weight: 400;
}
.data-teal-txt p {
    color: #007A6D;
}
.data-grey-txt p {
    color: #6F7175;
}
p.data-num {
    font-size: 61px;
    line-height: normal;
    font-weight: 700;
    margin-bottom: 0;
}
.data-compare {
    display: flex;
    justify-content: center;
    align-items: center;
    width: 100%;
}
.data-num sup {
    top: -8px;
}
.data-ver-line {
    background: #003865;
    width: 0.5px;
    height: 110px;
}
.data-comp-vs {
    padding: 0px 60px;
}
.safety .table-block .teal-cell {
    background: #F0F5FC;
}
.safety .table-block td:first-child {
    font-weight: 400;
    max-width: 200px;
}
.safety .table-block tr.span-row td:first-child {
    font-weight: 700;
}
.safety .table-block th {
    /*padding-top: 10px;
    padding-bottom: 10px;
    border-bottom: none;*/
}
.safety .data-compare {
    margin: 30px auto 20px;
    max-width: 470px;
    justify-content: space-between;
}
.page-content {
    padding-bottom: 50px;
}
div#kras-os p.footnotes{
    /*padding-bottom: 25px;*/
}
.efficacy ul.mb-33{
	margin-bottom:33px;
}
.maincontent.parsys div.rich-text:last-child .page-content, .maincontent.parsys div.rich-text:first-child .page-content {
    padding-bottom: 0;
}
.footnotes {
    font-size: 13px;
    line-height: normal;
    letter-spacing: normal;
    padding-right: 1px;
}
.moa-img-desc {
    margin-top: 19px;
}
.moa-sec-1 img {
    margin: 27px auto 0;
}
.moa-sec-2 .page-content h2{
	padding:0;
    margin:0;
}
.moa-sec-2 .page-content{
	padding:55px 0 50px;
}
.moa-sec-3 .page-content{
	padding: 0px 0 106px;
}
.moa-img-desc p {
    font-size: 20px;
    line-height: 26px;
    color: #AC182E;
    letter-spacing: 0.22px;
    font-weight: 700;
    padding-left: 0;
}
.moa-img-desc p.moa-name1 {
    color: #808184;
}
.moa-img-desc p.moa-name2 {
    color: #007A6D;
}
.moa-img-desc li {
    color: #003865;
    font-size: 16px;
    line-height: 20px;
    font-weight: 400;
    margin-bottom: 20px;
    padding-left: 0!important;
}
span.custom-bracket {
    font-size: 17px;
}

/****tab style****/
.tab-content>div {
    display: none;
}
.tab-section.ts-efficacy .tab-content>div {
    display: block;
}
.tab-heading {
    border-bottom: 1px solid #6F99D2;
    margin: 25px 0;
}
.tabs {
    display: flex;
    justify-content: center;
    list-style-type: none;
    padding: 0;
    margin: 0;
    border: 1px solid #6F99D2;
    width: fit-content;
    border-bottom: none;
    border-top-right-radius: 10px;
    border-top-left-radius: 10px;
    background: #F0F5FC;
}
.tabs li {
    position: relative;
    padding: 4px 15px 4px;
}
.tabs li:after {
    content: '';
    border-left: 1px solid #003865;
    width: 1px;
    position: absolute;
    right: 0;
    padding: 10px 0;
}
.tabs li:last-child:after {
    display: none;
}
.tab a {
    color: #003865;
    font-weight: 400;
    font-size: 12px;
    line-height: 13px;
}
.tab.active a, .tab a:hover {
    font-weight: 700;
    border-bottom: 3px solid #AC172D;
    padding-bottom: 4px;
    text-decoration: none;
}
.callout p {
    padding: 15.5px 50px;
}
.efficacy .data-num span {
    font-size: 22px;
    line-height: 26px;
}
.efficacy .data-content {
    font-size: 16px;
    line-height: normal;
}
.efficacy .data-compare {
    display: flex;
    justify-content: space-between;
    max-width: 500px;
    margin: 32px auto 25px;
    /*background: url(/content/dam/website-services/us/434-imfinzi-com/pos-hcp/desktop/pfs-divider.png)no-repeat top center;
    background-size: 1.5px 100%;*/
}
.prevalence {
    display: flex;
    align-items: center;
}
.prevalence .prevalence-contnet p {
    font-family: Ubuntu;
    font-size: 16px;
    font-style: normal;
    font-weight: 400;
    line-height: normal;
    color: #003865;
}

.prevalence .prevalence-contnet p:last-child {
    color:#4A4A4A;
    font-size: 13px;
    font-weight: 400;
    text-indent: -5px;
    margin-top: 16px;
}
.hr-footnote {
    text-align: center;
    font-size: 16px;
    line-height: 18px;
    font-weight: 400;
    color: #555454;
    margin: 10px auto;
}
.os-pd-l1-img {
   /* margin-bottom: 10px;*/
}
.orr-iit-img .hr-footnote {
    color: #4A4A4A;
    line-height: 20px;
}    
.anchoring-section .page-content {
    max-width: 680px;
    padding-bottom: 0;
}
.pos-eff-links p {
    font-size: 18px;
    line-height: 25px;
    letter-spacing: 0;
    padding: 28px 10px 28px 25px;
}
.pos-eff-links {
    width: 100%;
    display: inline-flex;
    justify-content: center;
    align-items: center;
    margin: 20px auto;
}
.pos-eff-links:before {
    top: auto;
}
.ef-anchor-sec a {
    font-size: 14px;
    line-height: 16px;
    font-weight: 700;
    color: #003865;
    background: #EBF1F8;
    padding: 13.5px 19px;
}
.ef-anchor-sec a:after {
    content: '\f078';
    font-family: fontawesome;
    padding-left: 5px;
    font-weight: 100;
    color: #AC182E;
}
.ef-anchor-sec a.anchor-up:after {
    content: '\f077';
}
.ef-anchor-sec a:hover {
    color: #ffffff;
    background: #00AB9C;
    text-decoration: none;
}
.ef-anchor-sec a:hover:after {
    color: #ffffff;
}
p.box-contains-txt {
    font-size: 16px;
    line-height: 20px;
    font-weight: 700;
    color: #4A4A4A;
}
.eyebrow {
    margin: 30px auto -20px;
    line-height: 22px;
}
.page-heading .callout {
    margin: 28px auto -2px;
}
/*.page-heading > p {
	font-size: 38px;
	line-height: 47px;
	letter-spacing: -0.76px;
}*/
.subhead-1 {
    font-size: 16px;
    line-height: 20px;
    font-weight: 400;
    color: #4A4A4A;
} 

.subhead-1-new {
    font-size: 20px;
    line-height: 24px;
    font-weight: 400;
    color: #003865;
    margin-bottom: 15px;
} 
.efficacy .subhead-1-new {
    margin-bottom: 26px;
}
.efficacy li.Median_flwup_35months{
	margin:26px 0 20px;
}

p.body-text.color-blue {
    color:#555454;
    font-size: 16px;
}

span.spacer {
    padding-bottom: 10px;
    display: block;
}

.body-text {
    font-size: 16px;
    line-height: normal;
    color: #555454;
    font-weight: 400;
    margin-bottom: 27px;
}  
.body-text b {
    font-weight: 700;
}    
.moa .subhead, .pos-pd-l1-sec .subhead, h3.sub-heading { 
    font-weight: 400;
    font-size: 20px;
    line-height: 24px;
    color: #003865;
    padding-bottom: 10px;        
} 
.moa .subhead {
	font-weight: 500;
    padding:0;
    margin:0;
}
.pos-ar .data-compare .data-grey-txt .data-content {
    /*line-height: 24px;*/
}
.arrow-list li {
    line-height: 20px;
    margin-bottom: 15px;
    color: #555;
    /* padding-left: 8px; */
    padding-right: 1px;
}
.arrow-list li.Median_OS_5_year{
	    margin-bottom: 0;
}
.pos-im-ar .callout p {
    padding: 15.5px 41px 15.5px 50px;
}
.table-block th {
    /*border-right: none;*/
    background: #ffffff;      
}
.table-block th, .table-block td {
    font-size: 14px;
    line-height: 16px;
    padding: 7px 10px;
}
.switch-section a {
    font-size: 16px;
    line-height: 20px;
    color: #003865;
}
.section-divider {
    border-top: 1px solid #003865;
    width: 100%;
    height: 1px;
    position: absolute;
    left: 0;
}
.switch-section {
    margin: 0px auto 43px;
}
.moa .switch-section {
    margin: 0px auto 57px;
}
.safety .sf-ar-2.table-block th {
    padding: 7px 10px;
}
.safety .sf-ar-2.table-block th:first-child {
    border-bottom: 0;
}
.pos-im-ar .table-block.ds-treat {
    margin: 40px auto 10px;
}
.ds-treat td, .ds-treat th {
    white-space: normal;
    text-align: left;
    padding: 7px 10px;
    line-height: 18px;
}
.ds-treat tr.blue-row th, .ds-treat tr.blue-row td {
    background: #E8F1F7;
}
.ds-treat .span-row, .ds-treat .span-row td {
    background: #CCDAF1;
}
.ds-treat .span-row td {
    color: #003262;
}
td.no-cell {
    display: none;
}
td.cell-bb-0 {
    border-bottom: 0;
}   
.psa {
    display: inline-flex;
    align-items: center;
    width: 100%;
}

.psa.m-psa {
    align-items: flex-start;
} 
.pos-psa .page-content p {
    font-size: 16px;
    line-height: 24px;
    font-weight: 700;
    color: #555555;
    margin: 15px 0;
} 
.pos-psa .page-content p.footnotes {
    font-size: 13px;
    line-height: 18px;
    letter-spacing: 0.07px;
    font-weight: 300;        
}
.hr-scroll-txt p {
    font-weight: 700;
    font-size: 14px;
    line-height: 16px;
    letter-spacing: 0.03px;
    position: relative;
    text-align: center;
}
.hr-scroll-txt p:after {
    padding-left: 3px;
    padding-top: 1px;
    content: '\f054';
    font-family: fontawesome;
    font-weight: 100;
    font-size: 13px;
    position: absolute;
    -webkit-text-stroke: 1px #fff;
    display:none;
}
.ds-treat.table-block {
    max-width: 635px;
}
.ds-treat.table-block th, .ds-treat.table-block td:last-child{
    text-align: center;
}
.pos-recom-dos img {
    margin: 0 auto 20px;
}
.moa-sec-1 h2 {
    margin: 0;
    padding:0 0 14px;
}
.nccn-sec {
    color: #003865;
    display: flex;
    justify-content: space-between;
    align-items: center;
    width: 100%;
    padding: 10px;
    border-top: 2.12px solid #003865;
    border-bottom: 2.12px  solid #003865;
    margin: 20px auto 37px;
}

.nccn-heading p {
    font-weight: 700;
    font-size: 48px;
    line-height: 21px;
    margin-bottom: 0;
    padding-top: 10px;
}
.nccn-heading p span {
    font-size: 21px;
}
.nccn-content p {
    font-size: 14px;
    line-height: normal;
    font-weight: 400;
    margin-bottom: 0;
    color: #003865;
}
.per-block {
    display: flex;
    align-items: center;
    border-radius: 23px;
    border: 1px solid #AD1F2F;
    background: #FFF;
    padding: 25px 23px;
    position:relative;
    margin-bottom: 27px;
}
.per-block h5 {
    width: 64px;
    height: 64px;
    background: #007A6D;
    color: #fff;
    border-radius: 50px;
    font-size: 31.5px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    letter-spacing: -1.575px;
    position: absolute;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 2px;
}
.per-block h5 span {
    font-size: 18px;
}
.pos-kras-sec.pos-kras-sec1 .per-block h2, .pos-stk-sec.pos-stk-sec1 .per-block h2, .pos-pd-l1-sec.pos-pd-l1-sec1 .per-block h2 {
    font-size: 20px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    color:#007A6D;
    padding: 0 50px 0 81px;
    margin:0;
}


/*****************************Disease State *************************************/
.about-btcs-sec h2.mt-12{
	font-size: 38px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    margin: 0 0 24px;
    padding: 0;
}
.about-btcs-sec p.about-mnsclc{
	font-size: 20px;
    font-style: normal;
    font-weight: 500;
    line-height: normal;
    color: #003865;
}
.about-btcs-sec p.box-heading {
    max-width: 529px;
    margin: -30px 0 42px 37px;
    font-size: 18px;
    line-height: normal;
    letter-spacing: normal;
}
.about-btcs-sec .box-image.box-2 p.box-heading{
    max-width: 578px;
    margin-left: 20px;
}
.about-btcs-sec .box-image.box-1 {
	padding: 20px 20px 38px;
    border: 1px solid #003865;
}

.about-btcs-sec .box-image.box-1 img {
    margin-right: 10px;
}

.about-btcs-sec .box-image.box-1 img, .about-btcs-sec .box-image.box-2 img{
    margin-left: 10px;
}
.about-btcs-sec .box-content1{
	/*float: right;
    margin-right: 72px;*/
    display: flex;
    margin-right: 72px;
    font-size: 20px;
    font-style: normal;
    font-weight: 400;
    line-height: normal;
    color: #003865;
    align-items: center;
}
.about-btcs-sec .box-content-txt1{
    display: flex;
    font-size: 20px;
    gap: 40px;
    position: relative;
    top: 22px;
}
.about-btcs-sec .box-content1 li{
	list-style: none;
    color: #003865;
	margin-bottom: 7px;
}
.about-btcs-sec .box-content1 li.dash-style{
	    padding-left: 11px;
}
.about-btcs-sec .box-content1 li.mb-15{
	margin-bottom: 15px;
}

.about-btcs-sec .box-image.box-2 p.box-heading sup {
    font-family: sans-serif;
}
.txt-indent{
	    text-indent: -7px;
}

.efficacy .box-image > p.eyebrow {
    margin-top: 0;
}

.efficacy  .box-image.os-kras-img {
    margin: 40px auto 0;
}

.efficacy .box-image.box-image--circles {
    margin-top: 20px;
}

 .efficacy  .box-image.os-skt-img {
    margin-top: 40px;
}

 .efficacy  .box-image.os-pd-l1-img {
    margin-top: 40px;
}
 .about-btcs-sec p.txt-indent sup {
    font-family: sans-serif;
}

.about-btcs-sec p.txt-indent{
	font-size: 13px;
    font-style: normal;
    font-weight: 400;
    line-height: normal;
}
.about-btcs-sec .box2-content1{
	display: flex;
    margin-right: 189px;
    font-size: 20px;
    font-style: normal;
    font-weight: 400;
    line-height: normal;
    color: #003865;
    align-items: center;
}
.about-btcs-sec .box2-content-txt1>p{
	margin: 0 0 15px;
}
.about-btcs-sec .box-image.box-2{
	    padding: 20px 20px 46px;
}
.about-btcs-sec .callout-disease{
	border: 1px solid #AD1F2F;
    max-width: 850px;
    margin: 24px auto 38px;
    border-radius: 23px;
    position: relative;
}

.about-btcs-sec .box-image.box-2 .box2-content-txt1 sup {
    font-family: sans-serif;
} 

.about-btcs-sec .callout-disease p{
    font-family: Ubuntu;
    font-size: 20px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    color: #007A6D;
    padding: 25px 49px 22px 24px;
    text-box: cap alphabetic;
    margin: 0;
}
.about-btcs-sec .box-image.box-3{
		 padding: 20px 20px 44px 42px;

}
.about-btcs-sec .box-image.box-3 .box-heading{
    max-width: 731px;
    padding: 0 2px;
    margin: -30px 0 0 0px;
}
.about-btcs-sec .box-image.box-3 .box3-content1{
	display: flex;
    align-items: center;
}
.about-btcs-sec .box-image.box-3 .box3-content1 img{
    margin: 0;
    margin-right: 20px;
}
.about-btcs-sec .box-image.box-3 .box3-content-txt1 p{
	font-size: 16px;
    position: relative;
    padding-left: 26px;
    color: #555;
}
.about-btcs-sec p.arrow-list:before{
	content: "";
    background: url(/content/dam/website-services/us/434-imfinzi-com/pos-hcp/desktop/list-arrow.svg) no-repeat;
    position: absolute;
    width: 26px;
    height: 13px;
    top: 5px;
    left: -32px;
    margin-left: 26px;
}
.about-btcs-sec p.footnotes.ftnt-dease.mt-14{
	margin-top: 14px;
}
.about-btcs-sec .page-content{
	padding-bottom: 13px;
}
/*****************************Disease State end*************************************/


@media only screen and (max-width: 991px) {
    .moa-sec-1 img{width:100%;}
    li.pos-moa a:before {
        display: none;
    } 
    .moa .page-content h3 {
    	margin-top: 0px;
	}
    p.box-heading br.m-none{
        display:none;
    }
    .safety .pos-lab-ab .box-heading{padding-right: 35px;}
    .safety p.box-heading.s-line{padding-right: 15px;}
    .txt-nowrap{white-space: nowrap;}
    .movie.page-content{padding-bottom: 10px;}
    .moa.pos-hcp div#myEmbedTarget_1_g9hqx9s9,
    .moa.pos-hcp div#myEmbedTarget_1_0yj2kbow {
        width: 100%!important;
        height: 56vw!important;
    }
	.page-content.moa-sec-0 .page-heading{
		padding: 25px 15px 24px;
     }
	.page-content.moa-sec-0{
		border-bottom: 0.25px solid #555;
    	margin: 0;
    }
	.moa-sec-1 h2 {
		padding: 15px 21px 38px 0;
    }
	.moa-sec-1 .page-content{
		padding-bottom: 40px;
    }
	.moa-sec-2 .page-content {
		padding: 0px 0 23px;
    }
    .moa-sec-3 .page-content {
        padding: 11px 0 34px;
    } 
	/*****************************Disease State start*************************************/
	.disease-state .page-heading {
     	padding: 30px 15px 24px;
    }
    .about-btcs-sec h2.mt-12 {
        font-size: 26px;
        margin: 0 0 20px;
    }
	.about-btcs-sec .box-image.box-1 p.box-heading {
		/*max-width: 301px;*/
    	width: 83%;
        background: transparent;
    	margin: -30px 0 26px 10px;
    }
	.about-btcs-sec .box-image.box-1 b.custom-border{
		background: #fff;
    }
    .about-btcs-sec .box-content1 {
		/*float: initial;*/
    	justify-content: center;
        margin-right: 0;
    }
    .about-btcs-sec .box-content-txt1 {
        flex-direction: column;
        align-items: center;
        gap: 0;
    top: 0;
    }

    .about-btcs-sec .box-content-txt1 ul:first-of-type {
        margin-bottom: 5px;
    }
    .about-btcs-sec .box-content-txt1 ul{
		padding-left: 0;
    	text-align: center;
    }
	.about-btcs-sec .box-content1 li:nth-child(1){
		margin-bottom: 4px;
    }
	.about-btcs-sec .box-content1 li:nth-child(2), .about-btcs-sec .box-content1 li:nth-child(3){
		margin-bottom: 2px;
    }
	.about-btcs-sec .box-content1 li.mb-15 {
		margin-bottom: 10px;
    }
	.about-btcs-sec .box-image.box-1{
		padding: 20px 10px 30px;
    }
	.about-btcs-sec .box-image.box-2 p.box-heading {
		max-width: 280px;
		margin: -30px 0 37px 10px;
    }
	.about-btcs-sec .box2-content1 {
		margin-right:0;
    }
	.about-btcs-sec .box2-content1 .box2-content-txt1 p{
        text-align: center;
        margin-bottom: 5px;
    }
	.about-btcs-sec .callout-disease{
		margin: 29px auto 41px;
    }
	.about-btcs-sec .callout-disease p {
    	padding: 10px 10px 10px 15px;
     }
	.about-btcs-sec .box-image.box-3 {
		padding: 20px 11px 14px 9px;
    }
	.about-btcs-sec .box-image.box-3 .box-heading {
		font-size: 16px;
    	margin: -30px 0 0 16px;
        max-width: 290px;            
    }
	.about-btcs-sec .box-image.box-3 .box3-content1 {
		flex-direction: column;
     }
	.about-btcs-sec .box-image.box-3 .box3-content1 img {
        margin: 30px 0px;
    	width: 227.699px;
		height: 267.523px;
    }
	.disease-state .switch-section{
		margin:0 auto;
        width: 90%;
    	margin-top: 14px;
    	padding-bottom: 10px;
    }
	 .disease-state .switch-section .switch-before {
        padding: 30px 0 30px 50px;
    }
	.disease-state .switch-section .switch-after {
        padding: 30px 50px 30px 0px;
    }

    .disease-state .about-btcs-sec .box-image.box-1 p.box-heading {
        font-size: 16px;
        line-height: normal;
        font-weight: 700;
    }

    .disease-state .about-btcs-sec  .box-image.box-2 p.box-heading {
        font-size: 16px;
        line-height: normal;
        font-weight: 700;
    	background: transparent;
    }
	.disease-state .about-btcs-sec  .box-image.box-2 p.box-heading b{
    	background: #fff;
    }
    .disease-state .about-btcs-sec .box-content-txt1 li.dash-style {
        font-size: 18px;
    	text-align: left;
    }
	.efficacy .page-heading .sub-head p{
		font-size:20px;
        padding-right: 13px;
    }
	.efficacy .page-heading {
        padding: 30px 0 20px;
    }
	.efficacy p.box-heading {
        font-size: 16px!important;
        margin-left: 18px;            
    }
	.efficacy .box-image {
		padding: 20px 9px 30px;
    }

	.efficacy  .box-image.os-skt-img  img {
        max-width: 100%;
    }
	.efficacy .section-heading {
        margin-bottom: 21px;
    }
	.efficacy #itt-os h2 {
		margin: 6px 0px 10px 0;
    }
	.efficacy #kras-os .prevalence{
		flex-direction: column;	
    }
	.efficacy #kras-os .prevalence img{
		width: 209.103px;
		height: 245.72px;
        margin: 10px 0 20px;
    }
	.efficacy #stk-os .prevalence{
		flex-direction: column;
    }
    .efficacy #stk-os .prevalence img{
		width: 209.103px;
		height: 245.72px;
        margin: 10px 0 20px;
    }
	.efficacy #pd-l1-os .prevalence{
		flex-direction: column;
    }
    .efficacy #pd-l1-os .prevalence img{
		width: 209.103px;
		height: 245.72px;
        margin: 10px 0 20px;
    }
    .efficacy #kras-os p.eyebrow{
		margin-top: 10px;
     }
     .efficacy #kras-os .box-image.os-kras-img .box-heading.s-line{
		margin-left: 16px;
        padding: 0 0px 0 0px;
        padding-left: 5px;
        width: 92%;
     }
	  .efficacy #kras-os .box-image.os-kras-img img{
		max-width: 331px;
        padding-top:20px;
     }
	.efficacy #kras-os .per-block, .efficacy #stk-os .per-block, .efficacy #pd-l1-os .per-block{
        padding: 15px 15px 17px 23px;
        margin-bottom: 20px;
     }
	.efficacy #kras-os .per-block h2, .efficacy #stk-os .per-block h2, .efficacy .pos-pd-l1-sec.pos-pd-l1-sec1 .per-block h2{
		    padding: 0 0px 0 80px;
    		text-box: cap alphabetic;
     }
	.efficacy #stk-os span.spacer{
		padding-bottom: 0;
    }
	.efficacy .page-content {
        padding-bottom: 42px;
    }
	.efficacy div#stk-os p.box-heading.s-line, div#pd-l1-os p.box-heading.s-line {
        margin-right: 23px;
        margin-left: 11px;
        padding-right: 0;
        padding-left: 3px;
    }

    div#pd-l1-os p.box-heading.s-line {
        margin-left: 15px;
        width: 92%;
        padding-left: 5px;
    }
	.efficacy div#stk-os p.box-heading.s-line {
        max-width: 270px;
        margin-left: 15px;
        padding-left: 5px;
    }
	.efficacy #pd-l1-os .box-image.os-pd-l1-img img{
		max-width: 336px;
    }
	.efficacy .switch-section {
		width: 90%;
        margin: 0px auto 0px;
    }

    .efficacy .pos-itt-sec p.section-head,
    .efficacy .pos-pd-l1-sec.pos-pd-l1-sec1 p.section-head{
        margin-top: -1px;
    }

	 .isi>h2:first-child {
        display: none;
    }
	.moa .switch-section {
        margin: 0px 22px 0px;
    }
	.moa .switch-section .switch-before {
        padding: 30px 0 30px 50px;
    }
 .moa .switch-section .switch-after{
    	text-align:left !important;
     }

    .moa .switch-section a:before {
        top: auto;
    }

    .metastatic-safety-new .pos-lab-ab p.section-head {
        margin-top: -2px;
    }


}
@media screen and (min-width: 768px){
	.maincontent.parsys .rich-text, .efficacy .maincontent.parsys div.rich-text:nth-last-child(2) {
	    /*border-bottom: 25px solid #ecf1f6;*/
        position: relative;            
	}
	.maincontent.parsys div.rich-text:first-child, .moa .maincontent.parsys div, .maincontent.parsys div.rich-text:nth-last-child(2) {
	    border-bottom: none;
	}
    .pos-recom-dos .callout p {
    	padding-right: 44px;
	}
	.pos-recom-dos .page-content {
    	padding-bottom: 50px;
	}
	.pos-psa .psa {
    	margin-bottom: 30px;
    	/*position:relative;
    	left:-5px;*/
	}
	.safety .table-block td:first-child {
    	max-width: 260px;
	}
    .pos-psa .psa .list-sec {
    	margin-top: 4px;
	}
	.pos-psa .psa.s-psa .list-sec {
    	margin-top: 10px;
	}
	.pos-psa .psa .list-sec {
    	margin-left: 30px;
	} 
	.nccn-heading p{
        padding-right: 15px;
        border-right: 2.20px solid #003865;
    }
    .nccn-content {
        padding-left: 12.5px;
    }
    .nccn-content p b {
        line-height: normal;
    }
    .icon-mar-lft{
        margin-left: 3px;
    }
}
@media screen and (min-width: 992px){
    .moa .page-content h3 {
    	margin-top: -10px;
	}
    .efficacy .os-kras-img img.desktop-only{padding: 12px 0 0;}
    .efficacy .os-skt-img img.desktop-only{padding: 10px 0 5px;}
    .efficacy .os-pd-l1-img img.desktop-only{padding: 12px 0 0;}
    .box-image.os-kras-img img{
        margin-top: 15px;
    }

    .disease-state .about-btcs-sec h2.mt-12 {
        margin-top: 0;
    }
    .disease-state .about-btcs-sec .box-image.box-1 {
        margin-top: 35px;
    }

    .disease-state .reference-section {
        max-width: 700px;
        padding-right: 12px;

    }
	.disease-state  .box3-content-txt1 {
        margin-top: 60px;
        line-height: 21px;
    }
	.disease-state .about-btcs-sec .box-image.box-1 .box-heading {
        margin-left: 20px;
    	margin-bottom: 35px;
    }
	.efficacy .prevalence-contnet{
		margin-top: 30px;
	}

	.efficacy .box-image.pfs-iit-img ul.arrow-list li {
        margin-bottom: 0;
    }
	.efficacy #kras-os h2.mtop_40 {
        padding-top: 0;
    }
    .efficacy div#kras-os ul.arrow-list li:last-of-type {
       padding-bottom: 0;
    }
	.efficacy .box-image.os-iit-img p.box-heading {
        font-size: 16px;
    }

    .efficacy .list-sec.list-sec--1 {
        margin-top: 20px;
    }
    .efficacy .prevalence .prevalence-contnet p:first-of-type {
        margin-bottom: 24px;
    }


}
@media screen and (max-width: 767px) { 
	p.box-heading.s-line:before, h2.box-heading.s-line:before {
        left: -35px;
        top: -5px;
    }
    .psa {
        flex-direction: column;
        align-items: flex-start;
    }
    .psa img {
        margin: 0 auto;
    }  
    .ds-treat.table-block th, .ds-treat.table-block td {
    	white-space: nowrap;
	}  
    .data-num sup {
    	top: -10px;
	}
   .ds-treat.table-block td:first-child {
    	max-width: 150px;
    	white-space: normal;
	} 
    span.custom-bracket {
        font-size: 14px;
    }
    .eyebrow {
    	margin: 0px auto -20px;
        line-height: normal;
	}        
    .tab-heading {
    	margin: 20px 0 18px;
	}        
    .data-compare p {
    	font-size: 12px;
    	line-height: 13px;
	}
    .efficacy .data-compare {
    	max-width: 283px;
    	flex-direction: column;
    }
	 .efficacy .data-ver-line {
        width: 110px;
        height: 0.5px;
    	margin: 11px 0 6px
    }
	div#itt-pfs h2 {
        margin-top: 40px;
    }
	p.data-num {
    	font-size: 61px;
    	line-height: normal;
    	margin-bottom: 0;
    	display: flex;
        align-items: flex-end;
    }  
	.hr-footnote {
    	font-size: 12px;
    	line-height: 13px;
    	margin: 15px auto 10px;
	}
	.efficacy .hr-footnote {
    	font-size: 16px;
    	line-height: normal;
    	margin: 15px auto 32px;
	}
    .efficacy .data-num span {
    	font-size: 34px;
    	line-height: normal;
    	letter-spacing: 0;
    	display: block;
    	margin: 0 0 5px 9px;
	}
    .data-comp-vs {
    	padding: 0px 10px;
    } 
	.safety .data-comp-vs {
    	padding: 0px 4px;
    }
	.efficacy .data-content {
    	font-size: 16px;
        line-height: normal;
	}
    .box-image .data-comp-vs img {
    	max-width: 28px;
    	height: auto;
	} 
	.safety .data-compare {
    	margin: 10px auto 0;
	}
    .callout.pos-eff-links {
        flex-direction: column;
        padding-bottom: 30px;
    	margin: 20px 5px 30px;
    }
    .ef-anchor-sec a {
        padding: 13.5px 12px;
    }
    .pos-eff-links p {
        padding: 15px 0px 20px 20px;
        font-size: 16px;
    	line-height: 20px;
    }
    .tab a {
        font-size: 11px;
        line-height: 12px;
	}
    .tabs li {
	    padding: 11.5px 11px 11.5px;
	}
	.tab.active a, .tab a:hover {
    	padding-bottom: 12px;
	}
    .box-image img {
    	max-width: 304px;
	}
	.box-image.os-iit-img img.mobile-only {
        max-width: 323px;
        width: 323px;
    }
	.pos-recom-dos .callout p {
    	padding: 14.5px 40px;
	}
    .page-heading .callout {
    	margin: 10px 0 10px 22px;
	}
	.page-heading .callout p {
    	padding: 15.5px 34px;
    	font-size: 18px;
	}
	.body-text {
    	font-size: 16px;
    	\: normal;
    	margin-bottom: 18px;
 }
	.pos-eff-links:before {
    	top: 13px;
	}
    .page-heading > p {
    	font-size: 26px;
    	line-height: 29px;
    	letter-spacing: -0.52px;
	}
    .safety .table-block th:first-child:after {
    	display: none;
	}
	.os-iit-subgroup-img .table-block th:last-child img {
    	max-width: 596px;
    	margin-top: 0;
 }
	.os-pd-l1-img .table-block th:last-child img {
    	max-width: 509px;
	}
	.os-iit-subgroup-img .table-block th, .os-pd-l1-img .table-block th {
    	padding: 0;
    	border: none;
	}
    .box-image.os-iit-subgroup-img p.box-heading {
        font-size: 16px;
        line-height: normal;
        padding: 0 4px;
        margin-left: 15px;
        max-width: 272px;
        padding-left: 5px;
    }
    .box-image.pfs-iit-img p.box-heading.s-line {
        font-size: 16px;
        line-height: normal;
        margin-left: 20px;
        max-width: 215px;
   		padding-left: 5px;
    }
    .table-block td {
    	font-size: 10px;
    	line-height: 11px;
	}
    .table-block.sf-ar-1 th {
    	font-size: 11px;
    	line-height: 13px;
	}
	.sf-ar-1 {
    	margin: 20px -15px 5px;
	}
	.sf-lab th sup {
    	position: inherit;
    	vertical-align: revert;
	}
	.pos-stk-sec .page-content {
    	/*padding-bottom: 0;*/
	}
	.table-block td sup {
    	position: inherit;
    	vertical-align: top;
	}
	.pos-recom-dos .sub-heading {
    	margin-top: -10px;
	}
	.dosing .switch-section .switch-after {
    	padding: 20px 50px 30px 0;
    	text-align: right;
	}
	p.box-heading.new{
    	padding-left:14px;
	}
	div#myEmbedTarget_1_omal6p95{
    	max-width: 100%;
    	width: 336px !important;
    	max-height: 183px !important;
    	margin: 0 auto 50px;
	}
	.nccn-sec {
        /* flex-direction: column; */
        margin-bottom: 21px;
    }   
    .nccn-heading p {
        text-align: center;
        padding-bottom: 12px;
        /* border-bottom: 1.5px solid #003865; */
        padding-right: 9px;
    }
    .nccn-content p {
        padding-top: 0;
        margin-right: -23px;
        border-left: 1.5px solid #003865;
        padding-left: 9px;
    }

    .efficacy .list-sec.list-sec--1 {
        margin-top: 20px;
    }
}
@media screen and (max-width: 364px) {  
    .tab a {
    	font-size: 9px;
    }   
}
@media screen and (max-width: 370px) {  
	.moa-sec-1 img {
    	max-width: 290px;
	}
    .box-image img {
    	max-width: 230px;
	}  
	div.rich-text:last-child .anchoring-section .page-content {
    	margin: 20px 0px 30px;
	}
}
@media screen and (max-width: 350px) {  
    .pos-eff-links p {
    	padding: 15px 0px 20px 13px;
    	font-size: 14px;
    }
    p.data-num {
    	font-size: 45px;
    }
    .pos-recom-dos img {
    	max-width: 300px;
	} 
   
}
@media screen and (max-width: 390px) {  
	.spl-lne-br-fr-390{
		display:block;
     }
}
@media screen and (min-width: 391px) {  
	br.spl-lne-br-fr-390{
		display:contents!important;
     }
}

.disease-state .about-btcs-sec h2.mt-12 {
    font-size: 24px;
}

.disease-state span.ast-pos {
    position: relative;
    top: -3px;
}